Eric Stanton Diffenderfer, PhD

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Description of Research Expertise

FLASH radiotherapy.
Proton SARRP development.
Proton and neutron microdosimetry.
Machine learning applications in Radiation Oncology.

Description of Clinical Expertise

Proton and X-ray therapy physics and dosimetry.

Selected Publications

• Eric Diffenderfer : Time Resolved Microdosimetric Analysis for Extrapolating Low Dose Rate Data to FLASH Proton Therapy Conditions PTD Workshop, Prague, Czech Republic June 2026
• Diffenderfer, E., Nakamura, S., Masuda, A., Tanaka, H. : Neutron Detectors and Measuring Methods Radiation Detectors and Methods in Medicine January 2026 Notes: https://doi.org/10.1007/978-3-032-10159-4_19
• Xiaokun Teng, Andrew Friberg, Daniel A Alexander, Kan Ota, Matthew Nichols, Paul Boisseau, Francois Vander Stappen, Yin Gao, Jufri Setianegara, Wenbo Gu, Eric Diffenderfer, BoonKeng Kevin Teo, Lingshu Yin, Wei Zou : Conventional and ultra-high dose rate proton beam energy and output characterization using a high-resolution multi-layer Faraday cup Physics in Medicine and Biology 2026 Notes: DOI: 10.1088/1361-6560/ae94d9
• Zou W, Dong L, Pin A, Nilsson R, Kim M, Apinorasethkul O, Pakela J, Friberg A, Koger B, Labarbe R, Fuentes CL, Cengel K, Traneus E, Girdhani S, Koumenis C, Vander Stappen F, Diffenderfer E, Bradley J, Teo BK, Lin A. : Deliverable proton conformal FLASH radiotherapy treatment planning for head and neck re-irradiation patients Radiotherapy and Oncology 216: 111349 December 2025 Notes: doi: 10.1016/j.radonc.2025.111349
• Arash Darafsheh, Yao Hao, Anissa Bey, Michele M Kim, Eric S Diffenderfer, Lingshu Yin, Chin-Cheng Chen, Zhiyan Xiao, S Murty Goddu, Gabriele Zorloni : First multi-institutional systematic comparison of the neutron ambient dose equivalent produced by proton therapy systems Physics in Medicine and Biology 70 November 2025 Notes: https://doi.org/10.1088/1361-6560/ae1ee5
• Lucian Hotoiu, Francois Vander Stappen, Arnaud Pin, Rasmus Nilsson, Justin Ivoc, Michele Kim, Eric Diffenderfer, Boon-Keng Kevin Teo, Rudi Labarbe : Experimental validation of coarse ridge filters for FLASH proton therapy Medical Physics 52(9) September 2025 Notes: https://doi.org/10.1002/mp.18044Digital Object Identifier (DOI)
• Friberg AM, Tan HS, Diffenderfer ES, Verginadis I, Kim MM, Cengel K, Wiersma R, Dong L, Koumenis C, Teo BK, Zou W. : Physicochemical indication of the FLASH effect from shoot-through proton pencil beam scanning parameters delivered under ultra-high dose rates Physics in Medicine and Biology 70(17):175002 August 2025 Notes: doi: 10.1088/1361-6560/adf58e
• Arpit M. Chhabra MD, Richard A. Amos MSc, FIPEM, Charles B. Simone II, MD, Adeel Kaiser MD, Luis A. Perles PhD, Huan Giap MD, PhD, Christopher L. Hallemeier MD, Jedediah E. Johnson PhD, Haibo Lin PhD, Andrew J. Wroe PhD, Eric S. Diffenderfer PhD, John A. Wolfgang PhD, Hideyuki Sakurai MD, Hsiao-Ming Lu PhD, Theodore S. Hong MD, Eugene J. Koay MD, PhD, Kazuki Terashima PhD, Pavel Vitek PhD, William G. Rule MD, Smith Jim Apisarnthanarax MD, Shahed N. Badiyan MD, Jason K. Molitoris MD, PhD, Michael Chuong MD, Romaine C. Nichols Jr. MD : Proton Beam Therapy for Pancreatic Tumors: A Consensus Statement from the Particle Therapy Cooperative Group Gastrointestinal Subcommittee International Journal of Radiation Oncology • Biology • Physics 122(1) May 2025 Notes: doi: 10.1016/j.ijrobp.2024.12.020
• Seyyedeh Azar Oliaei Motlagh, François Vander Stappen, Michele M Kim, Rudi Labarbe, Lucian Hotoiu, Arnaud Pin, Rasmus Nilsson, Erik Traneus, Keith A Cengel, Wei Zou, Boon-Keng Kevin Teo, Lei Dong, Eric S Diffenderfer : Verification of dose and dose rate for quality assurance of spread-out-Bragg-peak proton FLASH radiotherapy using machine log files Medical Physics April 2025 Notes: DOI: 10.1002/mp.17792
• Haiwei Ni, Zachary J Reitman, Wei Zou, Md Naushad Akhtar, Ritama Paul, Menggui Huang, Duo Zhang, Hao Zheng, Ruitao Zhang, Ruiying Ma, Gina Ngo, Lin Zhang, Eric S Diffenderfer, S Azar Oliaei Motlagh, Michele M Kim, Andy J Minn, Jay F Dorsey, Jessica B Foster, James Metz, Constantinos Koumenis, David G Kirsch, Yanqing Gong, Yi Fan : FLASH radiation reprograms lipid metabolism and macrophage immunity and sensitizes medulloblastoma to CAR-T cell therapy Nature Cancer February 2025 Notes: DOI: 10.1038/s43018-025-00905-6