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26 Lingshu Yin, PhD

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79 Lingshu Yin photo 2f
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Assistant Professor of Clinical Radiation Oncology

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74 Department: Radiation Oncology

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Contact Information

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3f 3400 Civic Center Boulevard
63 2 West
Philadelphia, PA 19104 49

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Education

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  • 33 B.Sc., (Physics) 5e
    Nanjing University, Nanjing, China, 2006
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  • 3a Ph.D. (Medical Physics ) 5a
    University of British Columbia, 2011
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Description of Research Expertise

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Applications for Image Guided Proton Therapy with CBCT
3f Commissioning and absolute dosimetry for proton therapy
43 Monte Carlo simulation and beam modeling for proton therapy
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4f Software development for translational clinical applications including:
33 - Eclipse Scripting for clinical automation
35 - In-house dual energy CT calibration program
44 - Secondary MU check for pencil beam scanning proton therapy
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Description of Clinical Expertise

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Machine Quality Assurance
87 • Performed daily, monthly and annual QA for Varian Clinac 2300iX, Truebeam with OBI/CBCT/Calypso and Siemens Oncor machines
1a Treatment Planning
4e • Extensive treatment planning experience with Varian Eclipse system
64 o 3D-CRT, IMRT and RapidArc: CNS, GI/GU, Lung, GYN, Breast, Lymphoma, Sarcoma, Head and Neck
40 o Special treatment planning including electrons and TBI
2b Patient Treatment Quality Assurance
68 • Extensive experience with IMRT and RapidArc patient specific QA using MapCheck2 and ArcCheck
2e Cyberknife Robotic Radiosurgery System
54 • Performed daily, monthly and annual QA for Accuray Cyberknife VSI system
20 Brachytherapy Treatment
82 • Experience with Varian BrachyVision using Ir-192, performed monthly QA and source exchange calibration of the HDR unit
7b o Treatment planning and delivery of GYN cases with tandem and ovoid, vaginal cylinders, syed and capri applicators
2e General Clinical Practice and Projects
4c • Initial chart checking under the supervision of staff physicists
55 • On call physicist for after hour emergency treatments and machines issues
66 • Commissioning of RadCalc (Sun Nuclear) for secondary MU check of 3D-CRT, IMRT and RapidArc
80 • Commissioning of RapidArc (machine testing, treatment planning and patient specific QA) at the Pennsylvania Hospital
3e • Monthly QA for Siemens CT (Somatom Definition AS)
50 • Extensive experience with Varian Aria for paperless charting and R&V
78 • in vivo dosimetry measurements for Total Body Irradiation treatments using OneDose MOSFET and microStar OSLD
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2e CLINICAL EXPERIENCE – PROTON THERAPY
55 Acceptance and Commissioning of Cone Beam CT system for proton gantry machine
7e • Collaboration with IBA on acceptance and commissioning of the first proton therapy specific cone beam CT solution.
78 • Developing new tools and concepts for image guided proton therapy (IGPT) with CBCT using IBA imageX platform
36 Acceptance and Commissioning of adaPTinsightTM
63 • Collaboration with IBA on testing and feedback of this image guidance software platform
55 • Acceptance and commissioning as the first site implementing this platform
30 Proton Therapy Machine Quality Assurance
74 • Daily, monthly, annual machine QA for double scattering, uniform scanning and pencil beam scanning rooms
7d o Beam quality test (range, modulation and output) tests and absolute dose calibration with IBA Bluephantom and Zebra
8a o Absolute dose calibration (TRS 398) for pencil beam scanning proton therapy and spot pattern QA with Lynx scintillation detector
39 Proton Therapy Patient Specific Quality Assurance
73 • Double scattering patient QA: output and range/modulation measurement using IBA Bluephantom and MatrixX
5c • Uniform scanning and pencil beam scanning patient QA using IBA Zebra and MatrixX
1c Daily physics duties
40 • Provides support for dosimetry on treatment planning
44 • Initial, weekly chart checks and ends of treatment check
50 • Provides physics support for therapists during the 1st and 2nd shift
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Selected Publications

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  • d8 Yuting Peng, Youfang Lai, Lingshu Yin, Yujie Chi, Heng Li and Xun Jia : Investigating radical yield variations in FLASH and conventional proton irradiation via microscopic Monte Carlo simulations 42 Physics in Medicine & Biology 70(10) May 2025
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  • e2 Lingshu Yin, Daniel Sforza, Devin Miles, Masumi Umezawa, Kan Ota, Xun Jia and Heng Li : Commissioning of a 142.4 MeV ultra-high dose rate (UHDR) proton beamline in a synchrotron-based proton therapy system 46 Medical Physics 2025 Notes: Tentatively accepted
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  • de Yin L, Masumi U, Ota K, Sforza DM, Miles D, Rezaee M, Wong JW, Jia X, Li H : Feasibility of Synchrotron-Based Ultra-High Dose Rate (UHDR) Proton Irradiation with Pencil Beam Scanning for FLASH Research 39 Cancers (Basel) 16(1) : 221, Jan 2024
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  • e7 Yin L, Zou W, Kim M, Avery S, Wiersma R, Teo BK, Dong L, Diffenderfer E : Evaluation of two-voltage and three-voltage linear methods for deriving ion recombination correction factors in proton FLASH irradiation 67 IEEE Transactions on Radiation and Plasma Medical Sciences 6(3) : 263-270, Mar 2022
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  • f5 Kassaee A, Cheng C, Yin L, Zou W, Li T, Lin A, Swisher-McClure S, Lukens JN, Lustig RA, O'Reilly S, Dong L, Ms RH, Teo BK : Dual-Energy Computed Tomography Proton-Dose Calculation with Scripting and Modified Hounsfield Units 3a Int J Part Ther 8(1) : 62-72, Jun 2021
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  • fc Zou W, Diffenderfer ES, Cengel KA, Kim MM, Avery S, Konzer J, Cai Y, Boisseu P, Ota K, Yin L, Wiersma R, Carlson DJ, Fan Y, Busch TM, Koumenis C, Lin A, Metz JM, Teo BK, Dong L : Current delivery limitations of proton PBS for FLASH 3b Radiother Oncol 155 : 212-218, Feb 2021
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  • 104 Xie Y, Petzoldt J, Janssens G, O'Grady F, Yin L, Bentefour EH, Smeets J, Prieels D, Lustig RA, Lin A, Teo BK : Prompt gamma imaging for the identification of regional proton range deviations due to anatomic change in a heterogeneous region 3d Br J Radiol 93(1116) : 20190619, Dec 2020
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  • 12f O'Reilly S, Jain V, Huang Q, Cheng C, Teo BK, Yin L, Zhang M, Diffenderfer E, Li T, Levin W, Xiao Y, Dong L, Feigenberg S, Berman AT, Zou W : Dose to Highly Functional Ventilation Zones Improves Prediction of Radiation Pneumonitis for Proton and Photon Lung Cancer Radiation Therapy 49 Int J Radiat Oncol Biol Phys 107(1) : 79-87, May 2020
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  • d7 Lalonde A, Xie Y, Burgdorf B, O'Reilly S, Ingram WS, Yin L, Zou W, Dong L, Bouchard H, Teo BK : Influence of intravenous contrast agent on dose calculation in proton therapy using dual energy CT 3b Phys Med Biol 64(12) : 125024, Jun 2019
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  • d3 Arscott WT, Thompson RF, Yin L, Burgdorf B, Kirk M, Ben-Josef E : Stereotactic body proton therapy for liver tumors: Dosimetric advantages and their radiobiological and clinical implications 41 Phys Imaging Radiat Oncol 8 : 17-22, Nov 2018
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