Clinical Research Head and Neck Cancers

Strategic Direction and Overarching Themes for the Service

(section under construction)

Description of Programs and Protocols within the Service

Principal Investigator: Alexander Lin, M.D.
Coordinator: 
Office: 
UPCC#: 15313

This is a single arm, phase II study of nelfinavir (1250 mg given po bid) and concurrent chemoradiotherapy in locally advanced head and neck cancer. Locoregional control will be compared to published historical results. There will be a total of 28 patients enrolled on the study.

Principal Investigator: Alexander Lin, M.D.
Coordinator: 
Office: 
UPCC#: 18316

The overall goal of this trial is to identify a less toxic approach to the delivery of conformal radiation therapy for patients with cancers of the oropharynx. We aim to show that Intensity Modulated Proton Therapy (IMPT) will substantially reduce the burden of acute and late toxicity, result in faster recovery and return to function, with similar rates of long-term survivorship, compared with radiation using Intensity Modulated Photon Therapy (IMRT).

Principal Investigator: John Nicholas Lukens, M.D. 
Coordinator:
Office: 
UPCC#: 15318

This is a single-arm Phase II study of adjuvant radiation for locally advanced p16+ oropharyngeal squamous cell carcinoma. The main purpose of this research is to determine the likelihood of cancer growing back in the throat or in the neck two years after completion of radiation if lower doses of radiation are used to a smaller area of the head and neck region than is currently used in standard of care

Publications from the Service Members