Christoforos Thomas, PhD

Christoforos Thomas photo

Adjunct Assistant Professor of Radiation Oncology

Department: Radiation Oncology

Contact Information

University of Pennsylvania, Perelman School of Medicine
Department of Radiation Oncology
Smilow Center for Translational Research
Philadelphia, PA 19104
Email: christoforos.thomas@uphs.upenn.edu

Education

  • BS (Biology)
    Aristotle University, Thessaloniki, Greece, 1995
  • Ph.D. (Tumor Biology and Physiology)
    Laboratory of Physiology, University of Ioannina, Medical School, Greece, 2004

Selected Publications

  • Rajapaksa Gayani, Thomas Christoforos, Gustafsson Jan-Åke : Estrogen signaling and unfolded protein response in breast cancer. The Journal of steroid biochemistry and molecular biology 163 : 45-50, Oct 2016
  • Bado Igor, Nikolos Fotis, Rajapaksa Gayani, Gustafsson Jan-Åke, Thomas Christoforos : ERβ decreases the invasiveness of triple-negative breast cancer cells by regulating mutant p53 oncogenic function. Oncotarget 7(12) : 13599-611, Mar 2016
  • Thomas Christoforos, Gustafsson Jan-Åke : Estrogen receptor mutations and functional consequences for breast cancer. Trends in endocrinology and metabolism: TEM 26(9) : 467-76, Sep 2015
  • Rajapaksa G, Nikolos F, Bado I, Clarke R, Gustafsson J-Å, Thomas C : ERβ decreases breast cancer cell survival by regulating the IRE1/XBP-1 pathway. Oncogene 34(31) : 4130-41, Jul 2015
  • Said Rabih, Ye Yang, Hong David S, Janku Filip, Fu Siqing, Naing Aung, Wheler Jennifer J, Kurzrock Razelle, Thomas Christoforos, Palmer Gary A, Hess Kenneth R, Aldape Kenneth, Tsimberidou Apostolia M : Characteristics and survival of patients with advanced cancer and p53 mutations. Oncotarget 5(11) : 3871-9, Jun 2014
  • Nikolos Fotis, Thomas Christoforos, Rajapaksa Gayani, Bado Igor, Gustafsson Jan-Åke : ERβ regulates NSCLC phenotypes by controlling oncogenic RAS signaling. Molecular cancer research : MCR 12(6) : 843-54, Jun 2014
  • Thomas Christoforos, Rajapaksa Gayani, Nikolos Fotis, Hao Ruixin, Katchy Anne, McCollum Catherine W, Bondesson Maria, Quinlan Phil, Thompson Alastair, Krishnamurthy Savitri, Esteva Francisco J, Gustafsson Jan-Åke : ERbeta1 represses basal breast cancer epithelial to mesenchymal transition by destabilizing EGFR. Breast cancer research : BCR 14(6) : R148, Nov 2012
  • Thomas Christoforos, Gustafsson Jan-Åke : Targeting PES1 for restoring the ERα/ERβ ratio in breast cancer. The Journal of clinical investigation 122(8) : 2771-3, Aug 2012
  • Thomas CG, Gustafsson, JA : Not enough evidence to include ESR1 amplification Nat Rev Cancer 11 : 823, Nov 2011 Notes: Epub 24 Oct 2011
  • Alvarez-Baron Claudia P, Jonsson Philip, Thomas Christoforos, Dryer Stuart E, Williams Cecilia : The two-pore domain potassium channel KCNK5: induction by estrogen receptor alpha and role in proliferation of breast cancer cells. Molecular endocrinology (Baltimore, Md.) 25(8) : 1326-36, Aug 2011