Stephen M. Hahn, M.D.
Henry K. Pancoast Professor

Chairman of the Department of Radiation Oncology

Education

• B.A., Rice University (Biology), 1980
• M.D., Temple University School of Medicine, 1984
• Internship and Residency, Internal Medicine, University of California, San Francisco Hospitals, 1984-1987
• Chief Resident, Internal Medicine University of California, San Francisco Hospitals, 1987-1988
• Medical Oncology Fellowship, Medicine Branch National Cancer Institute, Bethesda, MD, 1988-1991
• Residency, Radiation Oncology National Cancer Institute, Bethesda, MD, 1991-1994

Board Certifications

• American Board of Internal Medicine (Internal Medicine) 1987
• American Board of Internal Medicine (Medical Oncology) 1999, 2002
• American board of Radiology (Radiation Oncology) 1995

Areas of Interest

Clinical:

Dr. Hahn is board certified in Medical Oncology and Radiation Oncology.  His clinical interests include combined modality therapies for cancer, as well as the treatment of lung cancer, sarcoma, and prostate cancer. 

Research:

Dr. Hahn’s research interests include 1) the combination of molecularly-targeted therapies with radiation therapy especially as they relate to abnormal signal transduction pathways in cancers.  2) the development of photodynamic therapy for the treatment of serosal malignancies and prostate cancer, 3) the evaluation of hypoxia in human tumors, and 4) the development of imaging techniques of the tumor microenvironment.

Publications

Hahn, S.M., Bernhard, E.J., Regine, W., Mohiuddin, M., Haller, D.G., Stevenson, J.P., Smith, D., Pramanik, B., Tepper, J., DeLaney, T.F., Kiel, K.D., Morrison, B., Deutsch, P., Muschel, R.J., and McKenna, W.G.  A Phase I Trial of the Fanresyltransferase Inhibitor L-778,123 and Radiotherapy for locally advanced lung and head & neck cancer.  Clin Cancer Res, 8:1065-1072, 2002.

Freidberg, J.S., Mick, R., Stevenson, J., Metz, J., Zhu, T., Buyske, J., Sterman, D., Pass, H., Glatstein, E., and Hahn, S.M.  A Phase I Study of Foscan-mediated Photodynamic Therapy and Surgery in patients with mesothelioma.  Ann Thorac Surg. 75:952-959, 2003.

Colevas, A.D., Brown, J.M., Hahn, S., Mitchell, J., Camphausen, K., Coleman, C.N. for the National Cancer Institute Radiation Modifier Working Group.  Development of investigational Radiation Modifiers.  J Natl Cancer Inst 95(9):  646-651, 2003.

Friedberg, J.S., Mick, R., Stevenson, J.P., Zhu, T., Busch, T.M., Shin, D., Smith, D., Culligan, M., Dimofte, A., Glatstein, E., and Hahn, S.M.  A Phase II Trial of Pleural Photodynamic Therapy (PDT) in patients with Non-small cell Lung Cancer (NSCLC) with Pleural Spread.  J Clin Onc, 22:2192-2201, 2004.

Busch, T.M., Hahn, S.M., Wileyto, E.P., Koch, C.J., Fraker, D.L., Zhang, P., Putt, M., Gleason, K., Shin, D.B., Emanuele, M.J., Jenkins, K., Glatstein, E., and Evans, S.M.  Hypoxia and Photofrin Uptake in the Intraperitoneal Carcinomatosis and Sarcomatosis of Photodynamic therapy Patients.  Clin Cancer Res 10:4630-4638, 2004.

Evans, S.M., Judy, K.D., Dunphy, I., Jenkins, W.T., Nelson, P.T., Collins, R., Wileyto, E.P., Jenkins, K., Hahn, S.M., Stevens, C.W., Judkins, A.R., Phillips, P., Geoerger, B., Koch, C.J.  Comparative measurements of hypoxia in human brain tumors using needle lectrodes and EF5 binding.  Cancer Res 64:1886-1892, 2004.

Martin, N.E., Brunner, T.B., Kiel, K.D., DeLaney, T.F., Regine, W.F., Mohiuddin, M., Rosato, E.F., Haller, D.G., Stevenson, J.P., Smith, D.,, Pramanik, B., Tepper, J., Tanaka, W.K., Morrison, B., Deutsch, P., Gupta, A.K., Muschel, R.J., McKenna, W.G., Bernhard, E.J., and Hahn, S.M.  A Phase I Trial of the Dual Farnesyltransferase and Geranylgeranyltransferase Inhibitor L-778,123 and Radiotherapy for Locally Advanced Pancreatic Cancer.  Clin Cancer Res 10:5447-5454, 2004.

Metz, J.M., Smith, D., Mick, R., Lustig, R., Mitchell, J., Cherakuri, M., Glatstein, E., and Hahn, S.M.  A Phase I Study of Topical Tempol for Prevention of Alopecia Induced by Whole Brain Radiotherapy.  Clin Cancer Res 10:6411-6417, 2004.

Wang, H-W., Zhu, T. C., Putt, M.E., Solonenko, M., Metz, J., Dimofte, A., Miles, J., Fraker, D.L, Glatstein, E., Hahn, S.M., and Yodh, A.G.  Broadband reflectance measurements of light penetration, blood oxygenation, hemoglobin concentration, and drug concentration in human intraperitoneal tumors before and after photodynam ic therapy.  J Biomed Optics 2005, In press, 2005.

Zhu, T.C., Finlay, J.C., and Hahn, S.M.  Determination of the distribution of light, optical properties, drug concentration, and tissue oxygenation in-vivo in human prostate during motexafin lutetium-mediated photodynamic therapy.  J. Photochem Photobiol B.  In press, 2005.

 

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