Welcome to the Department of Radiation Oncology
Message from James M. Metz, MD — Chairman
Penn Radiation Oncology is dedicated to a three-part mission of excellence in patient care, basic and translational research, and the education of residents and students. We are committed to delivering excellence in every area and as such we steadfastly believe that “Excellence is Standard.”
Penn Radiation Oncology is one of the most comprehensive radiation oncology programs in the world. The outstanding faculty and staff, combined with Penn’s extensive collection of advanced technology, gives patients access to nearly every treatment option available for their cancer. The broad range of radiation treatments available include proton therapy, intensity-modulated radiation therapy (IMRT), high-dose rate (HDR) and low-dose rate brachytherapy, partial breast irradiation, stereotactic radiosurgery (SRS), and Gamma Knife radiation. With the Abramson Cancer Center of the University of Pennsylvania, Penn Radiation Oncology provides patient care at the Ruth and Raymond Perelman Center for Advanced Medicine and seven community-based sites.
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- Targeting Stromal Cells May Help Overcome Treatment Resistance in Glioblastoma
February 26, 2020
From Penn Medicine News Release: The deadly brain cancer glioblastoma (GBM) is often resistant to chemotherapy and radiation, but new research from the Perelman School of Medicine and Penn’s Abramson Cancer Center shows targeting stromal cells – the cells that serve as the connective tissue of the organs – may be an effective way of overcoming that resistance. Specifically, the researchers found that GBM causes these stromal cells to act like stem cells, naturally resisting attempts to kill them and promoting tumor growth instead. They also identified the pathway that makes this all possible and showed that blocking that pathway makes cancer vulnerable in a lab setting. Read senior author, Yi Fan, MD, PhD's, article in Science Translational Medicine.
Penn Medicine News Update:
Penn Medicine Shows Giving Entire Course of Radiation Treatment in Less Than a Second is Feasible
Researchers in the Roberts Proton Therapy Center have shown that using proton radiation to generate the dosage needed to theoretically give a cancer patient their entire course of radiotherapy in less than a second is feasible. The work was led by James M. Metz, MD, director of the Roberts Proton Therapy Center and chair of Radiation Oncology, Constantinos Koumenis, PhD, a professor of Research Oncology, Keith A. Cengel, MD, PhD, an associate professor of Radiation Oncology, and Eric Diffenderfer, PhD, an assistant professor of Radiation Oncology. Read the report published today in the International Journal of Radiation Oncology*Biology*Physics
Researchers Identify in Mouse Models a New Way to Make Cancer Self Destruct
A research team in the Perelman School of Medicine of the University of Pennsylvania, led by, Constantinos Koumenis, PhD, have identified a new pathway that works as a partner to MYC and may be its Achilles’ Heel. The pathway involves a protein called ATF4, and when it’s blocked, it can cause cancer cells to produce too much protein and die. These findings in cell lines and mouse models could point the way toward a new therapeutic approach as inhibitors that can block synthesis of ATF4 already exist. Published in Nature Cell Biology.
Medical Physics Graduate Programs Relaunched
The Master of Medical Physics and Certificate in Medical Physics programs are excited to welcome our first class to our new home in the Perelman School of Medicine for Fall semester 2019.
Please see our new Medical Residency Brochure