Program Project Grant (P01) / Biological Mechanisms involved with PDT in the treatment of MPM
NIH Grant P01-CA087971
Principal Investigators:
- Theresa Busch, PhD, University of Pennsylvania (Co-PI)
- Keith Cengel, MD, PhD, University of Pennsylvania (Co-PI)
Project Leaders:
- Sunil Singhal, MD, University of Pennsylvania (Project 1)
- Steven M. Albelda, MD, University of Pennsylvania (Project 2)
- Keith Cengel, MD, PhD, University of Pennsylvania (Project 3)
- Theresa M. Busch, PhD, University of Pennsylvania (Project 4)
Project Overview:
Photodynamic therapy (PDT) relies on a light sensitive drug (a photosensitizer) to damage malignant or otherwise diseased tissues in areas where this photosensitizer is excited by specific wavelengths of visible light. The presence of oxygen in the treated tissues is also important for PDT with many clinically-utilized photosensitizers. PDT is well suited to the intraoperative setting, where it can be used to treat unresectable disease and surgical margins. This program project grant (P01) is investigating the local and systemic mechanisms through which PDT interacts with the surgical environment to determine local control and long-term outcome. The reduction of disease burden by surgery is undoubtedly an advantage, yet the accompanying induction of pro-inflammatory cytokines and survival signaling could alter the immunologic, molecular and physiologic environment to which PDT is delivered. For the clinical study of surgery-PDT interactions, we use as our model intraoperative PDT of malignant pleural mesothelioma (MPM). The overall, long-term goal of this P01 is to maximize the potential clinical utility of surgery/PDT as a treatment modality. We are conducting a randomized clinical trial to elucidate the potential benefit of PDT in this setting.
This P01 (Co-PIs, Drs. Busch and Cengel) consists of four highly integrated projects: Project 1 (Sunil Singhal) is conducting a prospective randomized Phase II clinical trial looking at surgery for radical pleurectomy, with and without intraoperative PDT to the pleura of the lung. Project 2 (Dr. Steven Albelda) is characterizing anti-tumor immune responses following surgery and pleural PDT (pPDT). Project 3 (Dr. Keith Cengel) is exploring baseline and surgically-induced activation of survival signaling pathways in patients. Project 4 (Dr. Theresa Busch) is studying the vascular microenvironment of MPM in patients receiving surgery/PDT.
Overall, this P01 provides the framework to align a highly significant clinical trial with investigations in clinical specimens and animal models that will serve to inform the future direction of intraoperative PDT. The work is performed by a multidisciplinary team of physicians, physicists and scientists, each an expert in his or her respective field. Thanks to the continuous funding of this P01 mechanism by the NIH since 2001, as evidenced by our publications, we have uniquely contributed to the body of clinical and scientific knowledge in many areas of PDT. These include, but are not limited to investigations in the study of pleural PDT, tumor microenvironment, PDT-induced molecular signaling, animal models of PDT delivery, PDT light dosimetry, and optical-based monitoring of tumor physiological and photophysical properties.
Project 1: A Randomized Clinical Trial for Patients with Malignant Pleural Mesothelioma comparing Radical Pleurectomy Alone to Radical Pleurectomy plus Photodynamic Therapy
- Sunil Singhal, MD, University of Pennsylvania (Leader)
Project 2: Evaluation and Augmentation of Anti-tumoral Immune Responses Induced by Surgery followed by pPDT in Mesothelioma
- Steven M. Albelda, MD, University of Pennsylvania (Leader)
Project 3: Evaluating and Modulating the Impact of Surgically-Induced Cytokines on Tumor Response to Photodynamic Therapy
- Keith Cengel, MD, PhD, University of Pennsylvania (Leader)
Project 4: Understanding and Optimizing Vascular Response to Intraoperative PDT of Malignant Mesothelioma
- Theresa M. Busch, PhD, University of Pennsylvania (Leader)
- Arjun G. Yodh, PhD, University of Pennsylvania (Co-Investigator)
Core A: PDT Physics Core
- Timothy C. Zhu, PhD, University of Pennsylvania (Leader)
Core B: Animal and Pathology Core
- Theresa Busch, PhD, University of Pennsylvania (Leader)
- Amy C. Durham, MS, VMD, DACVP, University of Pennsylvania (Co-Investigator)
Core C: Biostatistics and Data Coordinating Core (BDCC)
- Mary C. Putt, PhD, ScD, University of Pennsylvania (Leader)
- Rosemarie Mick, MS, University of Pennsylvania (Co-Investigator)
- E. Paul Wileyto, PhD, University of Pennsylvania(Co-Investigator)
Core D: Administrative Core
- Theresa Busch, PhD, University of Pennsylvania (Co-PI)
- Keith Cengel, MD, PhD, University of Pennsylvania (Co-PI)
Two subcontracts further support the goals of this P01. A subcontract under Project 1 to Roswell Park Cancer Institute provides for the treatment of additional patients on the clinical trial. To support some aspects of the human immunology studies, Project 2 contains a subcontract to The Wistar Institute (Emmanouil Papasavvas, Ph.D. and Luis Montaner, D.V.M., D.Phil.).
Publications
- Grossman CE, Carter SL, Czupryna J, Wang L, Putt ME, Busch TM. Fluence Rate Differences in Photodynamic Therapy Efficacy and Activation of Epidermal Growth Factor Receptor after Treatment of the Tumor-Involved Murine Thoracic Cavity. Int J Mol Sci. 2016 Jan 14;17(1). pii: E101. doi: 10.3390/ijms17010101. PubMed PMID: 26784170.
- Ghogare AA, Miller JM, Mondal B, Lyons AM, Cengel KA, Busch TM, Greer A. Fluorinated Photodynamic Therapy Device Tips and their Resistance to Fouling for In Vivo Sensitizer Release. Photochem Photobiol. 2016 Jan;92(1):166-72. doi: 10.1111/php.12538. Epub 2015 Nov 4. PubMed PMID: 26451683.
- Penjweini R, Liu B, Kim MM, Zhu TC. Explicit dosimetry for 2-(1-hexyloxyethyl)-2-devinyl pyropheophorbide-a-mediated photodynamic therapy: macroscopic singlet oxygen modeling. J Biomed Opt. 2015 Dec 1;20(12):128003. doi: 10.1117/1.JBO.20.12.128003. PubMed PMID: 26720883; PubMed Central PMCID: PMC4698734.
- Gallagher-Colombo SM, Quon H, Malloy KM, Ahn PH, Cengel KA, Simone CB 2nd, Chalian AA, O'Malley BW, Weinstein GS, Zhu TC, Putt ME, Finlay JC, Busch TM. Measuring the Physiologic Properties of Oral Lesions Receiving Fractionated Photodynamic Therapy. Photochem Photobiol. 2015 Sep-Oct;91(5):1210-8. doi: 10.1111/php.12475. Epub 2015 Jul 2. PubMed PMID: 26037487; PubMed Central PMCID: PMC4560604.
- Gallagher-Colombo SM, Miller J, Cengel KA, Putt ME, Vinogradov SA, Busch TM. Erlotinib Pretreatment Improves Photodynamic Therapy of Non-Small Cell Lung Carcinoma Xenografts via Multiple Mechanisms. Cancer Res. 2015 Aug 1;75(15):3118-26. doi: 10.1158/0008-5472.CAN-14-3304. Epub 2015 Jun 8. PubMed PMID: 26054596; PubMed Central PMCID: PMC4526424.
- Han SW, Zhong H, Putt M. An Efficient Operator for the Change Point Estimation in Partial Spline Model. Commun Stat Simul Comput. 2015 May;44(5):1171-1186. PubMed PMID: 25705072; PubMed Central PMCID: PMC4334167.
- Ghosh G, Minnis M, Ghogare AA, Abramova I, Cengel KA, Busch TM, Greer A. Photoactive fluoropolymer surfaces that release sensitizer drug molecules. J Phys Chem B. 2015 Mar 12;119(10):4155-64. doi: 10.1021/acs.jpcb.5b00808. Epub 2015 Feb 26. PubMed PMID: 25686407; PubMed Central PMCID: PMC4476300.
- Zhu TC, Liang X, Kim MM, Finlay JC, Dimofte A, Rodriguez C, Simone CB 2nd, Friedberg JS, Cengel KA. An IR Navigation System for Pleural PDT. Front Phys. 2015 Mar;3. pii: 9. PubMed PMID: 25995987; PubMed Central PMCID: PMC4435962.
- Zhu TC, Kim MM, Liang X, Finlay JC, Busch TM. <i>In-vivo</i> singlet oxygen threshold doses for PDT. Photonics Lasers Med. 2015 Feb;4(1):59-71. PubMed PMID: 25927018; PubMed Central PMCID: PMC4410434.
- Simone CB 2nd, Cengel KA. Photodynamic therapy for lung cancer and malignant pleural mesothelioma. Semin Oncol. 2014 Dec;41(6):820-30. doi: 10.1053/j.seminoncol.2014.09.017. Epub 2014 Oct 7. Review. PubMed PMID: 25499640; PubMed Central PMCID: PMC4272687.
- Han SW, Mesquita RC, Busch TM, Putt ME. A Method for Choosing the Smoothing Parameter in a Semi-parametric Model for Detecting Change-points in Blood Flow. J Appl Stat. 2014;41(1):26-45. PubMed PMID: 24459325; PubMed Central PMCID: PMC3896242.
- Liang X, Wang KK, Zhu TC. Feasibility of interstitial diffuse optical tomography using cylindrical diffusing fibers for prostate PDT. Phys Med Biol. 2013 May 21;58(10):3461-80. doi: 10.1088/0031-9155/58/10/3461. Epub 2013 Apr 30. PubMed PMID: 23629149; PubMed Central PMCID: PMC3759155.
- Sharikova AV, Finlay JC, Dimofte A, Zhu TC. A robotic multi-channel platform for interstitial photodynamic therapy. Proc SPIE Int Soc Opt Eng. 2013 Mar 13;8568:85680Q. PubMed PMID: 25914794; PubMed Central PMCID: PMC4407373.
- Meo JL, Zhu T. Monte Carlo simulation of light fluence calculation during pleural PDT. Proc SPIE Int Soc Opt Eng. 2013 Feb 2;8568. pii: 85680U. PubMed PMID: 25999640; PubMed Central PMCID: PMC4437723.
- Lambson K, Liang X, Sharikova AV, Zhu TC, Finlay JC. A Theoretical and Experimental Examination of Fluorescence in Enclosed Cavities. Proc SPIE Int Soc Opt Eng. 2013 Feb 2;8568. pii: 85680B. PubMed PMID: 25999641; PubMed Central PMCID: PMC4437726.
- Liu B, Kim MM, Zhu TC. A theoretical comparison of macroscopic and microscopic modeling of singlet oxygen during Photofrin and HPPH mediated-PDT. Proc SPIE Int Soc Opt Eng. 2013 Feb 2;8568. pii: 856805. PubMed PMID: 25999642; PubMed Central PMCID: PMC4437727.
- Kim MM, Zhu TC. A novel near real-time laser scanning device for geometrical determination of pleural cavity surface. Proc SPIE Int Soc Opt Eng. 2013 Feb 2;8568. pii: 856812. PubMed PMID: 25999643; PubMed Central PMCID: PMC4437728.
- McMillan DD, Chen D, Kim MM, Liang X, Zhu TC. Parameter Determination for Singlet Oxygen Modeling of BPD-Mediated PDT. Proc SPIE Int Soc Opt Eng. 2013 Feb 2;8568. pii: 856810. PubMed PMID: 25999644; PubMed Central PMCID: PMC4437730.
- Sharikova AV, Finlay JC, Liang X, Zhu TC. PDT dose dosimetry for pleural photodynamic therapy.Proc SPIE Int Soc Opt Eng. 2013 Feb 2;8568. pii: 856817. PubMed PMID: 25999645; PubMed Central PMCID: PMC4437732.
- Dimofte A, Sharikova AV, Meo JL, Simone CB 2nd, Friedberg JS, Zhu TC. Light dosimetry and dose verification for pleural PDT. Proc SPIE Int Soc Opt Eng. 2013 Feb 2;8568. pii: 85680V. PubMed PMID: 25999646; PubMed Central PMCID: PMC4437736.
- Zhu TC, Kim MM, Liang X, Liu B, Meo JL, Finlay JC, Dimofte A, Rodriguez C, Simone CB 2nd, Cengel K, Friedberg JS. Real-time treatment feedback guidance of Pleural PDT. Proc SPIE Int Soc Opt Eng. 2013 Feb 2;8568. pii: 85680O. PubMed PMID: 25999647; PubMed Central PMCID: PMC4437737.
- Simone CB II, Friedberg JS, Glatstein E, Stevenson JP, Sterman DH, Hahn SM, Cengel KA. Photodynamic therapy for the treatment of non-small cell lung cancer. Int J Pathol Clin Med. 2013;33(3):185-197
- Simone, CB, Friedberg, JS, Cengel, KA: Photodynamic Therapy for Pleural Malignancies. Handbook of Photomedicine. Hamblin, MR, Sharma SK (eds.). Taylor & Francis, 2013.
- Gallagher-Colombo SM, Busch TM. Vascular and cellular targeted photodynamic therapy. Handbook of Photomedicine. Hamblin and Huang (eds.). Taylor & Francis Books, Inc .2013.
- Edmonds C, Hagan S, Gallagher-Colombo SM, Busch TM, Cengel KA. Photodynamic therapy activated signaling from epidermal growth factor receptor and STAT3: Targeting survival pathways to increase PDT efficacy in ovarian and lung cancer. Cancer Biol Ther. 2012 Dec;13(14):1463-70. doi: 10.4161/cbt.22256. Epub 2012 Sep 17. PubMed PMID: 22986230; PubMed Central PMCID: PMC3542238.
- Friedberg JS. Radical pleurectomy and photodynamic therapy for malignant pleural mesothelioma.Ann Cardiothorac Surg. 2012 Nov;1(4):472-80. doi: 10.3978/j.issn.2225-319X.2012.11.14. PubMed PMID: 23977539; PubMed Central PMCID: PMC3741797.
- Dimofte A, Finlay JC, Liang X, Zhu TC. Determination of optical properties in heterogeneous turbid media using a cylindrical diffusing fiber. Phys Med Biol. 2012 Oct 7;57(19):6025-46. doi: 10.1088/0031-9155/57/19/6025. Epub 2012 Sep 12. PubMed PMID: 22968172; PubMed Central PMCID: PMC3444568.
- Cengel K. Adapting preclinical concepts for use in clinical trials of serosal and interstitial photodynamic therapy. J Natl Compr Canc Netw. 2012 Oct 1;10 Suppl 2:S18-22. PubMed PMID: 23055208.
- Friedberg JS. Photodynamic therapy for malignant pleural mesothelioma. J Natl Compr Canc Netw. 2012 Oct 1;10 Suppl 2:S75-9. PubMed PMID: 23055222.
- Gallagher-Colombo SM, Maas AL, Yuan M, Busch TM. Photodynamic therapy-induced angiogenic signaling: consequences and solutions to improve therapeutic response. Isr J Chem. 2012 Sep 1;52(8-9):681-690. PubMed PMID: 26109742; PubMed Central PMCID: PMC4476543.
- Friedberg JS, Culligan MJ, Mick R, Stevenson J, Hahn SM, Sterman D, Punekar S, Glatstein E, Cengel K. Radical pleurectomy and intraoperative photodynamic therapy for malignant pleural mesothelioma. Ann Thorac Surg. 2012 May;93(5):1658-65; discussion 1665-7. doi: 10.1016/j.athoracsur.2012.02.009. PubMed PMID: 22541196; PubMed Central PMCID: PMC4394024.
- Maas AL, Carter SL, Wileyto EP, Miller J, Yuan M, Yu G, Durham AC, Busch TM. Tumor vascular microenvironment determines responsiveness to photodynamic therapy. Cancer Res. 2012 Apr 15;72(8):2079-88. doi: 10.1158/0008-5472.CAN-11-3744. Epub 2012 Feb 28. PubMed PMID: 22374982; PubMed Central PMCID: PMC3328659.
- Simone CB 2nd, Friedberg JS, Glatstein E, Stevenson JP, Sterman DH, Hahn SM, Cengel KA.Photodynamic therapy for the treatment of non-small cell lung cancer. J Thorac Dis. 2012 Feb;4(1):63-75. doi: 10.3978/j.issn.2072-1439.2011.11.05. PubMed PMID: 22295169; PubMed Central PMCID: PMC3256541.
- Mesquita RC, Han SW, Miller J, Schenkel SS, Pole A, Esipova TV, Vinogradov SA, Putt ME, Yodh AG, Busch TM. Tumor blood flow differs between mouse strains: consequences for vasoresponse to photodynamic therapy. PLoS One. 2012;7(5):e37322. doi: 10.1371/journal.pone.0037322. Epub 2012 May 18. PubMed PMID: 22624014; PubMed Central PMCID: PMC3356280.
- Du KL, Zhu TC, Finlay JC, Busch TM: Photodynamic therapy of prostate cancer. Oxidative Stress in Cancer Biology and Therapy. DR Spitz, KJ Dornfeld, K Krishnan, D Gius (eds.). Humana Press/ Springer Science, 2012.
- Quon H, Simone, II, CB, Cengel K, Finlay JC, Zhu TC, Busch TM : Photodynamic therapy in the management of cancer. Principles and Practice of Radiation Oncology. Perez and Brady (eds.). Lippincott Williams & Wilkins, 2012.
- Sandell JL, Zhu TC. A review of in-vivo optical properties of human tissues and its impact on PDT. J Biophotonics. 2011 Nov;4(11-12):773-87. Review. PubMed PMID: 22167862; PubMed Central PMCID: PMC3321368.
- Grossman CE, Pickup S, Durham A, Wileyto EP, Putt ME, Busch TM. Photodynamic therapy of disseminated non-small cell lung carcinoma in a murine model. Lasers Surg Med. 2011 Sep;43(7):663-75. doi: 10.1002/lsm.21102. PubMed PMID: 22057494; PubMed Central PMCID: PMC3676899.
- Agostinis P, Berg K, Cengel KA, Foster TH, Girotti AW, Gollnick SO, Hahn SM, Hamblin MR, Juzeniene A, Kessel D, Korbelik M, Moan J, Mroz P, Nowis D, Piette J, Wilson BC, Golab J.Photodynamic therapy of cancer: an update. CA Cancer J Clin. 2011 Jul-Aug;61(4):250-81. doi: 10.3322/caac.20114. Epub 2011 May 26. Review. PubMed PMID: 21617154; PubMed Central PMCID: PMC3209659.
- Friedberg JS, Mick R, Culligan M, Stevenson J, Fernandes A, Smith D, Glatstein E, Hahn SM, Cengel K. Photodynamic therapy and the evolution of a lung-sparing surgical treatment for mesothelioma.Ann Thorac Surg. 2011 Jun;91(6):1738-45. doi: 10.1016/j.athoracsur.2011.02.062. PubMed PMID: 21619970.
- Friedberg JS. Photodynamic therapy for malignant pleural mesothelioma: the future of treatment?Expert Rev Respir Med. 2011 Feb;5(1):49-63. doi: 10.1586/ers.11.1. PubMed PMID: 21348586.
- Cengel, KA, Apisarnthanarax, S, Hahn, SM: Photodynamic Therapy. Principles and Practice of Oncology, 9th edition. DeVita, VT, Laurence, TS, Rosenberg, SA (eds.). 2011.
- Kundu P and Zhu TC: Spiral, spatially optimized light blanket for intraoperative PDT, Proc 13th IPA world congress. Herwig Kostron (eds), MEDIMOND s.r.l. pages 109-113, December 2011.
- Mesquita RC, Skuli N, Kim MN, Liang J, Schenkel S, Majmundar AJ, Simon MC, Yodh AG.Hemodynamic and metabolic diffuse optical monitoring in a mouse model of hindlimb ischemia.Biomed Opt Express. 2010 Oct 15;1(4):1173-1187. PubMed PMID: 21258539; PubMed Central PMCID: PMC3018079.
- Du KL, Both S, Friedberg JS, Rengan R, Hahn SM, Cengel KA. Extrapleural pneumonectomy, photodynamic therapy and intensity modulated radiation therapy for the treatment of malignant pleural mesothelioma. Cancer Biol Ther. 2010 Sep 1;10(5):425-9. Epub 2010 Sep 8. PubMed PMID: 20699634.
- Busch TM, Wang HW, Wileyto EP, Yu G, Bunte RM. Increasing damage to tumor blood vessels during motexafin lutetium-PDT through use of low fluence rate. Radiat Res. 2010 Sep;174(3):331-40. doi: 10.1667/RR2075.1. PubMed PMID: 20726728; PubMed Central PMCID: PMC2995951.
- Friedberg JS, Cengel KA. Pleural malignancies. Semin Radiat Oncol. 2010 Jul;20(3):208-14. doi: 10.1016/j.semradonc.2010.01.009. Review. PubMed PMID: 20685584.
- Wang KK, Finlay JC, Busch TM, Hahn SM, Zhu TC. Explicit dosimetry for photodynamic therapy: macroscopic singlet oxygen modeling. J Biophotonics. 2010 Jun;3(5-6):304-18. doi: 10.1002/jbio.200900101. PubMed PMID: 20222102; PubMed Central PMCID: PMC3071971.
- Busch TM. Hypoxia and perfusion labeling during photodynamic therapy. Methods Mol Biol. 2010;635:107-20. doi: 10.1007/978-1-60761-697-9_8. PubMed PMID: 20552343.
- Busch TM, Xing X, Yu G, Yodh A, Wileyto EP, Wang HW, Durduran T, Zhu TC, Wang KK. Fluence rate-dependent intratumor heterogeneity in physiologic and cytotoxic responses to Photofrin photodynamic therapy. Photochem Photobiol Sci. 2009 Dec;8(12):1683-93. doi: 10.1039/b9pp00004f. Epub 2009 Oct 15. PubMed PMID: 20024165; PubMed Central PMCID: PMC2834171.
- Hill-Kayser CE, Avery S, Mesina CF, James P, Friedberg JS, Cengel K, Lin LL, Hahn SM, Rengan R.Hemithoracic radiotherapy after extrapleural pneumonectomy for malignant pleural mesothelioma: a dosimetric comparison of two well-described techniques. J Thorac Oncol. 2009 Nov;4(11):1431-7. doi: 10.1097/JTO.0b013e3181b9eb85. PubMed PMID: 19745767.
- Dubroff JG, Alavi A, Friedberg JS, Cengel KA. Postsurgical atypical F-18 fluorodeoxyglucose positron emission tomography uptake. Clin Nucl Med. 2009 Nov;34(11):808-10. doi: 10.1097/RLU.0b013e3181b81e30. PubMed PMID: 19851183; PubMed Central PMCID: PMC3530922.
- Cerniglia GJ, Pore N, Tsai JH, Schultz S, Mick R, Choe R, Xing X, Durduran T, Yodh AG, Evans SM, Koch CJ, Hahn SM, Quon H, Sehgal CM, Lee WM, Maity A. Epidermal growth factor receptor inhibition modulates the microenvironment by vascular normalization to improve chemotherapy and radiotherapy efficacy. PLoS One. 2009 Aug 6;4(8):e6539. doi: 10.1371/journal.pone.0006539. PubMed PMID: 19657384; PubMed Central PMCID: PMC2716529.
- Wang KK, Zhu TC. Reconstruction of in-vivo optical properties for human prostate using interstitial diffuse optical tomography. Opt Express. 2009 Jul 6;17(14):11665-72. PubMed PMID: 19582081; PubMed Central PMCID: PMC3276880.
- Friedberg JS. Photodynamic therapy as an innovative treatment for malignant pleural mesothelioma.Semin Thorac Cardiovasc Surg. 2009 Summer;21(2):177-87. doi: 10.1053/j.semtcvs.2009.07.001. Review. PubMed PMID: 19822291.
- Busch T. Approaches toward combining photodynamic therapy with pharmaceuticals that alter vascular microenvironment. Retina. 2009 Jun;29(6 Suppl):S36-8. doi: 10.1097/IAE.0b013e3181ad25e8. PubMed PMID: 19553798.
- Busch T, Cengel KA, Finlay J. Pheophorbide a as a photosensitizer in photodynamic therapy: in vivo considerations. Cancer Biol Ther. 2009 Mar 15;8(6):540-2. doi: 10.4161/cbt.8.6.8067. Epub 2009 Mar 15. PubMed PMID: 19252412.
- Patel H, Mick R, Finlay J, Zhu TC, Rickter E, Cengel KA, Malkowicz SB, Hahn SM, Busch TM.Motexafin lutetium-photodynamic therapy of prostate cancer: short- and long-term effects on prostate-specific antigen. Clin Cancer Res. 2008 Aug 1;14(15):4869-76. doi: 10.1158/1078-0432.CCR-08-0317. PubMed PMID: 18676760; PubMed Central PMCID: PMC2680073.
- Zhu TC, Finlay JC. The role of photodynamic therapy (PDT) physics. Med Phys. 2008 Jul;35(7):3127-36. Review. PubMed PMID: 18697538; PubMed Central PMCID: PMC2673560.
- Li J, Zhu TC. Determination of in vivo light fluence distribution in a heterogeneous prostate during photodynamic therapy. Phys Med Biol. 2008 Apr 21;53(8):2103-14. doi: 10.1088/0031-9155/53/8/007. Epub 2008 Mar 27. PubMed PMID: 18369279; PubMed Central PMCID: PMC3276882.
- Finlay JC, Li J, Zhou X, and Zhu TC, “Patient-specific dosimetry for photodynamic therapy,” Proceedings of light-activated tissue regeneration and therapy conference, Waynant R and Tata DB (Eds) Springer, New York, NY, 2008: 115-125.
- Cengel, K.A. and Hahn, S.M., Photodynamic Therapy. Cancer: Principles and Practice of Oncology, 2008: p. 767-774.
- Sunar U, Makonnen S, Zhou C, Durduran T, Yu G, Wang HW, Lee WM, Yodh AG. Hemodynamic responses to antivascular therapy and ionizing radiation assessed by diffuse optical spectroscopies.Opt Express. 2007 Nov 12;15(23):15507-16. PubMed PMID: 19550836.
- Wang HW, Rickter E, Yuan M, Wileyto EP, Glatstein E, Yodh A, Busch TM. Effect of photosensitizer dose on fluence rate responses to photodynamic therapy. Photochem Photobiol. 2007 Sep-Oct;83(5):1040-8. PubMed PMID: 17880498.
- Wang HW, Finlay JC, Lee K, Zhu TC, Putt ME, Glatstein E, Koch CJ, Evans SM, Hahn SM, Busch TM, Yodh AG. Quantitative comparison of tissue oxygen and motexafin lutetium uptake by ex vivo and noninvasive in vivo techniques in patients with intraperitoneal carcinomatosis. J Biomed Opt. 2007 May-Jun;12(3):034023. PubMed PMID: 17614731.
- Cengel KA, Glatstein E, Hahn SM. Intraperitoneal photodynamic therapy. Cancer Treat Res. 2007;134:493-514. Review. PubMed PMID: 17633077.
- Ross HM, Smelstoys JA, Davis GJ, Kapatkin AS, Del Piero F, Reineke E, Wang H, Zhu TC, Busch TM, Yodh AG, Hahn SM. Photodynamic therapy with motexafin lutetium for rectal cancer: a preclinical model in the dog. J Surg Res. 2006 Oct;135(2):323-30. Epub 2006 May 2. PubMed PMID: 16650871.
- Hahn SM, Putt ME, Metz J, Shin DB, Rickter E, Menon C, Smith D, Glatstein E, Fraker DL, Busch TM.Photofrin uptake in the tumor and normal tissues of patients receiving intraperitoneal photodynamic therapy. Clin Cancer Res. 2006 Sep 15;12(18):5464-70. PubMed PMID: 17000681.
- Henderson BW, Busch TM, Snyder JW. Fluence rate as a modulator of PDT mechanisms. Lasers Surg Med. 2006 Jun;38(5):489-93. Review. PubMed PMID: 16615136.
- Busch TM. Local physiological changes during photodynamic therapy. Lasers Surg Med. 2006 Jun;38(5):494-9. Review. PubMed PMID: 16788920.
- Hahn SM, Fraker DL, Mick R, Metz J, Busch TM, Smith D, Zhu T, Rodriguez C, Dimofte A, Spitz F, Putt M, Rubin SC, Menon C, Wang HW, Shin D, Yodh A, Glatstein E. A phase II trial of intraperitoneal photodynamic therapy for patients with peritoneal carcinomatosis and sarcomatosis. Clin Cancer Res. 2006 Apr 15;12(8):2517-25. PubMed PMID: 16638861.
- Cengel KA, Hahn SM, Glatstein E. C225 and PDT combination therapy for ovarian cancer: the play's the thing. J Natl Cancer Inst. 2005 Oct 19;97(20):1488-9. PubMed PMID: 16234556.
- Li H, Marotta DE, Kim S, Busch TM, Wileyto EP, Zheng G. High payload delivery of optical imaging and photodynamic therapy agents to tumors using phthalocyanine-reconstituted low-density lipoprotein nanoparticles. J Biomed Opt. 2005 Jul-Aug;10(4):41203. Erratum in: J Biomed Opt. 2005 Nov-Dec;10(6):069801. PubMed PMID: 16178627.
- Yu G, Durduran T, Zhou C, Wang HW, Putt ME, Saunders HM, Sehgal CM, Glatstein E, Yodh AG, Busch TM. Noninvasive monitoring of murine tumor blood flow during and after photodynamic therapy provides early assessment of therapeutic efficacy. Clin Cancer Res. 2005 May 1;11(9):3543-52. PubMed PMID: 15867258.
- Busch TM, Hahn SM. Multidrug resistance in photodynamic therapy. Cancer Biol Ther. 2005 Feb;4(2):195-6. Epub 2005 Feb 28. PubMed PMID: 15738647.
- Wang HW, Zhu TC, Putt ME, Solonenko M, Metz J, Dimofte A, Miles J, Fraker DL, Glatstein E, Hahn SM, Yodh AG. Broadband reflectance measurements of light penetration, blood oxygenation, hemoglobin concentration, and drug concentration in human intraperitoneal tissues before and after photodynamic therapy. J Biomed Opt. 2005 Jan-Feb;10(1):14004. PubMed PMID: 15847585.
- Wang HW, Putt ME, Emanuele MJ, Shin DB, Glatstein E, Yodh AG, Busch TM. Treatment-induced changes in tumor oxygenation predict photodynamic therapy outcome. Cancer Res. 2004 Oct 15;64(20):7553-61. PubMed PMID: 15492282.
- Busch TM, Hahn SM, Wileyto EP, Koch CJ, Fraker DL, Zhang P, Putt M, Gleason K, Shin DB, Emanuele MJ, Jenkins K, Glatstein E, Evans SM. Hypoxia and Photofrin uptake in the intraperitoneal carcinomatosis and sarcomatosis of photodynamic therapy patients. Clin Cancer Res. 2004 Jul 15;10(14):4630-8. PubMed PMID: 15269134.
- Friedberg JS, Mick R, Stevenson JP, Zhu T, Busch TM, Shin D, Smith D, Culligan M, Dimofte A, Glatstein E, Hahn SM. Phase II trial of pleural photodynamic therapy and surgery for patients with non-small-cell lung cancer with pleural spread. J Clin Oncol. 2004 Jun 1;22(11):2192-201. PubMed PMID: 15169808.
- Wilson JJ, Jones H, Burock M, Smith D, Fraker DL, Metz J, Glatstein E, Hahn SM. Patterns of recurrence in patients treated with photodynamic therapy for intraperitoneal carcinomatosis and sarcomatosis. Int J Oncol. 2004 Mar;24(3):711-7. PubMed PMID: 14767557.
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