Koch Lab
Cameron J. Koch , Ph.D.
Professor
Radiation Oncology, University of Pennsylvania,
185 John Morgan Bldg.,
3620 Hamilton Walk,
Philadelphia, PA 19104-6702
Phone: 215-898-0073 | Fax: 215-898-0090
kochc@pennmedicine.upenn.edu
Areas of Interest and Expertise
Measurement of radioresistant hypoxic tumor cells in vivo using:
- immunohistochemistry and/or flow cytometry
- non-invasive imaging
- Quantification of tissue pO2
- Control and measurement of oxygen concentration and thiols
- Quantitative Fluorescence Microscopy
- Oxidative damage (primarily sulfydryl to disulfide) of DNA repair systems
- Effects of oxygen and oxygen radicals in biological or biochemical systems
- Development of fluorine-based PET imaging methods
- Automated chemical synthesis
- Mechanisms of action of radiation sensitizing and radiation protecting agents (survival or DNA damage)
- Models for competitive reactions of radiation modifying agents
- Metabolism of thiols and nitroheterocyclics (including cytotoxicity)
- Measurement of intracellular drug concentrations