We are focused on the genetic mechanisms of pathogenesis and antibiotic resistance, mainly of Vibrio cholerae and some Enterobacteriaceae species, specifically researching the interaction between hosts, gut microbiota, and subsequent genetic modulation and the involvement of quorum sensing componentry.
Research
Zhu laboratory investigates how pathogenic bacteria sense and respond to their environments and communicate both with one another and with members of the gut microbiome. We focus on Vibrio cholerae, the causative agent of cholera, as well as several clinically relevant Enterobacteriaceae species, to uncover the chemical signals these pathogens encounter during infection of the human intestinal tract and how such cues are translated into changes in gene expression. Our research has identified multiple host-derived small molecules that V. cholerae recognizes as indicators of intestinal entry, triggering activation of its virulence program. We have also defined the role of quorum sensing—the bacterial communication system that uses small molecules to assess population density—in coordinating V. cholerae virulence and biofilm development.
Ongoing studies examine how V. cholerae senses and responds to signaling molecules produced by neighboring members of the gut microbiota during infection. To address these questions, we integrate genetic screens, biochemical analyses, animal models, and deep sequencing approaches. Through this research, we aim to elucidate how bacterial pathogens employ complex regulatory networks to navigate the “hide-and-seek” dynamics of host–pathogen interactions. Ultimately, our goal is to deepen understanding of V. cholerae and other enteric bacterial pathogens and to inform the development of new strategies for combating diarrheal diseases.
Publications
Lab Directions
