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Theresa M.Busch, Ph.D.
Assistant Professor

Theresa Busch
buschtm@mail.med.upenn.edu
INSTITUTION AND LOCATION

DEGREE
YEAR
CONFERRED
FIELD
OF STUDY

University of Scranton, Scranton, PA

B.S.

1993

Biophysics

State University of New York at Buffalo, Roswell Park Cancer Institute Division, Buffalo, NY

Ph.D.

1998

Biophysics
PROFESSIONAL POSITIONS:

1993-1998

Research Affiliate, Department of Radiation Biology, Roswell Park Cancer Institute, Buffalo, NY
 

2001

Adjunct Professor of Biology (fall semester),
St. Joseph’s University, Philadelphia, PA

 

1998-2001

Postdoctoral Researcher, Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA
 

2001

Assistant Professor, Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA
 
 
AWARDS AND HONORS:

1993

Professor Joseph P. Harper Award for Excellence in Physics, University of Scranton

1993-1994

Roswell Park Cancer Institute, Bertha Scott Endowed Fellowship

1996, 1999

Travel award for abstract presentation, American Society for Photobiology (ASP)

1996

First Place, Roswell Park Graduate Research Forum

2000

Travel award for abstract presentation, International Conference on Photobiology/ASP

2001

Lubbers Award, The International Society on Oxygen Transport to Tissue

2002-2003

Ad hoc member of a special meeting of Radiation Study Section (Feb. 2002, March 2002, Nov. 2003); Member of Special Study Section (Nov. 2002, March 2003, June 2003)
SELECTED PUBLICATIONS (1998 - present):

  1. Sitnik TM, Hampton JA and Henderson BW: Reduction of tumor oxygenation during and after photodynamic therapy in vivo: effects of fluence rate. B.J. Cancer 77: 1386-1394, 1998.

  2. Sitnik TM and Henderson BW: The effect of fluence rate on tumor and normal tissue responses to photodynamic therapy. Photochem. Photobiol. 67: 462-466, 1998.

  3. Henderson BW, Sitnik-Busch TM and Vaughan LA: Potentiation of PDT anti-tumor activity in mice by nitric oxide synthase inhibition is fluence rate dependent. Photochem. Photobiol. 70(1) 64-71, 1999.

  4. Henderson BW, Busch TM, Vaughan LA, Frawley NP, Babich D, Sosa TA, Zollo JD, Dee AS, Cooper MT, Bellnier DA, Greco WR and Oseroff AR: Photofrin photodynamic therapy can significantly deplete or preserve oxygenation in human basal cell carcinomas during treatment, depending on fluence rate. Cancer Res. 60: 525-529, 2000.

  5. Busch TM, Hahn SM, Glatstein EJ, Evans SM and Koch CJ: Depletion of tumor oxygenation during photodynamic therapy: detection by the hypoxic marker EF3 [2-(2-nitroimidazol-1(H)-yl)-N-(3,3,3,-trifluoropropyl)acetamide]. Cancer Res. 60: 2636-2642, 2000.

  6. Griffin GM, Zhu T, Solonenko M, DelPiero F, Kapatkin A, Busch TM, Yodh A, Polin G, Bauer T, Fraker D, and Hahn SM: Preclinical evaluation of motexafin lutetium-mediated intraperitoneal photodynamic therapy in a canine model. Clin. Cancer Res. 7:374-381, 2001.

  7. Menon C, Kutney SN, Lehr SC, Hendren SK, Busch TM, Hahn SH, Fraker DL: Vascularity and uptake of photosensitizer in small human tumor nodules: implications for intraperitoneal photodynamic therapy. Clin. Cancer Res. 7:3904-3911, 2001.

  8. Solonenko M, Cheung R, Busch TM, Kachur A, Griffin GM, Vulcan T, Zhu T, Wang H, Hahn S, Yodh AG: In vivo reflectance measurement of optical properties, blood oxygenation, and motexafin lutetium in canine large bowls, kidneys, and prostates. Phys. Med. Biol. 47(6):857-73, 2002.

  9. Busch TM, Wileyto EP, Emanuele MJ, Del Piero F, Marconat, L, Glatstein E, Koch CJ. Photodynamic therapy creates fluence rate dependent gradients in the intra-tumoral spatial distribution of oxygen, Cancer Res. 62:, 7273-7279, 2002.

  10. Busch TM, Wileyto EP, Evans SM, Koch CJ. Quantitative spatial analysis of hypoxia and vascular perfusion in tumor sections. Advances in Experimental Medicine & Biology 510:37-43, 2003.

  11. Cheung R, Solonenko M, Busch TM, Del Piero F, Putt M, Hahn SM, Yodh AG. Correlation of in vivo photosensitizer fluorescence and photodynamic therapy-induced depth of necrosis in a murine tumor model. Journal of Biomedical Optics 8(2):248-252, 2003.

  12. Zhang M, Zhang Z, Blessington D, Li H, Busch TM, Madrak V, Miles J, Chance B, Glickson JD, Zheng G. Pyropheophorbide 2-deoxyglucosamide: A new photosensitizer targeting glucose transporters. Bioconjugate Chemistry 14(4):709-14, 2003.

  13. Yom SS, Busch TM, Friedberg JS, Wileyto EP, Smith D, Glatstein E, Hahn SM. Elevated serum cytokine levels in mesothelioma patients treated with pleurectomy or extrapleural pneumonectomy and adjuvant intraoperative photodynamic therapy. Photochem. Photobiol. 78(1):75-81, 2003.

  14. Henderson BW, Gollnick SO, Snyder JW, Busch TM, Kousis PC, Cheney RT, Morgan J. Choice of oxygen-conserving treatment regimen determines the inflammatory response and outcome of photodynamic therapy of tumors. Cancer Res. 64(6):2120-6, 2004.

  15. Busch TM, Hahn SM, Wileyto EP, Koch CJ, Fraker DL, Zhang P, Putt M, Gleason K, Shin DB, Emanuele MJ, Jenkins K, Glatstein E, Evans SM. Hypoxia and Photofrin uptake in the intraperitoneal carcinomatosis and sarcomatosis of photodynamic therapy patients. Clin. Cancer Res. 10: 4630–4638, 2004.

  16. Busch TM and Hahn SM. Photodynamic Therapy. In: Abeloff, Armitage, Neiderhuber, Kastan, and McKenna (eds.), Clinical Oncology. Philadelphia: P. M. Gorden Associates, 639-660, 2004.

  17. Wang H-W, Putt ME, Emanuele MJ, Shin DB, Glatstein E, Yodh AG, Busch TM. Treatment-induced changes in tumor oxygenation predict photodynamic therapy outcome. Cancer Res. 64(20):7553-7561, 2004.

  18. Zhang Z, Blessington D, Li H, Busch TM, Glickson J, Luo Q, Chance B, Zheng G. Redox ratio of mitochondria as an indicator for the response of photodynamic therapy. Journal of Biomedical Optics 9(4):772-8, 2004.

  19. Zhu TC, Dimofte A, Finlay JC, Stripp D, Busch T, Miles J, Whittington R, Malkowicz SB, Tochner Z, Glatstein E, Hahn SM. Optical properties of human prostate at 732 nm measured in mediated photodynamic therapy. Photochem. Photobiol. 81(1):96-105, 2005.

  20. Busch TM, Hahn SM. Multidrug resistance in photodynamic therapy. Cancer Biology & Therapy 4(2): 195-6, 2005.

  21. Yu G, Durduran T, Zhou C, Wang HW, Putt ME, Saunders M, Sehgal CM, Glatstein E, Yodh AG, Busch TM. Noninvasive monitoring of murine tumor blood flow during photodynamic therapy provides early assessment of treatment efficacy. Clin. Cancer Res. 11:3543-52, 2005

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