Clinical Studies that are Actively Enrolling

Department of Radiation Oncology Clinical Studies that are Actively Enrolling
(updated on 9-19-2024)


For study consent forms and protocol, click here (SharePoint).  

For eligibility criteria of each study, click here (PennKey-protected).  

1. Study Title: Radiation Oncology Registry and Biosample Repository
Other Information: Registry / NCT02159742/ IRB 851881/ UPCC 11908
PI: Jay Dorsey, MD, PhD
Study Contact: Josh Bryer (jbryer@pennmedicine.upenn.edu | 445-800-5711)


2. Study Title: Phase III Study of Local or Systemic Therapy INtensification DIrected by PET in Prostate CAncer Patients with Post-ProstaTEctomy Biochemical Recurrence (INDICATE)
Other Information: INDICATE / NCT04423211 / EA8191/ IRB 848795
PI: Neha Vapiwala, MD
Study contact: Jhohanna Perez (Jhohanna.perez@pennmedicine.upenn.edu | 267-299-9643)

3. Study Title: Phase II Multi-Institutional Study of Low-Dose (4Gy) Palliative Radiotherapy in the Treatment of Symptomatic Bone metastases from Multiple Myeloma
Other Information: Palliative LDRT for Multiple Myeloma / NCT03858205 / IRB 833880 / UPCC 38419
PI: John Plastaras, MD, PhD
Study Contact: Jhohanna Perez (Jhohanna.perez@pennmedicine.upenn.edu | 267-299-9643)

4. Study Title: Phase III Randomized Trial of Proton Beam Therapy (PBT) Versus Intensity Modulated Photon Radiotherapy (IMRT) for The Treatment of Esophageal Cancer
Other Information: NRG GI006 / NCT03801876 /IRB 849913
PI: John Plastaras, MD, PhD
Study contact: Karen Tang (Karen.Tang1@pennmedicine.upenn.edu | 267-299-9618)

5. Study Title: Evaluation of Novel CT Imaging for Simulation on a Linear Accelerator
Other Information: Looking Glass / NCT06056063 / IRB 852966 / UPCC 02923
PI: Michelle Alonso Basanta, MD, PhD
Study contact: Karen Tang (Karen.Tang1@pennmedicine.upenn.edu | 267-299-9618)

6. Study Title: Use of Natural Language Processing ChatBot and Automated Continuous Activity Monitoring via Mobile Phones for Early Detection and Management of Symptoms in Patients Undergoing Cancer Treatment
Other Information: CAM2.0 / NCT05318027 / IRB 848797 / UPCC 18921
PI: Arun Goel, MD
Study contact: Jonathan Fu (Jonathan.Fu@pennmedicine.upenn.edu | 267-760-7636)

7. Study title: A Feasibility Study on the Use of 3 Dimensional Photography in Measuring and Assessing Radiation Dermatitis (Artec Leo)
Other Information: IRB 854572 / UPCC 369231
PI: Edgar Ben-Josef, MD
Study Contact: Marlowe Estioko (Marlowe.Estioko@pennmedicine.upenn.edu | 267-343-6483)

8. Study title: A Phase II Study of Shortened Course, Dose De-Intensified Adjuvant Radiotherapy Following Transoral Robotic Surgery (TORS) and Neck Dissection for HPV-Associated Oropharyngeal Squamous Cell Carcinoma (TORS 3.0)
Other Information: NCT05714657 / IRB 852738 /UPCC 06322
PI: Alexander Lin, MD
Study Contact: Taylor Siegal (Taylor.Siegal@pennmedicine.upenn.edu | 215-615-5644)

9. Study title: Adjuvant Proton Whole Pelvis Radiation Therapy For Treatment Of Post-Surgical Gynecologic Cancers (PROPS GYN)
Other Information: NCT05758688 / IRB 852760 /UPCC 27822
PI: Neil K. Taunk, MD, MSCTS
Study Contact: Snehal Somalwar (Snehal.Somalwar@pennmedicine.upenn.edu | 445-800-5697)

10. Study Title: Functional Lung Avoidance Radiation Therapy Using Hyperpolarized Xenon-129 MRI
Other Information: Xenon / NCT05302817/ IRB 849026 / UPCC 17522
PI: Steven Feigenberg, MD
Study Contact: Lisha Chen (Lisha.Chen@Pennmedicine.upenn.edu | 267-299-9668)

11. Study Title: Safety trial of antimicrobial therapy and precision radiation therapy in patients with oligo progressive non-small cell lung cancer
Other Information: Vanco / NCT03546829/ IRB 827551 / UPCC 08517
PI: Steven Feigenberg, MD
Study Contact: Lisha Chen (Lisha.Chen@Pennmedicine.upenn.edu | 267-299-9668)

12. Study Title: Virtual Reality to Promote Mindfulness and Relaxation prior to Radiation Simulation: A Prospective Pilot Feasibility Study
Other Information: Rocket VR / NCT06318338/ IRB 854756 / UPCC 14523
PI: Michael LaRiviere, MD
Study Contact: Emily Xiong (Emily.Xiong@Pennmedicine.upenn.edu | 267-299-9615)

13. Study Title: NRG-LU008: Phase III Prospective Randomized Trial of Primary Lung Tumor Stereotactic Body Radiation Therapy Followed by Concurrent Mediastinal Chemoradiation for Locally Advanced Non-Small Cell Lung Cancer
Other Information: NRG-LU008 / NCT05624996/ IRB 854727
PI: Jeffrey Bradley, MD
Study Contact: Lisha Chen (Lisha.Chen@Pennmedicine.upenn.edu | 267-299-9668)

14. Study Title: Cherenkov Imaging in Radiation Therapy- Application for Total Skin Electron (TSE) and other sites
Other Information: Cherenkov / IRB 827395 / UPCC 08917
PI: Timothy Zhu, PhD; John Plastaras, MD, PhD (Co-PI)
Study Contact: Lisha Chen (Lisha.Chen@Pennmedicine.upenn.edu | 267-299-9668