Department of Radiation Oncology

Koumenis Lab

Koumenis Lab - Summer 2019

CURRENT LAB MEMBERS

Richard H. Chamberlain Professor, Vice-Chair, Director of RadOnc Research 
Senior Research Investigator:
Research Associate
Postdoctoral Fellows
Lab Manager
Graduate Students:
Undergraduate Students:
Rotation Project Students:
  • Currently the lab is accepting 2 new rotation students.

 

FORMER STUDENTS

Former Graduate Students:     

  • Feven Tameire, PhD (Cancer Biology)
    Current Position: Scientist, HiberCell
  • Lauren Brady, PhD (Genetics and Gene regulation)
    Current Position: Scientist, Oncology research group, Janssen Research & Development
  • Natalie Daurio, Ph.D. (Pharmacology)
    Current Position: Scientist, Pfizer
  • Stacey Lehman, Ph.D. (Cancer Biology)
    Current Position: Postdoctoral Fellow, National Cancer Institute
  • Carly Sayers, Ph.D. (Pharmacology)
    Current Position: Postdoctoral Fellow, National Institute of Health, Intramural Research Program
  • David Guttman M.S., M.D., 2011-2013
    Current Position: Radiation Oncologist, Memorial Sloan Kettering
  • Lauren Hertan, M.S., M.D., 2008-2010
    Current position: Radiation Oncologist, Beth Israel Deaconess Medical Center
  • Jiangbin Ye, Ph.D., UPenn, 2004-2009
    Current position: Assistant Professor of Radiation Oncology, Stanford University
  • Prashanthi Javvadi, Ph.D., UPenn, 2004-2009
    Current position: Postdoctoral Fellow, UT Southwestern Medical Center, TX
  • Lori Hart, Ph.D., Wake Forest Univ. 2002-2006
    Current position: Senior Medical Writer, ETHOS Health Communications

Former Postdoctoral Fellows:

  • Souvik Dey, PhD
    Current position: Research Assistant Professor, Thomas Jefferson University
  • Vladimir Popov, Ph.D.
    Current position: Business Development Manager, Leidos Biomedical Research, Inc.
  • Lori Hart, Ph.D.
    Current position: Senior Medical Writer, ETHOS Health Communications
  • Kevin Du, M.D., Ph.D.
    Current Position: Associate Professor, NYU Langone Medical Center
  • Haiyan Zhang, Ph.D. 2008-2009
    Current position: Vice President, Senior Quantitative Analyst, BNY Mellon
  • Meixia Bi, M.D. 2002-2008
    Current position: Research Scientist, GlaxoSmithKline, Phoenixville, PA
  • Brian Lally, M.D. Translational Radiation Oncology Fellow, 2004-2006
    Current position: Clinician of Radiation Oncology, Penn Medicine

Former Lab Members:

  • Tatini Datta, B.A.      
    Current Position: Medical Student, Univ. Nevada, Reno
  • Monika Kumanova, M.D.      
    Current postion: Physician, Penn Medicine
  • Diane Marotta, Ph.D.            
    Former Research Associate            
    Current Position: Instructor, University of Pennsylvania, Department of Radiology
  • Johann Kolev, Summer 2009            
    Former Summer Rotating Undergraduate Student             
    Current Position: Undergraduate, University of Florida
  • Kelly Sloane, B.S., 2008-2009            
    Former Research Specialist/Lab Manager             
    Current Position: Medical Resident, Johns Hopkins University School of Medicine
  • Christine (Naczki) McMahan            
    Former Research Assistant/Lab Manager         
    Current Position: Senior Research Assistant, Department of Radiation Oncology, WFUSM
  • Brett Bell, B.S.
    Former Undergraduate Lab Member
    Current Position: Medical Student, Albert Einstein College of Medicine
  • Carlo Salas, B.A.
    Former Undergraduate Lab Member

SELECTED PUBLICATIONS

Tameire Feven, Verginadis Ioannis I, Leli Nektaria Maria, Polte Christine, Conn Crystal S, Ojha Rani, Salas Salinas Carlo, Chinga Frank, Monroy Alexandra M, Fu Weixuan, Wang Paul, Kossenkov Andrew, Ye Jiangbin, Amaravadi Ravi K, Ignatova Zoya, Fuchs Serge Y, Diehl J Alan, Ruggero Davide, Koumenis Constantinos: ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumour progression. Nat Cell Bio 21(7): 889-899, Jul 2019.

Bell BI, Koduri S, Salas Salinas C, Monslow J, Puré E, Ben-Josef E, Koumenis C, Verginadis II: Interleukin 6 Signaling Blockade Exacerbates Acute and Late Injury From Focal Intestinal Irradiation. Int J Radiat Oncol Biol Phys 103(3): 719-727, Mar 2019.

An Interferon-Driven Oxysterol-Based Defense against Tumor-Derived Extracellular Vesicles. Ortiz A, Gui J, Zahedi F, Yu P, Cho C, Bhattacharya S, Carbone CJ, Yu Q, Katlinski KV, Katlinskaya YV, Handa S, Haas V, Volk SW, Brice AK, Wals K, Matheson NJ, Antrobus R, Ludwig S, Whiteside TL, Sander C, Tarhini AA, Kirkwood JM, Lehner PJ, Guo W, Rui H, Minn AJ, Koumenis C, Diehl JA, Fuchs SY: An Interferon-Driven Oxysterol-Based Defense against Tumor-Derived Extracellular Vesicles. Cancer Cell 35(1): 33-45, Jan 2019.

Ojha R, Leli NM, Onorati A, Piao S, Verginadis II, Tameire F, Rebecca VW, Chude CI, Murugan S, Fennelly C, Noguera-Ortega E, Liu S, Xu X, Krepler C, Xiao M, Xu W, Wei Z, Frederick DT, Boland G, Mitchell TC, Karakousis GC, Schuchter LM, Flaherty KT, Zhang G, Herlyn M, Koumenis C, Amaravadi RK.: ER Translocation of the MAPK Pathway Drives Therapy Resistance in BRAF-Mutant Melanoma. Cancer Discov 9(3): 396-415, Dec 2018.

Baumann BC, Verginadis II, Zeng C, Bell B, Koduri S, Vachani C, MacArthur KM, Solberg TD, Koumenis C, Metz JM: Assessing the Validity of Clinician Advice That Patients Avoid Use of Topical Agents Before Daily Radiotherapy Treatments. JAMA Oncol 4(12): 1742-1748, Dec 2018.

Bi Y, Verginadis II, Dey S, Lin L, Guo L, Zheng Y, Koumenis C.: Radiosensitization by the PARP inhibitor olaparib in BRCA1-proficient and deficient high-grade serous ovarian carcinomas. Gynecol Oncol 150(3): 534-544, Sep 2018.

Walton ZE, Patel CH, Brooks RC, Yu Y, Ibrahim-Hashim A, Riddle M, Porcu A, Jiang T, Ecker BL, Tameire F, Koumenis C, Weeraratna AT, Welsh DK, Gillies R, Alwine JC, Zhang L, Powell JD, Dang CV: Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR. Cell 174(1): 72-87, Jun 2018.

Nguyen HG, Conn CS, Kye Y, Xue L, Forester CM, Cowan JE, Hsieh AC, Cunningham JT, Truillet C, Tameire F, Evans MJ, Evans CP, Yang JC, Hann B, Koumenis C, Walter P, Carroll PR, Ruggero D: Development of a stress response therapy targeting aggressive prostate cancer. Sci Transl Med 10(439), May 2 2018.

Wang Y, Xu H, Liu T, Huang M, Butter PP, Li C, Zhang L, Kao GD, Gong Y, Maity A, Koumenis C, Fan Y: Temporal DNA-PK activation drives genomic instability and therapy resistance in glioma stem cells. JCI Insight 3(3), Feb 8 2018.

Bu Y, Yoshida A, Chitnis N, Altman BJ, Tameire F, Oran A, Gennaro V, Armeson KE, McMahon SB, Wertheim GB, Dang CV, Ruggero D, Koumenis C, Fuchs SY, Diehl JA: A PERK-miR-211 axis suppresses circadian regulators and protein synthesis to promote cancer cell survival. Nat Cell Bio 20(1): 104-115, Jan 2018.

Brady LK, Wang H, Radens CM, Bi Y, Radovich M, Maity A, Ivan C, Ivan M, Barash Y, Koumenis C: Transcriptome analysis of hypoxic cancer cells uncovers intron retention in EIF2B5 as a mechanism to inhibit translation. PLoS Biol 15(9): e2002623, Sep 29 2017.

 

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