b9
13
d
d
69
f
15
1
1
1
24
19
38
11
17
1
15
15
11
3a
9
13
d
9
9
19
9
d
11
9
9
11
9
13
19
19
49
19
19
18
1 18
1 1 1 2b
11
15
11
15
25
11
11
11
18
34 Eric Stanton Diffenderfer, PhD
1 19 19 31 19 65 19 19 49 31 31 19 19 19 19 19 45
3b
19
19
19
1
1
1
1
2d
9b
2f
1
1
5
2f
75
7
Associate Professor of Radiation Oncology at the Hospital of the University of Pennsylvania
1874 Department: Radiation Oncology
11 131 18
e
1
5
25
5
e
Contact Information
c
3a
3400 Civic Center Blvd
65
TRC 2 West
Philadelphia, PA 19104
ba
Email: Eric.Diffenderfer@pennmedicine.upenn.edu
1e
9
e
Publications
71 b
17
9
12
Links
d b
1b
b
Education
d-
1d
-
30
B.S. (Physics)
57
The Evergreen State College, 2001
1d
-
30
M.S. (Physics)
54
Florida State University, 2004
1d
-
39
Ph.D. (Nuclear Physics)
54
Florida State University, 2007
1a
1 1 1 2b
Description of Research Expertise
1eFLASH radiotherapy.
21
Proton SARRP development.
2a
Proton and neutron microdosimetry.
39
Machine learning applications in Radiation Oncology.
Description of Clinical Expertise
37Proton and X-ray therapy physics and dosimetry.
1 1 1 1fSelected Publications
5-
5
- 75 Diffenderfer, E., Nakamura, S., Masuda, A., Tanaka, H. : Neutron Detectors and Measuring Methods 81 Radiation Detectors and Methods in Medicine January 2026 Notes: https://doi.org/10.1007/978-3-032-10159-4_19 5
- 15b Zou W, Dong L, Pin A, Nilsson R, Kim M, Apinorasethkul O, Pakela J, Friberg A, Koger B, Labarbe R, Fuentes CL, Cengel K, Traneus E, Girdhani S, Koumenis C, Vander Stappen F, Diffenderfer E, Bradley J, Teo BK, Lin A. : Deliverable proton conformal FLASH radiotherapy treatment planning for head and neck re-irradiation patients 71 Radiotherapy and Oncology 216: 111349 December 2025 Notes: doi: 10.1016/j.radonc.2025.111349 5
- 118 Friberg AM, Tan HS, Diffenderfer ES, Verginadis I, Kim MM, Cengel K, Wiersma R, Dong L, Koumenis C, Teo BK, Zou W. : Physicochemical indication of the FLASH effect from shoot-through proton pencil beam scanning parameters delivered under ultra-high dose rates 72 Physics in Medicine and Biology 70(17):175002 August 2025 Notes: doi: 10.1088/1361-6560/adf58e 5
- 2bb Arpit M. Chhabra MD, Richard A. Amos MSc, FIPEM, Charles B. Simone II, MD, Adeel Kaiser MD, Luis A. Perles PhD, Huan Giap MD, PhD, Christopher L. Hallemeier MD, Jedediah E. Johnson PhD, Haibo Lin PhD, Andrew J. Wroe PhD, Eric S. Diffenderfer PhD, John A. Wolfgang PhD, Hideyuki Sakurai MD, Hsiao-Ming Lu PhD, Theodore S. Hong MD, Eugene J. Koay MD, PhD, Kazuki Terashima PhD, Pavel Vitek PhD, William G. Rule MD, Smith Jim Apisarnthanarax MD, Shahed N. Badiyan MD, Jason K. Molitoris MD, PhD, Michael Chuong MD, Romaine C. Nichols Jr. MD : Proton Beam Therapy for Pancreatic Tumors: A Consensus Statement from the Particle Therapy Cooperative Group Gastrointestinal Subcommittee 92 International Journal of Radiation Oncology • Biology • Physics 122(1) May 2025 Notes: doi: 10.1016/j.ijrobp.2024.12.020 5
- 174 Seyyedeh Azar Oliaei Motlagh, François Vander Stappen, Michele M Kim, Rudi Labarbe, Lucian Hotoiu, Arnaud Pin, Rasmus Nilsson, Erik Traneus, Keith A Cengel, Wei Zou, Boon-Keng Kevin Teo, Lei Dong, Eric S Diffenderfer : Verification of dose and dose rate for quality assurance of spread-out-Bragg-peak proton FLASH radiotherapy using machine log files 4c Medical Physics April 2025 Notes: DOI: 10.1002/mp.17792 5
- 1da Haiwei Ni, Zachary J Reitman, Wei Zou, Md Naushad Akhtar, Ritama Paul, Menggui Huang, Duo Zhang, Hao Zheng, Ruitao Zhang, Ruiying Ma, Gina Ngo, Lin Zhang, Eric S Diffenderfer, S Azar Oliaei Motlagh, Michele M Kim, Andy J Minn, Jay F Dorsey, Jessica B Foster, James Metz, Constantinos Koumenis, David G Kirsch, Yanqing Gong, Yi Fan : FLASH radiation reprograms lipid metabolism and macrophage immunity and sensitizes medulloblastoma to CAR-T cell therapy 57 Nature Cancer February 2025 Notes: DOI: 10.1038/s43018-025-00905-6 5
- 226 Ioannis I Verginadis, Anastasia Velalopoulou, Michele M Kim, Kyle Kim, Ioannis Paraskevaidis, Brett Bell, Seyyedeh Azar Oliaei Motlagh, Antoneta Karaj, Esha Banerjee, Giovanni Finesso, Charles-Antoine Assenmacher, Enrico Radaelli, Jiawei Lu, Yuewei Lin, Mary E Putt, Eric S Diffenderfer, Chandan Guha, Ling Qin, James M Metz, Amit Maity, Keith A Cengel, Constantinos Koumenis, Theresa M Busch : FLASH proton reirradiation, with or without hypofractionation, reduces chronic toxicity in the normal murine intestine, skin, and bone 64 Radiotherapy and Oncology January 2025 Notes: DOI: 10.1016/j.radonc.2025.110744 5
- 123 Ma Y, Zhang T, Selvaraj B, Shen J, Wei S, Cheng C, Gao H, Poulsen PR, Li H, Diffenderfer E, Schuemann J, Lin L, Morris Z, Durkee B, Hesser J, Lin H, Simone CB 2nd, Kang M, Wu H. : Advancing Proton FLASH Radiation Therapy: Innovations, Techniques, and Clinical Potentials 87 International Journal of Radiation Oncology • Biology • Physics 2025 Notes: doi: 10.1016/j.ijrobp.2025.05.076 5
- 55 Michele M. Kim, Eric S. Diffenderfer : Proton FLASH Radiotherapy 63 Proton Therapy Physics 2025 Notes: doi: https://doi.org/10.1201/9781032616858 5
- 104 Dixin Chen, Seyyedeh Azar Oliaei Motlagh, François Vander Stappen, Rudi Labarbe, Beryl Bell, Michele Kim, Boon‐Keng Kevin Teo, Lei Dong, Wei Zou, Eric Stanton Diffenderfer : Secondary neutron dosimetry for conformal FLASH proton therapy 6f Medical Physics April 2024 Notes: https://doi-org.proxy.library.upenn.edu/10.1002/mp.17050 6