11 17
1 15 15 11 3a
19 19 49 19 19 30

a2 Clinical Studies that are Actively Enrolling

19 19 19 31 19 65 19 19 49 31 31 19 19 19 19 19 45
86

Department of Radiation Oncology Clinical Studies that are Actively Enrolling
26 (updated on 8-26-2025)

2 c

dd For study consent forms and protocol, click here (SharePoint).  
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c7 For eligibility criteria of each study, click here (PennKey-protected).  
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5d 1. Study Title: Radiation Oncology Registry and Biosample Repository
49 Other Information: Registry / NCT02159742/ IRB 851881/ UPCC 11908
1f PI: Jay Dorsey, MD, PhD
d2 Study Contact: Saishravan Shyamsunder (Saishravan.Shyamsundar@Pennmedicine.upenn.edu | 267-299-9643)
2 c

cb 2. Study Title: Phase III Study of Local or Systemic Therapy INtensification DIrected by PET in Prostate CAncer Patients with Post-ProstaTEctomy Biochemical Recurrence (INDICATE)
46 Other Information: INDICATE / NCT04423211 / EA8191/ IRB 848795
1d PI: Neha Vapiwala, MD
d2 Study contact: Saishravan Shyamsunder (Saishravan.Shyamsundar@Pennmedicine.upenn.edu | 267-299-9643)
2 c

c0 3. Study Title: Phase II Multi-Institutional Study of Low-Dose (4Gy) Palliative Radiotherapy in the Treatment of Symptomatic Bone metastases from Multiple Myeloma
67 Other Information: Palliative LDRT for Multiple Myeloma / NCT03858205 / IRB 833880 / UPCC 38419
23 PI: John Plastaras, MD, PhD
d2 Study Contact: Saishravan Shyamsunder (Saishravan.Shyamsundar@Pennmedicine.upenn.edu | 267-299-9643)
2 c

bd 4. Study Title: Phase III Randomized Trial of Proton Beam Therapy (PBT) Versus Intensity Modulated Photon Radiotherapy (IMRT) for The Treatment of Esophageal Cancer
3e Other Information: NRG GI006 / NCT03801876 /IRB 849913
23 PI: John Plastaras, MD, PhD
d2 Study contact: Saishravan Shyamsunder (Saishravan.Shyamsundar@Pennmedicine.upenn.edu | 267-299-9643)
2 c

e9 5. Study Title: Use of Natural Language Processing ChatBot and Automated Continuous Activity Monitoring via Mobile Phones for Early Detection and Management of Symptoms in Patients Undergoing Cancer Treatment
49 Other Information: CAM2.0 / NCT05318027 / IRB 848797 / UPCC 18921
19 PI: Arun Goel, MD
d2 Study contact: Saishravan Shyamsunder (Saishravan.Shyamsundar@Pennmedicine.upenn.edu | 267-299-9643)
2 c

a0 6. Study Title: A Feasibility Study on the Use of 3 Dimensional Photography in Measuring and Assessing Radiation Dermatitis (Artec Leo)
33 Other Information: IRB 854572 / UPCC 369231
1f PI: Edgar Ben-Josef, MD
b8 Study Contact: Marlowe Estioko (Marlowe.Estioko@pennmedicine.upenn.edu | 267-343-6483)
2 c

fb 7. Study Title: A Phase II Study of Shortened Course, Dose De-Intensified Adjuvant Radiotherapy Following Transoral Robotic Surgery (TORS) and Neck Dissection for HPV-Associated Oropharyngeal Squamous Cell Carcinoma (TORS 3.0)
3f Other Information: NCT05714657 / IRB 852738 /UPCC 06322
1d PI: Alexander Lin, MD
bb Study Contact: Pradhita Kolluru (Pradhita.Kolluru@pennmedicine.upenn.edu | 215-964-0836)
2 c

96 8. Study Title: Adjuvant Proton Whole Pelvis Radiation Therapy For Treatment Of Post-Surgical Gynecologic Cancers (PROPS GYN)
3f Other Information: NCT05758688 / IRB 852760 /UPCC 27822
24 PI: Neil K. Taunk, MD, MSCTS
bb Study Contact: Pradhita Kolluru (Pradhita.Kolluru@pennmedicine.upenn.edu | 215-964-0836)
2 c

ac 9. Study Title: Safety trial of antimicrobial therapy and precision radiation therapy in patients with oligo progressive non-small cell lung cancer
47 Other Information: Vanco / NCT03546829/ IRB 827551 / UPCC 08517
21 PI: Steven Feigenberg, MD
a9 Study Contact: Karen Tang (Karen.Tang@Pennmedicine.upenn.edu | 267-299-9618)
2 c

f7 10. Study Title: NRG-LU008: Phase III Prospective Randomized Trial of Primary Lung Tumor Stereotactic Body Radiation Therapy Followed by Concurrent Mediastinal Chemoradiation for Locally Advanced Non-Small Cell Lung Cancer
3e Other Information: NRG-LU008 / NCT05624996/ IRB 854727
1f PI: Jeffrey Bradley, MD
a9 Study Contact: Karen Tang (Karen.Tang@Pennmedicine.upenn.edu | 267-299-9618)
2 c

8b 11. Study Title: Cherenkov Imaging in Radiation Therapy- Application for Total Skin Electron (TSE) and other sites
3e Other Information: Cherenkov / IRB 827395 / UPCC 08917
3d PI: Timothy Zhu, PhD; John Plastaras, MD, PhD (Co-PI)
ac Study Contact: Emily Xiong (Emily.Xiong@Pennmedicine.upenn.edu | 267-299-9615)
2 11
 
2 73
12. Study Title: Safety of Hypofractionated Whole-Pelvis Proton Therapy with HDR Boost
b7 Other Information: High-dose brachytherapy + hypofractionated whole-pelvis proton therapy for high or intermediate-risk prostate cancer / NCT06591819 / IRB 855972 / UPCC 08824
19 PI: Arun Goel, MD
b8 Study Contact: Marlowe Estioko (Marlowe.Estioko@pennmedicine.upenn.edu | 267-343-6483)
2 11
 
2 ac
13. Study Title: Phase I Safety Trial of Concurrent Adjuvant Immunotherapy and Radiation Therapy for the Treatment of Urothelial Bladder Cancer
99 Other Information: Radiation + post-cystectomy adjuvant immunotherapy for urothelial bladder cancer  / NCT06586255 / IRB 856691 / UPCC 16824
28 PI: John Christodouleas, MD, MPH
b8 Study Contact: Marlowe Estioko (Marlowe.Estioko@pennmedicine.upenn.edu | 267-343-6483)
2 11
 
2 95
14. Study Title: RAndomized Phase II/III Trial Of Consolidation Radiation + Immunotherapy for ES-SCLC: RAPTOR trial
42 Other Information: NRG-LU007 / IRB 857184
28 PI: Steven Feigenberg, MD  
ac Study Contact: Emily Xiong (Emily.Xiong@Pennmedicine.upenn.edu | 267-299-9615)
2 11
 
2 e6
15. Study Title: Cardiac RADIoablation versus repeat catheter Ablation: a pivotal randomized clinical Trial Evaluating safety and efficacy for patients with high-risk refractory Ventricular Tachycardia
43 Other Information: RADIATE-VT / Protocol Number VAR-2022-01
28 PI: Keith Cengel, MD, PhD  
d2 Study contact: Saishravan Shyamsunder (Saishravan.Shyamsundar@Pennmedicine.upenn.edu | 267-299-9643)
2 11
 
2 ab
16. Study Title: Phase III Trial of Single Fraction Stereotactic Radiosurgery (SRS) Versus Fractionated SRS (FSRS) for Intact Brain Metastases
3f Other Information: NRG-BN013 / NCT06500455 / IRB 858321
1b PI: Emily Lebow, MD
d2 Study contact: Saishravan Shyamsunder (Saishravan.Shyamsundar@Pennmedicine.upenn.edu | 267-299-9643)
2 11
 
2 c3
17. Study Title: SpaceIT Hydrogel System for Perirectal Spacing in Subjects with Low to Intermediate Risk Prostate Cancer Undergoing External Beam Radiotherapy (EBRT)
51 Other Information: NCT06451614 / IRB 858339 / NCI-2025-01558 / UPCC 09825
24 PI: Neil K. Taunk, MD, MSCTS
b8 Study Contact: Marlowe Estioko (Marlowe.Estioko@pennmedicine.upenn.edu | 267-343-6483)
2 11
 
2 13f
18. Study Title: A Phase 3 (Pivotal Stage) Study of NBTXR3 Activated by Investigator’s Choice of Radiotherapy Alone or Radiotherapy in Combination with Cetuximab for Platinum-based Chemotherapy-Ineligible Elderly Patients with Locally Advanced Head & Neck Squamous Cell Carcinoma.
2 36
Other Information: IRB 858884 / UPCC 06325
37 PI: John Nicholas Lukens, MD    
ac Study Contact: Emily Xiong (Emily.Xiong@Pennmedicine.upenn.edu | 267-299-9615)
2 f

 

2 ab
19. Study Title: Analysis of Toxicity in an Anal and Rectal Cancer Cohort Treated with Proton Therapy vs. Intensity Modulated Radiation Therapy
2 36
Other Information: IRB 857268 / UPCC 20224
20 PI: Karishma Khullar, MD
bb Study Contact: Pradhita Kolluru (Pradhita.Kolluru@pennmedicine.upenn.edu | 215-964-0836)
1f
19 19 19 31 19 1b
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