Research Updates

Winter/Spring

RadOnc would like to welcome Ioannis Verginadis, MSc, PhD to the department in his new role as Research Assistant Professor! 

Congratulations to Duo Zhang of the Fan lab on a successful dissertation defense!

We welcome Chris Heer to the division as the new Financial Administrative Coordinator. 

Summer/Fall

• Congrats to Kyle Kim will now be a Research Specialist A and is joining the Verginadis Lab.
• Congratulations to Ioannis Verginadis for receiving the Abramson Cancer Center’s ACS pilot grant!
• Congratulations to Priyanka Chowdhury from the Koumenis Lab for receiving an RRS Travel Award!
• RadOnc would like to welcome Shiva Shahrampour, PhD is our new Technical Director of CARC.
• Welcome Nektarios Kostopoulos, Postdoctoral Researcher to the Koumenis lab and congratulations for successfully defending his thesis on 9/8/2023, titled “Radiation-Driven Cross Presentation and STING Activation Enhance CAR T Cell Therapy in a Murine Lymphoma Model”
• Welcome Shawnaleh Cada, Research Specialist to the Koumenis Lab
• Congratulations to Dr. Ioannis Verginadis for receiving the Best Abstract Award, titled: EARLY INFLAMMATION AND INTERFERON SIGNALING COORDINATE ENHANCED INTESTINAL CRYPT REGENERATION AFTER WHOLE ABDOMEN FLASH PROTON RADIOTHERAPY,  at the 2023 FRPT Conference. 

Spring

Congratulations to Menggui Huang, PhD, recipient of the Outstanding Poster Award given by The North American Vascular Biology Organization's annual conference. 

Congratulations to Dr. Christoforos Thomas who accepted a Research Assistant Professorship with The University of Houston beginning in February. 

Congratulations to Dr. Amit Maity who accepted a Chairmanship with the University of Utah Spencer Fox Eccles School of Medicine and the Huntsman Center beginning in June. 

News Flash: Constantinos Koumenis, PhD, the Richard H. Chamberlain Professor of Research Oncology, spoke about Penn Medicine recently being awarded a $12.3M NIH Grant to study ultra-fast, high-dose FLASH radiation therapy for cancer. Listen to the podcast here

Fall

Congratulations to Ioannis Verginadis, PhD, Adjunct Assistant Professor, Department of Radiation Oncology for receiving the 2 below awards!

• Early Career Investigator (ECI) Travel Award at the Annual Meeting of the Radiation Research Society (RRS)
• Best Abstract Award at the Flash Radiotherapy and Particle Therapy Conference (FRPT)

Winter/ Spring

Research has 2 Transdisciplinary Awards Program in Translational Medicine and Therapeutics from ITMAT awards to celebrate:
Ioannis Verginadis, PhD, PI on Pre-clinical studies on Proton FLASH Radiotherapy for treatment of orthotopic pancreatic tumors and sparing normal intestine tissues, a 2 year award of $150K
Yi Fan, PI on Novel nano-vasculotherapy to improve glioblastoma immunotherapy, a 2 year award of $150K

A big congratulations to Ioannis Verginadis, PhD, Senior Research Investigator in Koumenis Lab for receiving the "Best Oral Presentation Award" at the 2021 Flash Radiotherapy & Particle Therapy Conference for his presentation, Preclinical Studies with Proton FLASH Radiotherapy: Biological Effects and Potential Mechanisms

The division would like to recognize the following promotions:

• Keith Cengel, MD, PhD, Professor of Radiation Oncology in the Standing Faculty - Clinician Educator track
• Andy J. Minn, MD, PhD, Professor of Radiation Oncology and Director of the Mark Foundation Center at Penn

Winter/Spring: 

It is with great enthusiasm that we welcome Crystal Conn, PhD as Assistant Professor-Tenure Track, to the Research Division of Radiation Oncology!
Dr. Conn started with us on Thursday, January 2, 2020. She most recently was a Postdoctoral Fellow at UCSF in the lab of Dr. Davide Ruggero, one of the premier groups internationally engaged in the study of translational control of gene expression in cancer. Dr. Conn’s research interests are centered on understanding the identifying adaptive stress responses that are translationally regulated, primarily in lung and prostate cancer, allowing for early detection of malignant disease with potential for new therapeutic applications. Her expertise in the salient features in translational control of gene expression, which is increasingly being appreciated as a major contributor to malignancies and immune system function, will enable her to interface with multiple groups within the RadOnc department, as well as the School of Medicine and beyond.

We would like to recognize Alexi Dreyfuss from the Koumenis Lab on graduating with her MD/ MTR. She defended her MTR Thesis based on work in the Koumenis lab. 

Summer/Fall:

Please join us in congratulating Theresa Busch, PhD on her appointment as the Radiation Oncology Department’s first Vice Chair for Inclusion, Diversity and Equity. This new role will both report to and work closely with the Department Chair to oversee, promote, and facilitate excellence in diversity, inclusion, equity and anti-racism efforts across all aspects of the department. The Vice Chair is responsible for creating and maintaining a culture that embraces inclusion and ensuring that all departmental policies and practices are grounded in the tenants of equity and anti-racism. Together with departmental leadership, the Vice Chair will examine our research, clinical and educational activities through the lens of diversity, equity and inclusion, and develop strategies to build a strong culture of anti-racism as well as metrics to measure the success of these strategies.

Congratulations to Ioannis Verginadis, Senior Research Investigator, on winning the Career Development Award from the Radiation Research Foundation on the project entitled “Delineating the role of STAT3 on normal tissue radioprotection and pancreatic tumor radiosensitization in a preclinical setting ”. This proposal is based on data generated in the past 2 years regarding the effects of focal radiotherapy on intestinal damage. Together with Dr. Constantinos Koumenis and Dr. Edgar Ben-Josef, Ioannis developed a novel, more clinically relevant mouse model of intestinal radiation injury based on precision, image-guided radiotherapy using the Small Animal Radiation Research Platform (SARRP). This model gives us the unique capability to fully mimic the clinical setting because we can study both irradiation(IR)-induced damage to the normal intestine and the impact of IR on orthotopic pancreatic tumor models in the same mice. The goal of this effort is to translate the findings into human clinical trials for early detection and therapeutic intervention of radiotherapy(RT)-induced intestinal toxicity. If the results are promising, Dr. Ben-Josef will initiate a clinical trial using the STAT3 inhibitor OPB-51602 combined with RT as a novel treatment for pancreatic tumors.

Congratulations to Dr. Gary Kao and Dr. Jay Dorsey for their participation in the paper entitled “Multi-block Discriminant Analysis of Integrative 18F-FDG-PET/CT Radiomics for Predicting Circulating Tumor Cells in Early Stage Non-small Cell Lung Cancer Treated with Stereotactic Body Radiation Therapy”, which was an Award Winner at the Science Council Session of the 2020 American Association of Physicists in Medicine (AAPM). Authors of the paper: Sang Ho Lee, PhD, Gary D. Kao, MD, PhD, Steven J. Feigenberg, MD, Jay F. Dorsey, MD, PhD, Melissa A. Frick, MD, Samuel Jean-Baptiste, MD, Chibueze Z. Uche, PhD, Yong Fan, PhD, Ying Xiao, PhD

The division would like to recognize the following promotions: 

• Meena Swaminathan, Director of Fiscal Operations
• Christie Foti, Payroll and Onboarding Manager
• Jenine Iannaccone, Grants Manager B
• Yi Fan, MD, PhD, Associate Professor of Radiation Oncology in the Standing Faculty
• Andy Minn, MD, PhD, Professor of Radiation Oncology in the Standing Faculty

Please join us in congratulating Dr. Yi Fan, along with Fan Lab in publishing the paper, Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2α, in the prestigious Nature Communications.

Congratulations to Dr. Yi Fan – the 2018 Springer Junior Investigator Award Recipient! He was awarded at the Vascular Biology 2018, where he presented his Springer Award lecture, "Wnt-mediated endothelial transformation into mesenchymal stem cell-like cells induces chemoresistance in glioblastoma" 

June 

Congratulations to Dr. Yi Fan for recently receiving the following two awards: the Sharpe Award from National Brain Tumor Society (NBTS) and the Early Career Investigator Award from the Radiation Research Society (RRS).

May 

Congratulations to Dr. Andrea Facciabene! He received an award at the Penn Center for Innovation Celebration for Innovation, held on May 3, 2017. Dr. Facciabene was honored for two US patents (# 9,289,426 and #9,290,556).  Respectively, these inventions involve Methods and compositions for treating solid tumors and enhancing tumor vaccines and Tumor vascular marker-targeted vaccines.

February 

Congratulations to all who received the Radiation Oncology Translational Center of Excellence (TCE) pilot awards!

1. Using Radiation and Blockade of Interferon Signaling to Improve Durable Response to Immune Checkpoint Blockade Co-PIs: Andy Minn, MD, PhD (RadOnc) & Taku Kambayashi, MD, PhD, (Pathology and Laboratory Medicine) Co-I: E. John Wherry, PhD (Microbiology)
2. PD-1 Blockade to Attenuate Surgery-Induced Immunosuppression during Intraoperative Photodynamic Therapy Co-PIs: Theresa Busch, PhD & Edmund Moon, MD (Medicine), Keith Cengel, MD, PhD Co-Is: Andrea Facciabene, PhD (RadOnc), Mary Putt, PhD, (Biostatistics and Epidemiology) & Sunil Singhal, MD (Surgery)
3. Hypofractionated radiotherapy as a vaccine in combination with the TLR7/8 agonist resiquimod for metastatic melanoma Co-PIs: Amit Maity, MD, PhD (RadOnc),  George Xu, MD, PhD (Pathology and Laboratory Medicine), & Alain Rook, MD (Dermatology) Co-I: Andrea Facciabene, PhD (RadOnc)

The research division congratulates Dr. Theresa Busch and Dr. Zhiliang Cheng (Bioengineering) labs’ for their proposal entitled Mesothelin-targeted nanophotosensitizer for photodynamic therapy of TNBC selected by the Center for Targeted Therapeutics and Translational Nanomedicine (CT3N) for funding.

We also congratulate Natalie Daurio in Koumenis Lab for a successful doctoral dissertation defense on March 28, 2016. The title of her thesis was “Tamoxifen Mediated Metabolic Stress: Molecular Mechanism and Therapeutic Opportunities.”.

Congratulations to Dr. Gary Kao on the award of his R01 grant, Circulating Tumor Cells Analyses and Molecular Profiling for Patients Receiving Radiation Therapy, which was recently funded by the National Cancer Institute.

We also congratulate Dr. Stephen Avery on receiving R21 grant, Protoacoustics - Clinical Based Range Verification for Cancer Treatment. This project was funded by the National Institute of Biomedical Imaging and Bioengineering.

Congratulations to Dr. Yi Fan was recently honored as a recipient of the 2016 American Association for Cancer Research (AACR) Judah Folkman Career Development Award for Angiogenesis Research. Dr. Fan was selected for this award based on the relevance of his research to the AACR’s mission and its expected impact in the field of cancer research.   This award recognizes Dr. Fan’s position as a burgeoning leader in cancer research.

The 2016 SUPERS program came to a close on Wednesday, August 3 with the end-of-the-program retreat where each of the fourteen SUPERS students presented a summary of their own hypothesis-driven research project.  Student projects included research in molecular radiobiology, photodynamic therapy, proton dosimetry and nuclear medicine and PET imaging.  In addition to their own hands-on lab experience, students took part in lectures and research discussions led by many of our faculty, as well as faculty from the departments of Radiology and Bioengineering. As the keynote speaker for the event, Dr. Michelle Alonso-Basanta from Penn Radiation Oncology described how her experiences as an undergraduate piqued her interest in a career as a clinician scientist. 2016 represented the 7^th summer for the SUPERS program, to date SUPERS has graduated 80 alumni and the vast majority, nearly 90%, have gone on to graduate and/or medical school.

2016 SUPERS students pictured with Dr. Eve Higginbotham, Vice Dean for Inclusion and Diversity at the Perelman School of Medicine. Dr. Higginbotham shared her own formative experiences as an undergrad while stressing the importance of diversity and inclusion to the future of research and medicine in the biomedical research community.

PDT: It's Not Just For People! - Check out this link for a story on how photodynamic therapy was recently used to treat Anita the horse for squamous cell cancer that surrounded both of her eyes.  Photodynamic therapy, or PDT as it is frequently called,  utilizes a light-sensitize drug and lasers to kill cancer cells.  Anita’s treatment was possible through the collaborative effort of Penn Medicine's Radiation Oncology and Penn Vet’s Large Animal Ophthalmology. PDT is studied for treating cancer in people by Radiation Oncology physicians, physicists, and scientists through a multidisciplinary grant that is funded by the National Institutes of Health.  It is currently under investigation through the Abramson Cancer Center for the treatment of malignant pleural mesothelioma in conjunction with surgery.

The Research Division congratulates Dr. Cameron Koch on receiving the Outstanding Research Award along with the late Dr. James Raleigh of University of North Carolina at Chapel Hill. This award was presented by Members of the Tumor Microenvironment Research Community at the 14th International Tumor Microenvironment Workshop in Vancouver, British Columbia. It is in recognition of Dr. Koch’s contributions to the identification, characterization and targeting of the tumor microenvironment for the advancement of cancer therapy and patient care.

We congratulate Dr. Andy Minn as the recipient of the 2015 Scientific Research Award presented by the American Cancer Society in honor of his outstanding leadership and accomplishments among local cancer professionals.

Additionally, congratulations are in order for Dr. Yi Fan on receiving the McCabe Award from the Perlman School of Medicine for his work on targeting endothelial plasticity to treat brain tumors. 

At the recent departmental retreat, Drs. Minn and Fan were further recognized for their achievements through awards for the Radiation Oncology Innovation Award and the Radiation Oncology Young Investigator Award of Excellence, respectively. The Innovation Award was presented to Dr. Minn in recognition of his novel and creative contributions to the field of Radiation Oncology. Dr. Fan received the Young Investigator Award of Excellence as a new faculty member in department (< 3 years) who has shown exemplary performance in the area of clinical service, research or teaching.

Congratulations to Drs. Jay Dorsey and Yi Fan who individually received grants on NeuroOncology Innovation from the Neuro Translational Center of Excellence of the Abramson Cancer Center.  Dr. Dorsey is studying Glioma - derived Circulating Tumor Cells, while Dr. Fan’s proposal is on the topic of Development of Next-Generation Vasculotherapy by Targeting Vascular Transformation.  Finally, we recognize Dr. Fan on the success of his R01 grant Endothelial Plasticity in Glioma Vascularization and Therapy Resistance.   This award is expected to begin in October of 2015 and includes Radiation Oncology co-investigator Dr. Jay Dorsey.  This is Dr. Fan’s first R01 grant and the Division shares with him our hearty congratulations.

The Research Division congratulates Dr. Andy Minn on receiving the Michael S. Brown New Investigator Research Award. This award is given by the Perelman School of Medicine for the purpose of recognizing emerging investigators who are engaged in innovative discoveries. Dr. Minn was selected for this award based on his work in studying radiation and immune therapies as they relate to the biological basis of therapeutic cancer resistance.

• Evaluation of the cumulative Cherenkov converted dose on TSET patients with multiple Cherenkov cameras.  Zhu Y, Alexander DA, Miao T, Maity A, Plastaras JP, Paydar I, LaRiviere M, Pogue BW, Zhu TC. Proc SPIE Int Soc Opt Eng. 2023 Jan-Feb;12359:1235907. Doi 10.1117/12.2651177. Epub 2023 Mar 14. PMID: 37124379
• Comparison of surface dose during whole breast radiation therapy on Halcyon and TrueBeam using Cherenkov imaging.  Alexander DA, Certa O, Haertter A, Li T, Taunk N, Zhu TC. Proc SPIE Int Soc Opt Eng. 2023 Jan-Feb;12371:1237108. doi: 10.1117/12.2652588. Epub 2023 Mar 6. PMID: 37101538
• Dose prescription and reporting in stereotactic body radiotherapy: A multi-institutional study. Das IJ, Yadav P, Andersen AD, Chen ZJ, Huang L, Langer MP, Lee C, Li L, Popple RA, Rice RK, Schiff PB, Zhu TC, Abazeed ME. Radiother Oncol. 2023 May;182:109571. doi: 10.1016/j.radonc.2023.109571. Epub 2023 Feb 22. PMID: 36822361
• p53 promotes revival stem cells in the regenerating intestine after severe radiation injury. Morral C, Ayyaz A, Kuo HC, Fink M, Verginadis I, Daniel AR, Burner DN, Driver LM, Satow S, Hasapis S, Ghinnagow R, Luo L, Ma Y, Attardi LD, Koumenis C, Minn AJ, Wrana JL, Lee CL, Kirsch DG. bioRxiv. 2023 Apr 28:2023.04.27.538576. doi: 10.1101/2023.04.27.538576. Preprint. PMID: 37162959
• Prospective Feasibility and Phase I/II Trial of Preoperative Proton Beam Therapy with Concurrent Chemotherapy for Resectable Stage IIIA or Superior Sulcus Non-Small Cell Lung Cancer.  Simone CB, Yegya-Raman N, Manjunath S, Verma V, Shabason JE, Xu L, Cengel KA, Levin WP, Berman AT, Christodouleas JP, Aggarwal C, Cohen RB, Langer CJ, Pechet TT, Singal S, Kucharczuk JC, Rengan R, Feigenberg SJ. Int J Radiat Oncol Biol Phys. 2023 May 16:S0360-3016(23)00463-7. doi: 10.1016/j.ijrobp.2023.05.016.  PMID: 37201756
• A real-time IR navigation system for pleural photodynamic therapy with a 3D surface acquisition system.  Sun H, Sourvanos D, Potasek M, Parilov G, Beesonk C, Zhu TC. Proc SPIE Int Soc Opt Eng. 2023 Jan-Feb;12359:123590C. doi: 10.1117/12.2650456. Epub 2023 Mar 14. PMID: 37206987
• PDT Light Fluence Phantom Modeling of the Human Pleural Cavity: A Proof-of-Concept Pre-Clinical Study.  Sourvanos D, Sun H, Cengel KA, Fiorellini JP, Zhu TC. Proc SPIE Int Soc Opt Eng. 2023 Jan-Feb;12359:1235909. doi: 10.1117/12.2654485. Epub 2023 Mar 14. PMID: 37206986
• Validating Homogeneity for a Novel 3-Dimensional Tissue Phantom Modeling System of the Human Maxilla.  Sourvanos D, Hall Morales RD, Dimofte A, Fiorellini JP, Zhu TC. Proc SPIE Int Soc Opt Eng. 2023 Jan-Feb;12362:1236204. doi: 10.1117/12.2654593. Epub 2023 Mar 14. PMID: 37206702
• Photobiomodulation in dental extraction therapy: Postsurgical pain reduction and wound healing.  Sourvanos D, Lander B, Sarmiento H, Carroll J, Hall RD, Zhu TC, Fiorellini JP. J Am Dent Assoc. 2023 May 18:S0002-8177(23)00139-3. doi: 10.1016/j.adaj.2023.03.004.  PMID: 37204376 Review
• An AI-based universal phantom analysis method based on XML-SVG wireframes with novel functional object identifiers.  Sakaamini A, Van Slyke A, Partouche J, Wu T, Wiersma RD. Phys Med Biol. 2023 Jun 2. doi: 10.1088/1361-6560/acdb44.  PMID: 37267994
• Modeling ultra-high dose rate electron and proton FLASH effect with the physicochemical approach.  Tan HS, Teo BK, Dong L, Friberg A, Koumenis C, Diffenderfer E, Zou JW.Phys Med Biol. 2023 Jun 23. doi: 10.1088/1361-6560/ace14d.  PMID: 37352867
• Cardiovascular Substructure Dose and Cardiac Events following Proton- and Photon-Based Chemoradiotherapy for Non-Small Cell Lung Cancer.  Natarajan J, Yegya-Raman N, Kegelman TP, Kallan MJ, Roshkovan L, Katz S, Ky B, Fradley M, Xiao Y, Lee SH, Zhang Z, Langer C, Aggarwal C, Cohen R, Cengel K, Levin W, Berman AT, Feigenberg SJ. Adv Radiat Oncol. 2023 Apr 5;8(5):101235. doi: 10.1016/j.adro.2023.101235. eCollection 2023 Sep-Oct. PMID: 37408679
• Evaluation of Fractionated Photofrin-mediated Photodynamic Therapy Using Different Light Fluences with Reactive Oxygen Species Explicit Dosimetry (ROSED).  Sun H, Rastogi V, Zhu TC. Proc SPIE Int Soc Opt Eng. 2023 Jan-Feb;12359:1235906. doi: 10.1117/12.2650434. Epub 2023 Mar 14. PMID: 37378071
• Updates on radiotherapy-immunotherapy combinations: Proceedings of 6^th annual ImmunoRad conference.  Gregucci F, Spada S, Barcellos-Hoff MH, Bhardwaj N, Chan Wah Hak C, Fiorentino A, Guha C, Guzman ML, Harrington K, Herrera FG, Honeychurch J, Hong T, Iturri L, Jaffee E, Karam SD, Knott SRV, Koumenis C, Lyden D, Marciscano AE, Melcher A, Mondini M, Mondino A, Morris ZS, Pitroda S, Quezada SA, Santambrogio L, Shiao S, Stagg J, Telarovic I, Timmerman R, Vozenin MC, Weichselbaum R, Welsh J, Wilkins A, Xu C, Zappasodi R, Zou W, Bobard A, Demaria S, Galluzzi L, Deutsch E, Formenti SC. Oncoimmunology. 2023 Jun 21;12(1):2222560. doi: 10.1080/2162402X.2023.2222560. eCollection 2023. PMID: 37363104
• RUNX1 is required in granulocyte-monocyte progenitors to attenuate inflammatory cytokine production by neutrophils.  Zezulin AU, Yen D, Ye D, Howell ED, Bresciani E, Diemer J, Ren JG, Ahmad MH, Castilla LH, Touw IP, Minn AJ, Tong W, Liu PP, Tan K, Yu W, Speck NA. Genes Dev. 2023 Aug 3. doi: 10.1101/gad.350418.123.  PMID: 37536952
• Pneumonitis rates before and after adoption of immunotherapy consolidation in patients with locally advanced non-small cell lung cancer treated with concurrent chemoradiation.  Yegya-Raman N, Friedes C, Lee SH, Iocolano M, Duan L, Wang X, Li B, Aggarwal C, Cohen RB, Su W, Doucette A, Levin WP, Cengel KA, DiBardino D, Teo BK, O'Reilly SE, Sun L, Bradley JD, Xiao Y, Langer CJ, Feigenberg SJ. Int J Radiat Oncol Biol Phys. 2023 Aug 22:S0360-3016(23)07815-X. doi: 10.1016/j.ijrobp.2023.08.039.  PMID: 37619788
• Parkin deficiency suppresses antigen presentation to promote tumor immune evasion and immunotherapy resistance.  Perales-Linares R, Leli NM, Mohei H, Beghi S, Rivera OD, Kostopoulos N, Giglio A, George SS, Uribe-Herranz M, Costabile F, Pierini S, Pustylnikov S, Skoufos G, Barash Y, Hatzigeorgiou AG, Koumenis C, Maity A, Lotze MT, Facciabene A. Cancer Res. 2023 Aug 14:CAN-22-2499. doi: 10.1158/0008-5472.CAN-22-2499.  PMID: 37578274
• The integrated stress response in cancer progression: a force for plasticity and resistance.  Lines CL, McGrath MJ, Dorwart T, Conn CS. Front Oncol. 2023 Aug 3;13:1206561. doi: 10.3389/fonc.2023.1206561. eCollection 2023. PMID: 37601686 Free PMC article. Review
• Radiation-Chemical Oxygen Depletion Depends on Chemical Environment and Dose Rate: Implications for the FLASH Effect.  Koch CJ, Kim MM, Wiersma RD. Int J Radiat Oncol Biol Phys. 2023 Sep 1;117(1):214-222. doi: 10.1016/j.ijrobp.2023.04.001. Epub 2023 Apr 13. PMID: 37059234
• Phase II trial of consolidation pembrolizumab after proton reirradiation for thoracic recurrences of non-small cell lung cancer: Pembro after PBT ReRT for NSCLC.  Yegya-Raman N, Berman AT, Ciunci CA, Friedes C, Berlin E, Iocolano M, Wang X, Lai C, Levin WP, Cengel KA, O'Reilly SE, Cohen RB, Aggarwal C, Marmarelis ME, Singh AP, Sun L, Bradley JD, Plastaras JP, Simone CB 2nd, Langer CJ, Feigenberg SJ. Int J Radiat Oncol Biol Phys. 2023 Aug 29:S0360-3016(23)07846-X. doi: 10.1016/j.ijrobp.2023.08.047.  PMID: 37652303
• Surgical Inflammation Alters Immune Response to Intraoperative Photodynamic Therapy.  Davis RW 4th, Klampatsa A, Cramer GM, Kim MM, Miller JM, Yuan M, Houser C, Snyder E, Putt M, Vinogradov SA, Albelda SM, Cengel KA, Busch TM. Cancer Res Commun. 2023 Sep 11;3(9):1810-1822. doi: 10.1158/2767-9764.CRC-22-0494. eCollection 2023 Sep. PMID: 37700795
• Isolation of Epithelial and Stromal Cells from Colon Tissues in Homeostasis and Under Inflammatory Conditions.  Morral C, Ghinnagow R, Karakasheva T, Zhou Y, Thadi A, Li N, Yoshor B, Soto GE, Chen CH, Aleynick D, Weinbrom S, Fulton M, Uzun Y, Bewtra M, Kelsen JR, Lengner CJ, Tan K, Minn AJ, Hamilton KE. Bio Protoc. 2023 Sep 20;13(18):e4825. doi: 10.21769/BioProtoc.4825. eCollection 2023 Sep 20. PMID: 37753470
• One-Year Outcomes Following Stereotactic Body Radiotherapy for Refractory Ventricular Tachycardia.  Arkles J, Markman T, Trevillian R, Yegya-Raman N, Garg L, Nazarian S, Santangeli P, Garcia F, Callans D, Frankel DS, Supple G, Lin D, Riley M, Kumaraeswaran R, Marchlinski F, Schaller R, Desjardins B, Chen H, Apinorasethkul O, Alonso-Basanta M, Diffenderfer E, Kim MM, Feigenberg S, Zou W, Marcel J, Cengel KA. Heart Rhythm. 2023 Oct 10:S1547-5271(23)02782-0. doi: 10.1016/j.hrthm.2023.10.005.  PMID: 37827346
• Patterns of Failure in Metastatic NSCLC Treated With First Line Pembrolizumab and Use of Local Therapy in Patients With Oligoprogression.  Friedes C, Yegya-Raman N, Zhang S, Iocolano M, Cohen RB, Aggarwal C, Thompson JC, Marmarelis ME, Levin WP, Cengel KA, Ciunci CA, Singh AP, D'Avella C, Davis CW, Langer CJ, Feigenberg SJ. Clin Lung Cancer. 2023 Sep 17:S1525-7304(23)00184-5. doi: 10.1016/j.cllc.2023.09.002.  PMID: 37813713
• Characterization of Cherenkov imaging parameters and positional constraints on an O-ring linear accelerator.  Alexander DA, Majji S, Jermyn M, Byrd BK, Bruza P, Li T, Zhu TC. Phys Med Biol. 2023 Oct 13;68(20). doi: 10.1088/1361-6560/acfdf2. PMID: 37757840
• Unedited allogeneic iNKT cells show extended persistence in MHC-mismatched canine recipients.  Rotolo A, Whelan EC, Atherton MJ, Kulikovskaya I, Jarocha D, Fraietta JA, Kim MM, Diffenderfer ES, Cengel KA, Piviani M, Radaelli E, Duran-Struuck R, Mason NJ. Cell Rep Med. 2023 Oct 17;4(10):101241. doi: 10.1016/j.xcrm.2023.101241. PMID: 37852175

• Utilization and Factors Precluding Receipt of Checkpoint Inhibitor Consolidation for Stage III NSCLC in a Large US Academic Health System. Yegya-Raman N, Friedes C, Sun L, Iocolano M, Kim KN, Doucette A, Cohen RB, Robinson KW, Levin WP, Cengel KA, Lally B, Agarwal M, D'Avella CA, Marmarelis ME, Kosteva JA, Singh AP, Ciunci CA, Aggarwal C, Berman AT, Langer CJ, Feigenberg SJ. Clin Lung Cancer. 2023 Apr 3. pii: S1525-7304(23)00054-2. doi: 10.1016/j.cllc.2023.03.013. PMID:37076396 PMID: 37059234

• Radiation Therapy and the Microbiome; More Than a Gut Feeling. Amit U, Facciabene A, Ben-Josef E. Cancer J. 2023 Mar-Apr 01;29(2):84-88. doi: 10.1097/PPO.0000000000000650. Review. PubMed [citation] PMID: 36957978

• Clinical Outcomes Associated With Pembrolizumab Monotherapy Among Adults With Diffuse Malignant Peritoneal Mesothelioma. Marmarelis ME, Wang X, Roshkovan L, Grady CB, Miura JT, Ginsberg MS, Ciunci CA, Egger J, Walker S, Cercek A, Foote MB, Litzky LA, Nash G, Haas AR, Karakousis GC, Cengel KA, Katz SI, Zauderer MG, Langer CJ, Offin M. JAMA Netw Open. 2023 Mar 1;6(3):e232526. doi: 10.1001/jamanetworkopen.2023.2526. PubMed [citation] PMID:36897589

• A Novel Ubiquitin Complex Regulates Aneuploid Epithelial Tumors by Moderating an Integrated Stress Response. Leli NM, Koumenis C. Cancer Discov. 2023 Mar 1;13(3):535-537. doi: 10.1158/2159-8290.CD-22-1440. PubMed [citation] PMID:36855916

• Improving Titanium Implant Stability with Photobiomodulation: A Review and Meta-Analysis of Irradiation Parameters. Sourvanos D, Poon J, Lander B, Sarmiento H, Carroll J, Zhu TC, Fiorellini JP. Photobiomodul Photomed Laser Surg. 2023 Mar;41(3):93-103. doi: 10.1089/photob.2022.0161. Epub 2023 Feb 28. Review. PubMed [citation] PMID:36856530 PMCID: PMC10024586

• PHGDH-mediated endothelial metabolism drives glioblastoma resistance to chimeric antigen receptor T cell immunotherapy. Zhang D, Li AM, Hu G, Huang M, Yang F, Zhang L, Wellen KE, Xu X, Conn CS, Zou W, Kahn M, Rhoades SD, Weljie AM, Fuchs SY, Amankulor N, Yoshor D, Ye J, Koumenis C, Gong Y, Fan Y. Cell Metab. 2023 Mar 7;35(3):517-534.e8. doi: 10.1016/j.cmet.2023.01.010. Epub 2023 Feb 17. PubMed [citation] PMID:36804058 PMCID:PMC10088869

• Small-molecule toosendanin reverses macrophage-mediated immunosuppression to overcome glioblastoma resistance to immunotherapy. Yang F, Zhang D, Jiang H, Ye J, Zhang L, Bagley SJ, Winkler J, Gong Y, Fan Y. Sci Transl Med. 2023 Feb 15;15(683):eabq3558. doi: 10.1126/scitranslmed.abq3558. Epub 2023 Feb 15. PubMed [citation] PMID:36791206

• Salvage radiotherapy for relapsed/refractory non-Hodgkin lymphoma following CD19 chimeric antigen receptor T-cell (CART) therapy. Yegya-Raman N, Wright CM, LaRiviere MJ, Baron JA, Lee DY, Landsburg DJ, Svoboda J, Nasta SD, Gerson JN, Barta SK, Chong EA, Schuster SJ, Maity A, Facciabene A, Paydar I, Plastaras JP. Clin Transl Radiat Oncol. 2023 Jan 20;39:100587. doi: 10.1016/j.ctro.2023.100587. eCollection 2023 Mar. PubMed [citation] PMID:36718252 PMCID:PMC9883177

• Cancer cells resistant to immune checkpoint blockade acquire interferon-associated epigenetic memory to sustain T cell dysfunction. Qiu J, Xu B, Ye D, Ren D, Wang S, Benci JL, Xu Y, Ishwaran H, Beltra JC, Wherry EJ, Shi J, Minn AJ. Nat Cancer. 2023 Jan;4(1):43-61. doi: 10.1038/s43018-022-00490-y. Epub 2023 Jan 16. PubMed [citation] PMID:36646856

• Modulation of the gut microbiota engages antigen cross-presentation to enhance antitumor effects of CAR T cell immunotherapy. Uribe-Herranz M, Beghi S, Ruella M, Parvathaneni K, Salaris S, Kostopoulos N, George SS, Pierini S, Krimitza E, Costabile F, Ghilardi G, Amelsberg KV, Lee YG, Pajarillo R, Markmann C, McGettigan-Croce B, Agarwal D, Frey N, Lacey SF, Scholler J, Gabunia K, Wu G, et al. Mol Ther. 2023 Mar 1;31(3):686-700. doi: 10.1016/j.ymthe.2023.01.012. Epub 2023 Jan 14. PubMed [citation] PMID:36641624 PMCID:PMC10014349

• Toxicities and Deaths From Intercurrent Disease Following Contemporary Postoperative Radiotherapy in Resected Non-Small-Cell Lung Cancer. Kim KN, Heintz J, Yegya-Raman N, Cohen R, Kegelman T, Cengel K, Marmarelis M, Sun L, Langer C, Aggarwal C, Singh A, Singhal S, Kucharczuk J, Robinson K, Feigenberg S. Clin Lung Cancer. 2023 Mar;24(2):e78-e86. doi: 10.1016/j.cllc.2022.12.008. Epub 2022 Dec 25. PubMed [citation] PMID:36628846

• Roadmap for precision preclinical x-ray radiation studies. Verhaegen F, Butterworth KT, Chalmers AJ, Coppes RP, de Ruysscher D, Dobiasch S, Fenwick JD, Granton PV, Heijmans SHJ, Hill MA, Koumenis C, Lauber K, Marples B, Parodi K, Persoon LCGG, Staut N, Subiel A, Vaes RDW, van Hoof S, Verginadis IL, Wilkens JJ, Williams KJ, et al. Phys Med Biol. 2023 Mar 31;68(6). doi: 10.1088/1361-6560/acaf45. Review. PubMed [citation] PMID: 36584393

• In vivo spectroscopic evaluation of human tissue optical properties and hemodynamics during HPPH-mediated photodynamic therapy of pleural malignancies. Morales RDH, Hong Ong Y, Finlay J, Dimofte A, Simone CB, Friedberg JS, Busch TM, Cengel KA, Zhu TC. J Biomed Opt. 2022 Oct;27(10). doi: 10.1117/1.JBO.27.10.105006. PubMed [citation] PMID:36316298 PMCID:PMC9621284

• Gamma Knife radiosurgery for trigeminal neuralgia provides greater pain relief at higher dose rates. Yang AI, Mensah-Brown KG, Shekhtman EF, Kvint S, Wathen CA, Hitti FL, Alonso-Basanta M, Avery SM, Dorsey JF, Y K Lee J. J Radiosurg SBRT. 2022;8(2):117-125. PubMed [citation] PMID:36275137 PMCID:PMC9489081

• A single-center retrospective cohort study of perioperative systemic chemotherapy in diffuse malignant peritoneal mesothelioma. Wang X, Katz S, Miura J, Karakousis G, Roshkovan L, Walker S, McNulty S, Ciunci C, Cengel K, Langer CJ, Marmarelis ME. PLoS One. 2022 Sep 29;17(9):e0275187. doi: 10.1371/journal.pone.0275187. eCollection 2022. PubMed [citation] PMID:36174024 PMCID:PMC9521908

• Distinct Cell Adhesion Signature Defines Glioblastoma Myeloid-Derived Suppressor Cell Subsets. Bayik D, Bartels CF, Lovrenert K, Watson DC, Zhang D, Kay K, Lee J, Lauko A, Johnson S, Lo A, Silver DJ, McGraw M, Grabowski M, Mohammadi AM, Veglia F, Fan Y, Vogelbaum MA, Scacheri P, Lathia JD. Cancer Res. 2022 Nov 15;82(22):4274-4287. doi: 10.1158/0008-5472.CAN-21-3840. PubMed [citation] PMID:36126163 PMCID:PMC9664137

• ATF3 and CH25H regulate effector trogocytosis and anti-tumor activities of endogenous and immunotherapeutic cytotoxic T lymphocytes. Lu Z, McBrearty N, Chen J, Tomar VS, Zhang H, De Rosa G, Tan A, Weljie AM, Beiting DP, Miao Z, George SS, Berger A, Saggu G, Diehl JA, Koumenis C, Fuchs SY. Cell Metab. 2022 Sep 6;34(9):1342-1358.e7. doi: 10.1016/j.cmet.2022.08.007. PubMed [citation] PMID:36070682

• Induction of the activating transcription factor-4 in the intratumoral CD8+ T cells sustains their viability and anti-tumor activities. Lu Z, Bae EA, Verginadis II, Zhang H, Cho C, McBrearty N, George SS, Diehl JA, Koumenis C, Bradley LM, Fuchs SY. Cancer Immunol Immunother. 2023 Apr;72(4):815-826. doi: 10.1007/s00262-022-03286-2. Epub 2022 Sep 5. PubMed [citation] PMID:36063172

• Loss of AID exacerbates the malignant progression of CLL. Lee AC, Pingali SR, Pinilla-Ibarz JA, Atchison ML, Koumenis C, Argon Y, Thomas-Tikhonenko A, De Trez C, Hu CA, Tang CA. Leukemia. 2022 Oct;36(10):2430-2442. doi: 10.1038/s41375-022-01663-5. Epub 2022 Aug 30. PubMed [citation] PMID: 36042317 PMCID: PMC9522595

• Evaluation of Detector Position and Light Fluence Distribution Using an Infrared Navigation System during Pleural Photodynamic Therapy(†). Sun H, Kim MM, Ong YH, Dimoft A, Singhal S, Busch TM, Cengel KA, Zhu TC. Photochem Photobiol. 2023 Mar;99(2):814-825. doi: 10.1111/php.13697. Epub 2022 Sep 16. PubMed [citation] PMID: 35996976 PMCID: PMC9947188

• Skin dose distributions between Stanford and rotational techniques in total skin electron therapy (TSET). Ding GX, Chen ZJ, Zhong W, Zhu TC. Med Phys. 2022 Oct;49(10):6646-6653. doi: 10.1002/mp.15907. Epub 2022 Aug 23. PubMed [citation] PMID: 35972019

• Renally Excretable Silver Telluride Nanoparticles as Contrast Agents for X-ray Imaging. Nieves LM, Dong YC, Rosario-Berríos DN, Mossburg K, Hsu JC, Cramer GM, Busch TM, Maidment ADA, Cormode DP. ACS Appl Mater Interfaces. 2022 Aug 3;14(30):34354-34364. doi: 10.1021/acsami.2c06190. Epub 2022 Jul 22. PubMed [citation] PMID: 35867906 PMCID: PMC9482380

• Erratum: "Report of AAPM Task Group 219 on independent calculation-based dose/MU verification for IMRT". Zhu TC, Stathakis S, Clark JR, Feng W, Georg D, Holmes SM, Kry SF, Charlie Ma CM, Miften M, Mihailidis D, Moran JM, Papanikolaou N, Poppe B, Xiao Y. Med Phys. 2022 Aug;49(8):5713. doi: 10.1002/mp.15772. Epub 2022 Jul 14. No abstract available. PubMed [citation] PMID: 35833598

• Disease Outcomes Following Low-Dose Radiotherapy vs. Moderate-Dose Radiotherapy for Orbital Low Grade Non-Hodgkin Lymphoma.  Wright CM, Baron J, Lee DY, Carpenter M, Anstadt EJ, Briceño CA, Chong EA, Maity A, Plastaras JP, Paydar I. Int J Radiat Oncol Biol Phys. 2021 Nov 1;111(3S):e307-e308. doi: 10.1016/j.ijrobp.2021.07.959. PMID: 34701143
• Radiation Therapy (RT)-Based Salvage Therapy for Classical Hodgkin Lymphoma (cHL).  Manjunath SH, Larose MI, Carpenter M, Svoboda J, Paydar I, Maity A, Landsburg DJ, Nasta SD, Schuster S, Plastaras JP. Int J Radiat Oncol Biol Phys. 2021 Nov 1;111(3S):e305. doi: 10.1016/j.ijrobp.2021.07.954. PMID: 34701138
• Final Results of a Phase I "RadVax" Trial of Hypofractionated Radiation Combined With Pembrolizumab in Patients With Metastatic Solid Tumors.  Lukens JN, Mick R, Huang AC, Han N, Farwell MD, Mitchell TC, Amaravadi R, Schuchter LM, Berman AT, O'Hara M, Maity A, Miller D, Minn AJ 3rd, Vonderheide RH, Wherry EJ, Maity A. Int J Radiat Oncol Biol Phys. 2021 Nov 1;111(3S):S67-S68. doi: 10.1016/j.ijrobp.2021.07.168. PMID: 34700607
• Salvage Radiotherapy for Relapsed/Refractory Non-Hodgkin Lymphomas Following CD19 Chimeric Antigen Receptor T-Cell (CART) Therapy.  Wright CM, Yegya-Raman N, Baron J, Lee DY, Chong EA, LaRiviere MJ, Maity A, Plastaras JP, Paydar I. Int J Radiat Oncol Biol Phys. 2021 Nov 1;111(3S):S132-S133. doi: 10.1016/j.ijrobp.2021.07.300. PMID: 34700462
• Circulating Tumor Cell Assay Enables Prediction of Recurrence Following Stereotactic Body Radiotherapy for Early-Stage Non-Small Cell Lung Cancer: An Interpretable Machine Learning Study.  Zhang Z, Lee SH, Caruana R, Fan Y, Kao GD, Feigenberg SJ, Xiao Y. Int J Radiat Oncol Biol Phys. 2021 Nov 1;111(3S):e123. doi: 10.1016/j.ijrobp.2021.07.544. PMID: 34700728
• Ultra-Fast Oxygen Monitoring During Proton FLASH Delivery Using the Phosphorescence Quenching Method and Soluble Oxyphor Probes.  Van Slyke AL, El Khatib M, Shoniyozov K, Diffenderfer ES, Kim MM, Koch CJ, Vinogradov SA, Wiersma RD. Int J Radiat Oncol Biol Phys. 2021 Nov 1;111(3S):S31-S32. doi: 10.1016/j.ijrobp.2021.07.098. PMID: 34700531
• Initial Report of Clinical Outcomes and Acute Toxicities Following Reirradiation of Primary Brain Tumors.  Wei J, Santos P, Lustig RA, Kurtz G, Dorsey JF, Shabason JE Jr, Alonso-Basanta M. Int J Radiat Oncol Biol Phys. 2021 Nov 1;111(3S):e604. doi: 10.1016/j.ijrobp.2021.07.1611. PMID: 34701856

• The Cancer Surfaceome Atlas integrates genomic, functional and drug response data to identify actionable targets. Hu H, Yuan J, Long M, Jiang J, Zhang Y, Zhang T, Xu M, Fan Y, Tanyi JL, Montone KT, Tavana O, Chan HM, Hu X, Vonderheide RH, & Zhang L. Nature Cancer 2021 Dec 13; 2, 1406–1422.

• Loss of p19Arf Promotes Fibroblast Survival During Leucine Deprivation.  Roby KC, Lieberman A, Kim BJ, Rodríguez NZ, Posimo JM, Tsang T, Verginadis II, Puré E, Brady DC, Koumenis C, Ryeom S. Biol Open. 2022 Jan 7:bio.058728. doi: 10.1242/bio.058728. PMID: 34994382

• Vascular Microenvironment, Tumor Immunity and Immunotherapy.  Lamplugh Z, Fan Y. Front Immunol. 2021 Dec 20;12:811485. doi: 10.3389/fimmu.2021.811485. eCollection 2021. PMID: 34987525 Free PMC article. Review.
• MR susceptibility imaging for detection of tumor-associated macrophages in glioblastoma.  Nazem A, Guiry SC, Pourfathi M, Ware JB, Anderson H, Iyer SK, Moon BF, Fan Y, Witschey WR, Rizi R, Bagley SJ, Desai A, O'Rourke DM, Brem S, Nasrallah M, Nabavizadeh A. J Neurooncol. 2022 Jan 19. doi: 10.1007/s11060-022-03947-3.  PMID: 35043276
• Forging Forward in Photodynamic Therapy.  Cramer GM, Cengel KA, Busch TM. Cancer Res. 2022 Feb 15;82(4):534-536. doi: 10.1158/0008-5472.CAN-21-4122. PMID: 35180305
• Radiomic Phenotypes for Improving Early Prediction of Survival in Stage III Non-Small Cell Lung Cancer Adenocarcinoma after Chemoradiation.  Luna JM, Barsky AR, Shinohara RT, Roshkovan L, Hershman M, Dreyfuss AD, Horng H, Lou C, Noël PB, Cengel KA, Katz S, Diffenderfer ES, Kontos D. Cancers (Basel). 2022 Jan 29;14(3):700. doi: 10.3390/cancers14030700. PMID: 35158971
• Integration of Deep Learning Radiomics and Counts of Circulating Tumor Cells Improves Prediction of Outcomes of Early Stage NSCLC Patients Treated With Stereotactic Body Radiation Therapy.  Jiao Z, Li H, Xiao Y, Dorsey J, Simone CB, Feigenberg S, Kao G, Fan Y. Int J Radiat Oncol Biol Phys. 2022 Mar 15;112(4):1045-1054. doi: 10.1016/j.ijrobp.2021.11.006. Epub 2021 Nov 11. PMID: 34775000
• Gut microbiome correlates of response and toxicity following anti-CD19 CAR T cell therapy.  Smith M, Dai A, Ghilardi G, Amelsberg KV, Devlin SM, Pajarillo R, Slingerland JB, Beghi S, Herrera PS, Giardina P, Clurman A, Dwomoh E, Armijo G, Gomes ALC, Littmann ER, Schluter J, Fontana E, Taur Y, Park JH, Palomba ML, Halton E, Ruiz J, Jain T, Pennisi M, Afuye AO, Perales MA, Freyer CW, Garfall A, Gier S, Nasta S, Landsburg D, Gerson J, Svoboda J, Cross J, Chong EA, Giralt S, Gill SI, Riviere I, Porter DL, Schuster SJ, Sadelain M, Frey N, Brentjens RJ, June CH, Pamer EG, Peled JU, Facciabene A, van den Brink MRM, Ruella M. Nat Med. 2022 Mar 14. doi: 10.1038/s41591-022-01702-9. Online ahead of print. PMID: 35288695
• Ultrafast Tracking of Oxygen Dynamics during Proton FLASH.  Khatib ME, Van Slyke AL, Velalopoulou A, Kim MM, Shoniyozov K, Allu SR, Diffenderfer EE, Busch TM, Wiersma RD, Koch CJ, Vinogradov SA. Int J Radiat Oncol Biol Phys. 2022 Mar 18:S0360-3016(22)00249-8. doi: 10.1016/j.ijrobp.2022.03.016. Online ahead of print. PMID: 35314293
• Cell plasticity, senescence, and quiescence in cancer stem cells: Biological and therapeutic implications.  Paul R, Dorsey JF, Fan Y. Pharmacol Ther. 2022 Mar;231:107985. doi: 10.1016/j.pharmthera.2021.107985. Epub 2021 Sep 1. PMID: 34480963 Review.
• Key biological mechanisms involved in high-LET radiation therapies with a focus on DNA damage and repair.  Nikitaki Z, Velalopoulou A, Zanni V, Tremi I, Havaki S, Kokkoris M, Gorgoulis VG, Koumenis C, Georgakilas AG. Expert Rev Mol Med. 2022 Mar 31;24:e15. doi: 10.1017/erm.2022.6. PMID: 35357290 Review.
• Transient expansion and myofibroblast conversion of adipogenic lineage precursors mediate bone marrow repair after radiation.  Zhong L, Yao L, Holdreith N, Yu W, Gui T, Miao Z, Elkaim Y, Li M, Gong Y, Pacifici M, Maity A, Busch TM, Joeng KS, Cengel K, Seale P, Tong W, Qin L. JCI Insight. 2022 Apr 8;7(7):e150323. doi: 10.1172/jci.insight.150323. PMID: 35393948
• The interferon-stimulated gene RIPK1 regulates cancer cell intrinsic and extrinsic resistance to immune checkpoint blockade.  Cucolo L, Chen Q, Qiu J, Yu Y, Klapholz M, Budinich KA, Zhang Z, Shao Y, Brodsky IE, Jordan MS, Gilliland DG, Zhang NR, Shi J, Minn AJ. Immunity. 2022 Apr 12;55(4):671-685.e10. doi: 10.1016/j.immuni.2022.03.007. PMID: 35417675
• Editorial: Deciphering the Microbiome-Immunity-Cancer Axis.  Chen X, Jin C, Facciabene A, Guo X, Zhang Y. Front Immunol. 2022 Apr 14;13:897811. doi: 10.3389/fimmu.2022.897811. eCollection 2022. PMID: 35493451
• Monte Carlo simulation of Cherenkov imaging for Total Skin Electron Treatment with CT DICOM realistic patient geometry.  Zhong W, Ong Y, Miao T, Pogue BW, Zhu TC. Proc SPIE Int Soc Opt Eng. 2022 Jan-Feb;11940:1194009. doi: 10.1117/12.2609027. Epub 2022 Mar 4. PMID: 35506008
• Validation of multispectral singlet oxygen luminescence dosimetry (MSOLD) for photofrin-mediated photodynamic therapy.  Hall Morales RD, Sun H, Hong Ong Y, Zhu TC. Proc SPIE Int Soc Opt Eng. 2022 Jan-Feb;11940:119400J. doi: 10.1117/12.2609937. Epub 2022 Mar 4. PMID: 35506009
• Endothelial plasticity drives aberrant vascularization and impedes cardiac repair after myocardial infarction.  Huang M, Yang F, Zhang D, Lin M, Duan H, El-Mayta R, Zhang L, Qin L, Shewale SV, Pei L, Mitchell MJ, Rader DJ, Fan Y, Gong Y. Nat Cardiovasc Res. 2022 Apr;1(4):372-388. doi: 10.1038/s44161-022-00047-3.  2022 Apr 13. PMID: 35571674
• Real-time PDT Dose Dosimetry for Pleural Photodynamic Therapy.  Zhu TC, Sun H, Ong YH, Morales RH, Dimofte A, Busch T, Singhal S, Cengel KA. Proc SPIE Int Soc Opt Eng. 2022 Jan-Feb;11940:1194002. doi: 10.1117/12.2612188. Epub 2022 Mar 4. PMID: 35573026
• Clinical measures, radiomics, and genomics offer synergistic value in AI-based prediction of overall survival in patients with glioblastoma.  Fathi Kazerooni A, Saxena S, Toorens E, Tu D, Bashyam V, Akbari H, Mamourian E, Sako C, Koumenis C, Verginadis I, Verma R, Shinohara RT, Desai AS, Lustig RA, Brem S, Mohan S, Bagley SJ, Ganguly T, O'Rourke DM, Bakas S, Nasrallah MP, Davatzikos C. Sci Rep. 2022 May 24;12(1):8784. doi: 10.1038/s41598-022-12699-z. PMID: 35610333
• Improving the efficiency of small animal 3D printed compensator IMRT with beamlet intensity total variation regularization.  Liu X, Van Slyke AL, Pearson E, Shoniyozov K, Redler G, Wiersma RD. Med Phys. 2022 May 24. doi: 10.1002/mp.15764. Online ahead of print. PMID: 35608256
• Targeting PARP11 to avert immunosuppression and improve CAR T therapy in solid tumors.  Zhang H, Yu P, Tomar VS, Chen X, Atherton MJ, Lu Z, Zhang HG, Li S, Ortiz A, Gui J, Leu NA, Yan F, Blanco A, Meyer-Ficca ML, Meyer RG, Beiting DP, Li J, Nunez-Cruz S, O'Connor RS, Johnson LR, Minn AJ, George SS, Koumenis C, Diehl JA, Milone MC, Zheng H, Fuchs SY. Nat Cancer. 2022 May 30. doi: 10.1038/s43018-022-00383-0. Online ahead of print. PMID: 35637402
• Oxygen Monitoring in Model Solutions and In Vivo in Mice During Proton Irradiation at conventional and FLASH Dose Rates.  Van Slyke AL, El Khatib M, Velalopoulou A, Diffenderfer E, Shoniyozov K, Kim MM, Karagounis IV, Busch TM, Vinogradov SA, Koch CJ, Wiersma RD. Radiat Res. 2022 May 31. doi: 10.1667/RADE-21-00232.1. Online ahead of print. PMID: 35640166
• Moderate Colitis Not Requiring IV Steroids Is Associated with Improved Survival in Stage IV Melanoma after Anti-CTLA4 Monotherapy, But Not Combination Therapy.  Anstadt EJ, Chu B, Yegya-Raman N, Han X, Doucette A, Poirier K, Mohiuddin JJ, Maity A, Facciabene A, Amaravadi RK, Karakousis GC, Cohen JV, Mitchell TC, Schuchter LM, Lukens JN. Oncologist. 2022 Jun 6:oyac108. doi: 10.1093/oncolo/oyac108. Online ahead of print. PMID: 35666292
• A stromal Integrated Stress Response activates perivascular cancer-associated fibroblasts to drive angiogenesis and tumour progression.  Verginadis II, Avgousti H, Monslow J, Skoufos G, Chinga F, Kim K, Leli NM, Karagounis IV, Bell BI, Velalopoulou A, Salinas CS, Wu VS, Li Y, Ye J, Scott DA, Osterman AL, Sengupta A, Weljie A, Huang M, Zhang D, Fan Y, Radaelli E, Tobias JW, Rambow F, Karras P, Marine JC, Xu X, Hatzigeorgiou AG, Ryeom S, Diehl JA, Fuchs SY, Puré E, Koumenis C. Nat Cell Biol. 2022 Jun;24(6):940-953. doi: 10.1038/s41556-022-00918-8. Epub 2022 Jun 2. PMID: 35654839
• Shining a FLASHlight on ultrahigh dose rate radiation and possible late toxicity.  Maity A, Koumenis C. Clin Cancer Res. 2022 Jun 23: clincanres.1255.2022-5-10 22:17:03.080. doi: 10.1158/1078-0432.CCR-22-1255. Online ahead of print. PMID: 35736814
• Initial clinical experience treating patients with palliative radiotherapy for malignant pleural mesothelioma on the HalcyonTM linear accelerator. Barsky AR, Kim MM, Maxwell R, Mendes A, Wright CM, Anstadt EJ, McNulty S, Dong L, Metz JM, Feigenberg SJ, Li T, Cengel KA. Ann Palliat Med. 2020 Aug 14:apm-20-385. doi: 10.21037/apm-20-385. Online ahead of print. PMID: 32819128
• Rapid tumor vaccine using Toll-like receptor-activated ovarian cancer ascites monocytes.  Adams SF, Grimm AJ, Chiang CL, Mookerjee A, Flies D, Jean S, McCann GA, Michaux J, Pak H, Huber F, Neal C, Dangaj D, Bassani-Sternberg M, Rusakiewicz S, Facciabene A, Coukos G, Gimotty PA, Kandalaft LE. J Immunother Cancer. 2020 Aug;8(2):e000875. doi: 10.1136/jitc-2020-000875. PMID: 32817208
• Ovarian granulosa cell tumor characterization identifies FOXL2 as an immunotherapeutic target. Pierini S, Tanyi JL, Simpkins F, George E, Uribe-Herranz M, Drapkin R, Burger R, Morgan MA, Facciabene A. JCI Insight. 2020 Aug 20;5(16):136773. doi: 10.1172/jci.insight.136773. PMID: 32814714
• Risk of pneumonitis and outcomes after mediastinal proton therapy for relapsed/refractory lymphoma: A PTCOG and PCG collaboration.  Tseng YD, Hoppe BS, Dedeckova K, Patel CG, Hill-Kayser CE, Miller DM, Maity A, Mendenhall NP, Mailhot RB, Yock TI, Baliga S, Hess CB, Winkfield KM, Mohindra P, Rosen LR, Tsai H, Chang J, Hartsell WF, Plastaras JP. Int J Radiat Oncol Biol Phys. 2020 Aug 28:S0360-3016(20)34202-4. doi: 10.1016/j.ijrobp.2020.08.055. Online ahead of print. PMID: 32866566
• Cell Cycle Checkpoints Cooperate to Suppress DNA- and RNA-Associated Molecular Pattern Recognition and Anti-Tumor Immune Responses.  Chen J, Harding SM, Natesan R, Tian L, Benci JL, Li W, Minn AJ, Asangani IA, Greenberg RA. Cell Rep. 2020 Sep 1;32(9):108080. doi: 10.1016/j.celrep.2020.108080. PMID: 32877684
• Combined fluorescence-guided surgery and photodynamic therapy for glioblastoma multiforme using cyanine and chlorin nanocluster. Teng CW, Amirshaghaghi A, Cho SS, Cai SS, De Ravin E, Singh Y, Miller J, Sheikh S, Delikatny E, Cheng Z, Busch TM, Dorsey JF, Singhal S, Tsourkas A, Lee JYK. J Neurooncol. 2020 Sep 10. doi: 10.1007/s11060-020-03618-1. Online ahead of print. PMID: 32914293
• Higher Dose Volumes May Be Better for Evaluating Radiation Pneumonitis in Lung Proton Therapy Patients Compared With Traditional Photon-Based Dose Constraints.  Harris WB, Zou W, Cheng C, Jain V, Teo BK, Dong L, Feigenberg SJ, Berman AT, Levin WP, Cengel KA, O'Reilly SE. Adv Radiat Oncol. 2020 Jun 29;5(5):943-950. doi: 10.1016/j.adro.2020.06.023. eCollection 2020 Sep-Oct. PMID: 33083657
• Initial Clinical Experience Treating Patients With Lung Cancer on a 6MV-Flattening-Filter-Free O-Ring Linear Accelerator.  Barsky AR, Lin H, Mendes A, Dreyfuss A, Wright C, Anstadt EJ, Berman AT, Levin WP, Cengel KA, Anderson N, Dong L, Metz JM, Li T, Feigenberg S. Cureus. 2020 Sep 9;12(9):e10325. doi: 10.7759/cureus.10325. PMID: 33052286
• Tertiary Amine-Ethylene Glycol Based Tandem CO2 Capture and Hydrogenation to Methanol: Direct Utilization of Post-Combustion CO2.  Prakash SG, Sen R, Koch CJ, Goeppert A. ChemSusChem. 2020 Oct 19. doi: 10.1002/cssc.202002285. Online ahead of print. PMID: 33075206
• Low-Dose Total Skin Electron Beam Therapy as Part of a Multimodality Regimen for Treatment of Sézary Syndrome: Clinical, Immunologic, and Molecular Analysis.  Durgin JS, Jariwala NN, Wysocka M, Zhang KK, Maity A, Benoit B, Plastaras JP, Lewis DJ, Rosenthal JM, Teague JE, Berg S, Del Guzzo C, Kim EJ, Vittorio C, Haun PL, Samimi SS, Villasenor-Park J, Inverso J, Clark RA, Rook AH. JAMA Dermatol. 2020 Oct 28. doi: 10.1001/jamadermatol.2020.3958. Online ahead of print. PMID: 33112366
• Mechanism and Model of a Soft Robot for Head Stabilization in Cancer Radiation Therapy.  Ogunmolu O, Liu X, Gans N, Wiersma RD. IEEE Int Conf Robot Autom. 2020 May-Aug;2020:4609-4615. Doi 10.1109/icra40945.2020.9197007. Epub 2020 Sep 15. PMID: 33133751
• Current Delivery Limitations of Proton PBS for FLASH.  Zou W, Diffenderfer ES, Cengel K, Kim M, Avery S, Konzer J, Cai Y, Boisseu P, Ota K, Yin L, Wiersma R, Carlson DJ, Fan Y, Busch TM, Koumenis C, Lin A, Metz JM, Teo BK, Dong L. Radiother Oncol. 2020 Nov 10:S0167-8140(20)30891-4. doi: 10.1016/j.radonc.2020.11.002.  PMID: 33186682
• Effects of ultra-high dose rate FLASH irradiation on the tumor microenvironment in Lewis lung carcinoma: role of myosin light chain.  Kim YE, Gwak SH, Hong BJ, Oh JM, Choi HS, Kim MS, Oh D, Lartey F, Rafat M, Schüler E, Kim HS, von Eyben R, Weissman IL, Koch CJ, Maxim PG, Loo BW, Ahn GO. Int J Radiat Oncol Biol Phys. 2020 Nov 10:S0360-3016(20)34500-4. doi: 10.1016/j.ijrobp.2020.11.012.  PMID: 33186615
• Early Changes in Physical Activity and Quality of Life with Thoracic Radiation Therapy in Breast Cancer, Lung Cancer, and Lymphoma.  Krishnan S, Narayan HK, Freedman G, Plastaras JP, Maity A, Demissei B, Smith AM, Berman AT, Cengel K, Levin W, Swisher-McClure S, Feigenberg S, Ky B. Int J Radiat Oncol Biol Phys. 2020 Oct 24:S0360-3016(20)34406-0. doi: 10.1016/j.ijrobp.2020.10.018.  PMID: 33223046
• Integration of risk survival measures estimated from pre- and post-treatment CT scans improves stratification of early stage non-small cell lung cancer patients treated with stereotactic body radiation therapy.  Jiao Z, Li H, Xiao Y, Aggarwal C, Galperin-Aizenberg M, Pryma D, Simone CB 2nd, Feigenberg SJ, Kao GD, Fan Y. Int J Radiat Oncol Biol Phys. 2020 Dec 14:S0360-3016(20)34660-5. doi: 10.1016/j.ijrobp.2020.12.014.  PMID: 33333202
• Small animal IMRT using 3D printed compensators.  Redler G, Pearson E, Liu X, Gertsenshteyn I, Epel B, Pelizzari C, Aydogan B, Weichselbaum R, Halpern HJ, Wiersma RD. Int J Radiat Oncol Biol Phys. 2020 Dec 26: S0360-3016(20)34693-9. doi: 10.1016/j.ijrobp.2020.12.028.  PMID: 33373659
• CT for detection of malignant posterior intercostal lymph nodes in patients undergoing pre-operative staging for malignant pleural mesothelioma. Berger I, Simpson S, Friedberg JS, Culligan MJ, Wileyto EP, Alley EW, Sterman D, Patel AM, Khalid U, Simone CB 2nd, Cengel KA, Katz SI, Roshkovan L. Lung Cancer. 2020 Dec 4; 152:34-38. doi: 10.1016/j.lungcan.2020.12.003.  PMID: 33341086
• Estrogen receptor β-mediated inhibition of actin-based cell migration suppresses metastasis of inflammatory breast cancer. Thomas C, Karagounis IV, Srivastava RK, Vrettos N, Nikolos F, Francois N, Huang M, Gong S, Long Q, Kumar S, Koumenis C, Krishnamurthy S, Ueno NT, Chakrabarti R, Maity A. Cancer Res. 2021 Jan 29:canres.2743.2020. doi: 10.1158/0008-5472.CAN-20-2743. Online ahead of print. PMID: 33514514
• Combination of vasculature targeting, hypofractionated radiotherapy, and immune checkpoint inhibitor elicits potent antitumor immune response and blocks tumor progression.  Pierini S, Mishra A, Perales-Linares R, Uribe-Herranz M, Beghi S, Giglio A, Pustylnikov S, Costabile F, Rafail S, Amici A, Facciponte JG, Koumenis C, Facciabene A. J Immunother Cancer. 2021 Feb;9(2):e001636. doi: 10.1136/jitc-2020-001636. PMID: 33563772
• Serum soluble mesothelin-related protein (SMRP) and fibulin-3 levels correlate with baseline malignant pleural mesothelioma (MPM) tumor volumes but are not useful as biomarkers of response in an immunotherapy trial. Katz SI, Roshkovan L, Berger I, Friedberg JS, Alley EW, Simone CB 2nd, Haas AR, Cengel KA, Sterman DH, Albelda SM. Lung Cancer. 2021 Jan 14;154:5-12. doi: 10.1016/j.lungcan.2021.01.011. Online ahead of print. PMID: 33561782
• A novel mouse model of radiation-induced cardiac injury reveals biological and radiological biomarkers of cardiac dysfunction with potential clinical relevance.  Dreyfuss AD, Goia D, Shoniyozov K, Shewale SV, Velalopoulou A, Mazzoni S, Avgousti H, Metzler SD, Bravo PE, Feigenberg SJ, Ky B, Verginadis II, Koumenis C. Clin Cancer Res. 2021 Feb 4:clincanres.3882.2020. doi: 10.1158/1078-0432.CCR-20-3882. Online ahead of print. PMID: 33542079
• Personal and Prognostic: Tissue and Liquid Biomarkers of Radiotherapeutic Response in Non-Small Cell Lung Cancer.  Jean-Baptiste SR, Feigenberg SJ, Dorsey JF, Kao GD. Semin Radiat Oncol. 2021 Apr;31(2):149-154. doi: 10.1016/j.semradonc.2020.11.002. PMID: 33610272 Review.
• The major cap-binding protein eIF4E regulates lipid homeostasis and diet-induced obesity.  Conn CS, Yang H, Tom HJ, Ikeda K, Oses-Prieto JA, Vu H, Oguri Y, Nair S, Gill RM, Kajimura S, DeBerardinis RJ, Burlingame AL, Ruggero D. Nat Metab. 2021 Feb;3(2):244-257. doi: 10.1038/s42255-021-00349-z. Epub 2021 Feb 18. PMID: 33619378
• Multi-block Discriminant Analysis of Integrative ¹⁸F-FDG-PET/CT Radiomics for Predicting Circulating Tumor Cells in Early Stage Non-small Cell Lung Cancer Treated with Stereotactic Body Radiation Therapy.  Lee SH, Kao GD, Feigenberg SJ, Dorsey JF, Frick MA, Jean-Baptiste S, Uche CZ, Cengel KA, Levin WP, Berman AT, Aggarwal C, Fan Y, Xiao Y. Int J Radiat Oncol Biol Phys. 2021 Mar 1:S0360-3016(21)00208-X. doi: 10.1016/j.ijrobp.2021.02.030. Online ahead of print. PMID: 33662459
• A stratified phase I dose escalation trial of hypofractionated radiotherapy followed by ipilimumab in metastatic melanoma: long-term follow-up and final outcomes.  Maity A, Mick R, Rengan R, Mitchell TC, Amaravadi RK, Schuchter LM, Pryma DA, Patsch DM, Maity AP, Minn AJ, Vonderheide RH, Lukens JN. Oncoimmunology. 2021 Jan 31;10(1):1863631. doi: 10.1080/2162402X.2020.1863631. PMID: 33643689
• Managing oligoprogressive malignant pleural mesothelioma with stereotactic body radiation therapy.  Barsky AR, Yegya-Raman N, Katz SI, Simone CB 2nd, Cengel KA. Lung Cancer. 2021 Mar 2:S0169-5002(21)00093-3. doi: 10.1016/j.lungcan.2021.02.033. Online ahead of print. PMID: 33678456.
• Characterization of a high-resolution 2D transmission ion chamber for independent validation of proton pencil beam scanning of conventional and FLASH dose delivery.  Zou W, Diffenderfer ES, Ota K, Boisseau P, Kim MM, Cai Y, Avery SM, Carlson DJ, Wiersma RD, Lin A, Koumenis C, Cengal K, Metz JM, Dong L, Teo BK. Med Phys. 2021 Apr 12. doi: 10.1002/mp.14882. Online ahead of print. PMID: 33843065
• Preclinical Evaluation of Cetuximab and Benzoporphyrin Derivative-Mediated Intraperitoneal Photodynamic Therapy in a Canine Model.  Cramer G, Lewis R, Gymarty A, Hagan S, Mickler M, Evans S, Punekar SR, Shuman L, Simone CB 2nd, Hahn SM, Busch TM, Fraker D, Cengel KA. Photochem Photobiol. 2020 May;96(3):684-691. doi: 10.1111/php.13247. Epub 2020 Apr 27. PMID: 32119123
• Phase 1 trial of nelfinavir added to standard cisplatin chemotherapy with concurrent pelvic radiation for locally advanced cervical cancer.  Garcia-Soto AE, McKenzie ND, Whicker ME, Pearson JM, Jimenez EA, Portelance L, Hu JJ, Lucci JA 3rd, Qureshi R, Kossenkov A, Schwartz L, Mills GB, Maity A, Lin LL, Simpkins F. Cancer. 2021 May 1. doi: 10.1002/cncr.33449.  PMID: 33932031
• Dichotomous and stable gamma delta T-cell number and function in healthy individuals.  Ou L, Wang H, Liu Q, Zhang J, Lu H, Luo L, Shi C, Lin S, Dong L, Guo Y, Huang L, Zhu J, Yin X, Huang AC, Karakousis G, Schuchter L, Amaravadi R, Zheng C, Fan Y, Guo W, Xu X. J Immunother Cancer. 2021 May;9(5):e002274. doi: 10.1136/jitc-2020-002274. PMID: 34011536
• Regulation of intercellular biomolecule transfer-driven tumor angiogenesis and responses to anticancer therapies.  Lu Z, Ortiz A, Verginadis II, Peck AR, Zahedi F, Cho C, Yu P, DeRita RM, Zhang H, Kubanoff R, Sun Y, Yaspan AT, Krespan E, Beiting DP, Radaelli E, Ryeom SW, Diehl JA, Rui H, Koumenis C, Fuchs SY. J Clin Invest. 2021 May 17;131(10):e144225. doi: 10.1172/JCI144225. PMID: 33998600
• Could Protons Promote Tumor Control by Avoiding Lymphopenia?  Deutsch E, Cengel KA, Galluzzi L, Levy A. J Thorac Oncol. 2021 Jun;16(6):e39-e41. doi: 10.1016/j.jtho.2021.01.1614. PMID: 34034888
• Determination of the distribution of drug concentration and tissue optical properties for ALA-mediated anal photodynamic therapy.  Ong YH, Li AC, Busch TM, Zhu TC. Proc SPIE Int Soc Opt Eng. 2021 Mar;11628:1162806. doi: 10.1117/12.2581824. Epub 2021 Mar 8. PMID: 34083860
• A Comparison of Two Probes to Determine Rectum Optical Properties.  Li AC, Ong YH, Li C, He J, Dimofte A, Busch TM, Wilson BC, Weersink R, Zhu TC. Proc SPIE Int Soc Opt Eng. 2021 Mar;11628:1162808. doi: 10.1117/12.2582395. Epub 2021 Mar 12. PMID: 34083859
• Cherenkov imaging for Total Skin Electron Therapy - an evaluation of dose uniformity.  Zhu TC, Ong Y, Sun H, Zhong W, Miao T, Dimofte A, Bruza P, Maity A, Plastaras JP, Paydar I, Dong L, Pogue BW. Proc SPIE Int Soc Opt Eng. 2021 Mar;11628:116280R. doi: 10.1117/12.2583939. Epub 2021 Mar 30. PMID: 34083857
• Synergistic immunotherapy of glioblastoma by dual targeting of IL-6 and CD40.

• Yang F, He Z, Duan H, Zhang D, Li J, Yang H, Dorsey JF, Zou W, Ali Nabavizadeh S, Bagley SJ, Abdullah K, Brem S, Zhang L, Xu X, Byrne KT, Vonderheide RH, Gong Y, Fan Y. Nat Commun. 2021 Jun 8;12(1):3424. doi: 10.1038/s41467-021-23832-3. PMID: 34103524

• NIR Fluorescent Imaging and Photodynamic Therapy with a Novel Theranostic Phospholipid Probe for Triple-Negative Breast Cancer Cells.  Rubtsova NI, Hart MC, Arroyo AD, Osharovich SA, Liebov BK, Miller J, Yuan M, Cochran JM, Chong S, Yodh AG, Busch TM, Delikatny EJ, Anikeeva N, Popov AV. Bioconjug Chem. 2021 Jun 17. doi: 10.1021/acs.bioconjchem.1c00295.  PMID: 34139845 

• Palliative Radiotherapy for Diffuse Large B-cell Lymphoma.  Wright CM, Koroulakis AI, Baron JA, Chong EA, Tseng YD, Kurtz G, LaRiviere M, Venigalla S, Jones JA, Maity A, Mohindra P, Plastaras JP, Paydar I. Clin Lymphoma Myeloma Leuk. 2021 May 19:S2152-2650(21)00194-4. doi: 10.1016/j.clml.2021.05.007.  PMID: 34127417 Review.

• Phase II Trial of Flaxseed to Prevent Acute Complications After Chemoradiation for Lung Cancer.  Lim TL, Pietrofesa RA, Arguiri E, Koumenis C, Feigenberg S, Simone CB, Rengan R, Cengel K, Levin WP, Christofidou-Solomidou M, Berman AT. J Altern Complement Med. 2021 Jun 23. doi: 10.1089/acm.2020.0542. Online ahead of print. PMID: 34161146 

• Report of AAPM Task Group 219 on independent calculation-based dose/MU verification for IMRT.  Zhu TC, Stathakis S, Clark JR, Feng W, Georg D, Holmes SM, Kry SF, Ma CC, Miften M, Mihailidis D, Moran JM, Papanikolaou N, Poppe B, Xiao Y. Med Phys. 2021 Jul 2. doi: 10.1002/mp.15069. Online ahead of print. PMID: 34213772

• Adjuvant Photodynamic Therapy, Mediated via Topical Versus Systemic Administration of 5-Aminolevulinic Acid for Control of Murine Mammary Tumor after Surgical Resection.  Carter S, Miller J, Cramer G, Yuan M, Guzman S, Putt ME, Cengel KA, Freedman GM, Busch TM. Photochem Photobiol. 2021 Jul 5. doi: 10.1111/php.13482. Online ahead of print. PMID: 34224156
• Brentuximab vedotin in combination with rituximab, cyclophosphamide, doxorubicin, and prednisone as frontline treatment for patients with CD30-positive B-cell lymphomas.  Svoboda J, Bair SM, Landsburg DJ, Dwivedy Nasta S, Nagle SJ, Barta SK, Khan N, Filicko-O'Hara J, Gaballa S, Strelec L, Chong E, Mitnick S, Waite TS, King C, Ballard H, Youngman M, Gerson J, Plastaras JP, Maity A, Bogusz AM, Hung SS, Nakamura H, Nejati R, Steidl C, Lim M, Ruella M, Schuster SJ. Haematologica. 2021 Jun 1;106(6):1705-1713. doi: 10.3324/haematol.2019.238675. PMID: 32414850
• Reduced eIF4E function impairs B-cell leukemia without altering normal B-lymphocyte function.  Chiu H, Buono R, Jackson LV, Herzog LO, Mallya S, Conn CS, Ruggero D, Fruman DA. iScience. 2021 Jun 17;24(7):102748. doi: 10.1016/j.isci.2021.102748. eCollection 2021 Jul 23. PMID: 34278258
• Low-Dose Radiotherapy Versus Moderate-Dose Radiotherapy for the Treatment of Indolent Orbital Adnexal Lymphomas.  Baron J, Wright CM, Lee DY, Carpenter M, Manjunath SH, Briceño CA, Chong E, Maity A, Plastaras JP, Paydar I. Front Oncol. 2021 Jul 5;11:716002. doi: 10.3389/fonc.2021.716002. eCollection 2021. PMID: 34290991
• Re: "A Computer Modeling Study of Water Radiolysis at High Dose Rates. Relevance to FLASH Radiotherapy." Ahmed Alanazi, Jintana Meesungnoem and Jean-Paul Gerin. Radiat Res 2021; 195:149-62.  Koch CJ. Radiat Res. 2021 Jul 14. doi: 10.1667/RADE-21-00124.1. PMID: 34260729
• FLASH proton radiotherapy spares normal epithelial and mesenchymal tissues while preserving sarcoma response.  Velalopoulou A, Karagounis IV, Cramer GM, Kim MM, Skoufos G, Goia D, Hagan S, Verginadis II, Shoniyozov K, Chiango J, Cerullo M, Varner K, Yao L, Qin L, Hatzigeorgiou AG, Minn AJ, Putt M, Lanza M, Assenmacher CA, Radaelli E, Huck J, Diffenderfer E, Dong L, Metz J, Koumenis C, Cengel KA, Maity A, Busch TM. Cancer Res. 2021 Jul 28:canres.1500.2021. doi: 10.1158/0008-5472.CAN-21-1500.  PMID: 34321243
• Thymic stromal lymphopoietin induces adipose loss through sebum hypersecretion.  Choa R, Tohyama J, Wada S, Meng H, Hu J, Okumura M, May RM, Robertson TF, Pai RL, Nace A, Hopkins C, Jacobsen EA, Haldar M, FitzGerald GA, Behrens EM, Minn AJ, Seale P, Cotsarelis G, Kim B, Seykora JT, Li M, Arany Z, Kambayashi T. Science. 2021 Jul 30;373(6554):eabd2893. doi: 10.1126/science.abd2893. PMID: 34326208
• Commentary: "Zooming in" on Glioblastoma: Understanding Tumor Heterogeneity and Its Clinical Implications in the Era of Single-Cell Ribonucleic Acid Sequencing.  Lucas A, Eberwine JH, Bagley SJ, Fan Y, Nasrallah M, Brem S. Neurosurgery. 2021 Jul 28:nyab280. doi: 10.1093/neuros/nyab280. Online ahead of print. PMID: 34318887
• Plasminogen regulates fracture repair by promoting the functions of periosteal mesenchymal progenitors.  Wang L, Yao L, Duan H, Yang F, Lin M, Zhang R, He Z, Ahn J, Fan Y, Qin L, Gong Y. J Bone Miner Res. 2021 Aug 11. doi: 10.1002/jbmr.4423.  PMID: 34378815
• Comparison of FLASH Proton Entrance and the Spread-Out Bragg Peak Dose Regions in the Sparing of Mouse Intestinal Crypts and in a Pancreatic Tumor Model.  Kim MM, Verginadis II, Goia D, Haertter A, Shoniyozov K, Zou W, Maity A, Busch TM, Metz JM, Cengel KA, Dong L, Koumenis C, Diffenderfer ES. Cancers (Basel). 2021 Aug 23;13(16):4244. doi: 10.3390/cancers13164244. PMID: 34439398
• The immunostimulatory RNA RN7SL1 enables CAR-T cells to enhance autonomous and endogenous immune function.  Johnson LR, Lee DY, Eacret JS, Ye D, June CH, Minn AJ. Cell. 2021 Aug 26:S0092-8674(21)00946-6. doi: 10.1016/j.cell.2021.08.004. PMID: 34464586
• Cell plasticity, senescence, and quiescence in cancer stem cells: Biological and therapeutic implications.  Paul R, Dorsey JF, Fan Y. Pharmacol Ther. 2021 Sep 1:107985. doi: 10.1016/j.pharmthera.2021.107985. PMID: 34480963 Review.
• Friedberg JS, Simone CB 2nd, Culligan MJ, Putt ME, Barsky AR, Katz S, Cengel KA. Posterior Intercostal Lymph Nodes Double Recurrence and Death Risk in Malignant Pleural Mesothelioma. Ann Thorac Surg. 2019 Oct 18. pii: S0003-4975(19)31588-7. doi: 10.1016/j.athoracsur.2019.07.097. PMID: 31634442
• Xie Y, Petroccia H, Maity A, Miao T, Zhu Y, Bruza P, Pogue BW, Plastaras JP, Dong L, Zhu TC. Cherenkov imaging for Total Skin Electron Therapy (TSET).  Med Phys. 2019 Oct 30. PMID: 31665544
• Louneva N, Maity A, Kennedy AR. Plasma D-Dimer Levels are Elevated in Radiation Oncology Patients. Radiat Res. 2019 Nov PMID: 31675265
• Yan L, Luo L, Amirshaghaghi A, Miller J, Meng C, You T, Busch TM, Tsourkas A, Cheng Z. Dextran-Benzoporphyrin Derivative (BPD) Coated Superparamagnetic Iron Oxide Nanoparticle (SPION) Micelles for T₂-Weighted Magnetic Resonance Imaging and Photodynamic Therapy. Bioconjug Chem. 2019 Nov 8. PMID: 31661959
• Ong YH, Dimofte A, Kim MM, Finlay JC, Sheng T, Singhal S, Cengel KA, Yodh AG, Busch TM, Zhu TC. Reactive Oxygen Species Explicit Dosimetry for Photofrin-mediated Pleural Photodynamic Therapy. Photochem Photobiol. 2019 Nov 1 PMID: 31729774
• Penjweini R, Kim MM, Ong YH, Zhu TC.¹ O ₂ determined from the measured PDT dose and ³ O ₂ predicts long-term response to Photofrin-mediated PDT. Phys Med Biol. 2019 Nov 21. PMID: 31751964
• Makhlin I, Salinas RD, Zhang D, Jacob F, Ming GL, Song H, Saxena D, Dorsey JF, Nasrallah MP, Morrissette JJ, Binder ZA, O'Rourke DM, Desai AS, Brem S, Bagley SJ. Clinical activity of the EGFR tyrosine kinase inhibitor osimertinib in EGFR-mutant glioblastoma. CNS Oncol. 2019 Nov 1;8(3):CNS43. PMID: 31769726
• Saxena D, Sheikh S, Kao G, Binder ZA, Alonso-Basanta M, O'Rourke DM, Nasrallah MP, Dorsey JF.
  Rapid and ultrasensitive digital PCR (dPCR) profiling of EGFRvIII in tumor cells and tissues. Neurooncol Adv. 2019 May-Dec;1(1):vdz030. PMID: 31807732
• Uribe-Herranz M, Rafail S, Beghi S, Gil-de-Gómez L, Verginadis I, Bittinger K, Pustylnikov S, Pierini S, Perales-Linares R, Blair IA, Mesaros CA, Snyder NW, Bushman F, Koumenis C, Facciabene A. Gut microbiota modulate dendritic cell antigen presentation and radiotherapy-induced antitumor immune response. J Clin Invest. 2019 Dec PMID: 31815742
• Bhardwaj M, Leli NM, Koumenis C, Amaravadi RK. Regulation of autophagy by canonical and non-canonical ER stress responses. Semin Cancer Biol. 2019 Dec 12. PMID: 31838023
• Namoglu EC, Hughes ME, Plastaras JP, Landsburg DJ, Maity A, Nasta SD. Management and outcomes of sinus histiocytosis with massive lymphadenopathy (Rosai Dorfman Disease). Leuk Lymphoma. 2019 Dec 26:1-7. PMID: 31876204
• Jacob F, Salinas RD, Zhang DY, Nguyen PTT, Schnoll JG, Wong SZH, Thokala R, Sheikh S, Saxena D, Prokop S, Liu DA, Qian X, Petrov D, Lucas T, Chen HI, Dorsey JF, Christian KM, Binder ZA, Nasrallah M, Brem S, O'Rourke DM, Ming GL, Song H. A Patient-Derived Glioblastoma Organoid Model and Biobank Recapitulates Inter- and Intra-tumoral Heterogeneity. Cell. 2019 Dec 23. pii: S0092-8674(19)31321-2. PMID: 31883794
• Diffenderfer ES, Verginadis II, Kim MM, Shoniyozov K, Velalopoulou A, Goia D, Putt M, Hagan S, Avery S, Teo K, Zou W, Lin A, Swisher-McClure S, Koch C, Kennedy AR, Minn A, Maity A, Busch TM, Dong L, Koumenis C, Metz J, Cengel KA. Design, Implementation, and in Vivo Validation of a Novel Proton FLASH Radiation Therapy System. Int J Radiat Oncol Biol Phys. 2020 Feb 1;106(2):440-448. PMID: 31928642
• Frick MA, Feigenberg SJ, Jean-Baptiste SR, Aguarin LA, Mendes A, Chinniah C, Swisher-McClure S, Berman A, Levin W, Cengel K, Hahn SM, Dorsey JF, Simone CB, Kao GD.  Circulating tumor cells are associated with recurrent disease in patients with early stage non-small cell lung cancer treated with stereotactic body radiation therapy. Clin Cancer Res. 2020 Jan 22. PMID: 31969332
• Zhao H, Xie L, Clemens JL, Zong L, McLane MW, Arif H, Feller MC, Jia B, Zhu Y, Facciabene A, Ozen M, Lei J, Burd I. Mouse Bone Marrow-Derived Mesenchymal Stem Cells Alleviate Perinatal Brain Injury Via a CD8 ⁺ T Cell Mechanism in a Model of Intrauterine Inflammation. Reprod Sci. 2020 Jan 29. PMID: 31997258
• Cramer GM, Sandell Meo J, Finlay JC, Zhu TC, Busch TM, Cengel KA. In vivo Spectroscopic Evaluation of the Intraperitoneal Cavity in Canines. Photochem Photobiol. 2020 Feb 14. PMID: 32060914
• Kim MM, Zhu TC, Ong YH, Finlay JC, Dimofte A, Singhal S, Glatstein E, Cengel KA. Infrared navigation system for light dosimetry during pleural photodynamic therapy. Phys Med Biol. 2020 Feb 13. PMID: 32053799
• Dupre PJ, Ong YH, Friedberg J, Singhal S, Carter S, Simone CB 2nd, Finlay JC, Zhu TC, Cengel KA, Busch TM. Light Fluence Rate and Tissue Oxygenation (S _t O ₂ ) Distributions Within the Thoracic Cavity of Patients Receiving Intraoperative
  Photodynamic Therapy for Malignant Pleural Mesothelioma. Photochem Photobiol. 2020 Feb 12. PMID: 32048732
• Huang M, Zhang D, Wu JY, Xing K, Yeo E, Li C, Zhang L, Holland E, Yao L, Qin L, Binder ZA, O'Rourke DM, Brem S, Koumenis C, Gong Y, Fan Y. Wnt-mediated endothelial transformation into mesenchymal stem cell-like cells induces chemoresistance in glioblastoma. Sci Transl Med. 2020 Feb 26;12(532). PMID: 32102932
• Cramer G, Lewis R, Gymarty A, Hagan S, Mickler M, Evans S, Punekar SR, Shuman L, Simone CB 2nd, Hahn SM, Busch TM, Fraker D, Cengel KA. Preclinical Evaluation of Cetuximab and Benzoporphyrin Derivative-Mediated Intraperitoneal Photodynamic Therapy in a Canine Model. Photochem Photobiol. 2020 Mar 2. PMID: 32119123
• Mohiuddin JJ, Chu B, Facciabene A, Poirier K, Wang X, Doucette A, Zheng C, Xu W, Anstadt EJ, Amaravadi RK, Karakousis GC, Mitchell TC, Huang AC, Shabason JE, Lin A, Swisher-McClure S, Maity A, Schuchter LM, Lukens JN. Association of antibiotic exposure with survival and toxicity in patients with melanoma receiving immunotherapy. J Natl Cancer Inst. 2020 Apr 15. pii: djaa057. doi: 10.1093/jnci/djaa057. PMID: 32294209
• Busch TM, Cengel KA, Zhu TC. In Memoriam Jarod C. Finlay, PhD. Photochem Photobiol. 2020 Mar;96(2):218. PMID: 32249478
• Luna JM, Chao HH, Shinohara RT, Ungar LH, Cengel KA, Pryma DA, Chinniah C, Berman AT, Katz SI, Kontos D, Simone CB 2nd, Diffenderfer ES. Machine learning highlights the deficiency of conventional dosimetric constraints for prevention of high-grade radiation esophagitis in non-small cell lung cancer treated with chemoradiation. Clin Transl Radiat Oncol. 2020 Mar 24;22:69-75. doi: 10.1016/j.ctro.2020.0007. PMID: 32274426
• Chao HH, Karagounis IV, Thomas C, François NB, Facciabene A, Koumenis C, Maity A. Combination of CHEK1/2 inhibition and ionizing radiation results in abscopal tumor response through increased micronuclei formation. Oncogene. 2020 Apr 25. PMID: 32335582.
• Barsky AR, Kim MM, Williams GR, Lally BE, Ingram WS, Cengel KA, Feigenberg SJ. Proton-beam therapy: at the heart of cardiac dose-sparing in mediastinal radiotherapy for thymic carcinoma. J Thorac Oncol. 2020 Apr 27. PMID: 32353600
• Luo LY, O'Hara MH, Mitchell TC, Vonderheide RH, Wherry EJ, Minn AJ, Maity A. Combining Radiation with Immunotherapy: The University of Pennsylvania Experience. Semin Radiat Oncol. 2020 Apr;30(2):173-180. PMID: 32381296
• Jain V, Niezink AGH, Frick M, Doucette A, Mendes A, Simone CB 2nd, Langendijk JA, Wijsman R, Feigenberg SJ, Levin W, Cengel KA, van der Schaaf A, Berman AT. Updating Photon-based Normal Tissue Complication Probability Models for Pneumonitis in Lung Cancer Patients Treated with Proton Beam Therapy. Pract Radiat Oncol. 2020 May 13. PMID: 32416270
• Carabe-Fernandez A, Karagounis I, Huynh K, Bertolet A, François N, Kim MM, Maity A, Abel E, Dale RG. Radiobiological effectiveness difference of proton arc beams versus conventional proton and photon beams. Phys Med Biol. 2020 May 15. PMID: 32413889
• Svoboda J, Bair SM, Landsburg DJ, Nasta SD, Nagle SJ, Barta SK, Khan N, Filicko-O'Hara J, Gaballa S, Strelec L, Chong E, Mitnick S, Waite TS, King C, Ballard H, Youngman M, Gerson J, Plastaras JP, Maity A, Bogusz AM, Hung SS, Nakamura H, Nejati R, Steidl C, Lim M, Ruella M, Schuster SJ. Brentuximab vedotin in combination with rituximab, cyclophosphamide, doxorubicin, and prednisone as frontline treatment for patients with CD30-positive B-cell lymphomas. Haematologica. 2020 May 15. PMID: 32414850
• Wright CM, LaRiviere MJ, Baron JA, Uche C, Xiao Y, Arscott WT, Anstadt EJ, Barsky AR, Miller D, LaRose MI, Landsburg DJ, Svoboda J, Nasta SD, Gerson JN, Barta SK, Chong EA, Schuster SJ, Paydar I, Maity A, Plastaras JP. Bridging Radiation Therapy Prior to Commercial Chimeric Antigen Receptor T-Cell Therapy for relapsed/refractory aggressive B-cell lymphoma. Int J Radiat Oncol Biol Phys. 2020 May 21. PMID: 32446950
• Cramer GM, Moon EK, Cengel KA, Busch TM. Photodynamic Therapy and Immune Checkpoint Blockade. Photochem Photobiol. 2020 Jun 23. PMID: 32573787
• Ong YH, Miller J, Yuan M, Chandra M, El Khatib M, Vinogradov SA, Putt ME, Zhu TC, Cengel KA, Yodh AG, Busch TM. Blood Flow Measurements Enable Optimization of Light Delivery for Personalized Photodynamic Therapy. Cancers (Basel). 2020 Jun 15;12(6). PMID: 32549354
• Miao T, Petroccia H, Xie Y, Jermyn M, Perroni-Scharf M, Kapoor N, Mahoney JM, Zhu TC, Bruza P, Williams BB, Gladstone DJ, Pogue BW. Computer animation body surface analysis of total skin electron radiation therapy dose homogeneity via Cherenkov imaging. J Med Imaging (Bellingham). 2020 May;7(3):034002. PMID: 32509916
• Barsky AR, Ahern CA, Venigalla S, Verma V, Anstadt EJ, Wright CM, Ludmir EB, Berlind CG, Lindsay WD, Grover S, Cengel KA, Simone CB 2nd. Gender-based Disparities in Receipt of Care and Survival in Malignant Pleural Mesothelioma. Clin Lung Cancer. 2020 May 23. pii: S1525-7304(20)30161-3. PMID: 32611504
• Beeson KW, Parilov E, Potasek M, Kim MM, Zhu TC. Validation of combined Monte Carlo and photokinetic simulations for the outcome correlation analysis of benzoporphyrin derivative-mediated photodynamic therapy on mice. J Biomed Opt. 2019 Mar;24(3):1-9. PMID: 30873764
• Duan H, He Z, Lin M, Wang Y, Yang F, Mitteer RA, Kim HJ, Yeo E, Han H, Qin L, Fan Y, Gong Y. Plasminogen regulates mesenchymal stem cell-mediated tissue repair after ischemia through Cyr61 activation. JCI Insight. 2020 Aug 6;5(15):131376. doi: 10.1172/jci.insight.131376. PMID: 32759492
• Patel A, Roshkovan L, McNulty S, Alley E, Torigian DA, Nachiappan AC, Galperin-Aizenberg M, Barbosa EM Jr, DiRienzi J, Berger I, Khalid U, Haas AR, Singhal S, Wileyto EP, Cengel KA, Katz SI. Delayed-Phase Enhancement for Evaluation of Malignant Pleural Mesothelioma on Computed Tomography: A Prospective Cohort Study. Clin Lung Cancer. 2020 Jun 14:S1525-7304(20)30184-4. doi: 10.1016/j.cllc.2020.06.002. Online ahead of print. PMID: 32693945
• Russell KL, Gorgulho CM, Allen A, Vakaki M, Wang Y, Facciabene A, Lee D, Roy P, Buchser WJ, Appleman LJ, Maranchie J, Storkus WJ, Lotze MT. Inhibiting Autophagy in Renal Cell Cancer and the Associated Tumor Endothelium. Cancer J. 2019 May/Jun;25(3):165-177. doi: 10.1097/PPO.0000000000000374. Review. PMID: 31135523
• Evaluation of Light Fluence Distribution Using an IR Navigation System for HPPH-mediated Pleural Photodynamic Therapy (pPDT). Zhu TC, Ong Y, Kim MM, Liang X, Finlay JC, Dimofte A, Simone Nd CB, Friedberg JS, Busch TM, Glatstein E, Cengel KA. Photochem Photobiol. 2019 Sep 25. doi: 10.1111/php.13166. PMID:31556122
• Acute neurologic toxicity of palliative radiotherapy for brain metastases in patients receiving immune checkpoint blockade. Arscott WT, Zhu S, Plastaras JP, Maity A, Alonso-Basanta M, Jones J. Neurooncol Pract. 2019 Jul;6(4):297-304. doi: 10.1093/nop/npy042. Epub 2018 Oct 25. PMID:31386046
• Opposing Functions of Interferon Coordinate Adaptive and Innate Immune Responses to Cancer Immune Checkpoint Blockade. Benci JL, Johnson LR, Choa R, Xu Y, Qiu J, Zhou Z, Xu B, Ye D, Nathanson KL, June CH, Wherry EJ, Zhang NR, Ishwaran H, Hellmann MD, Wolchok JD, Kambayashi T, Minn AJ. Cell. 2019 Aug 8;178(4):933-948.e14. doi: 10.1016/j.cell.2019.07.019. PMID:31398344
• Clinical Outcomes of the HIV Protease Inhibitor Nelfinavir With Concurrent Chemoradiotherapy for Unresectable Stage IIIA/IIIB Non-Small Cell Lung Cancer: A Phase 1/2 Trial. Rengan R, Mick R, Pryma DA, Lin LL, Christodouleas J, Plastaras JP, Simone CB 2nd, Gupta AK, Evans TL, Stevenson JP, Langer CJ, Kucharczuk J, Friedberg J, Lam S, Patsch D, Hahn SM, Maity A. JAMA Oncol. 2019 Aug 22. doi: 10.1001/jamaoncol.2019.2095. PMID:31436839
• Vascular Detransformation for Cancer Therapy. Fan Y. Trends Cancer. 2019 Aug;5(8):460-463. doi: 10.1016/j.trecan.2019.05.007. Epub 2019 Jun 14. PMID:31421902
• Phenotypic and functional analysis of malignant mesothelioma tumor-infiltrating lymphocytes. Klampatsa A, O'Brien SM, Thompson JC, Rao AS, Stadanlick JE, Martinez MC, Liousia M, Cantu E, Cengel K, Moon EK, Singhal S, Eruslanov EB, Albelda SM. Oncoimmunology. 2019 Jul 13;8(9):e1638211. doi: 10.1080/2162402X.2019.1638211. eCollection 2019. PMID:31428531
• Re: Differential impact of FLASH versus conventional dose rate irradiation: Spitz et al. Koch CJ. Radiother Oncol. 2019 Oct;139:62-63. doi: 10.1016/j.radonc.2019.07.004. Epub 2019 Aug 17. PMID:31431380
• Early Detection of Recurrence in Patients With Locally Advanced Non-Small-Cell Lung Cancer via Circulating Tumor Cell Analysis.Chinniah C, Aguarin L, Cheng P, Decesaris C, Cutillo A, Berman AT, Frick M, Doucette A, Cengel KA, Levin W, Hahn S, Dorsey JF, Simone CB 2nd, Kao GD. Clin Lung Cancer. 2019 Sep;20(5):384-390.e2. doi: 10.1016/j.cllc.2019.04.011. Epub 2019 May 4.  PMID:31221522
• Intratumoral Hypoxia Reduces IFN-γ-Mediated Immunity and MHC Class I Induction in a Preclinical Tumor Model. Murthy A, Gerber SA, Koch CJ, Lord EM. Immunohorizons. 2019 Apr 29;3(4):149-160. doi: 10.4049/immunohorizons.1900017. PMID:31356176
• Reactive oxygen species explicit dosimetry to predict local tumor control for Photofrin-mediated photodynamic therapy. Sheng T, Ong YH, Busch TM, Zhu TC. Proc SPIE Int Soc Opt Eng. 2019 Feb;10860. pii: 108600V. doi: 10.1117/12.2508803. Epub 2019 Mar 12.  PMID:31327886
• Reactive oxygen species explicit dosimetry to predict tumor growth for BPD-mediated vascular photodynamic therapy. Sheng T, Ong YH, Busch TM, Zhu TC. Proc SPIE Int Soc Opt Eng. 2019 Feb;10861. pii: 108610A. doi: 10.1117/12.2514657. Epub 2019 Mar 7.  PMID:31080306
• Cooperation between Constitutive and Inducible Chemokines Enables T Cell Engraftment and Immune Attack in Solid Tumors. Dangaj D, Bruand M, Grimm AJ, Ronet C, Barras D, Duttagupta PA, Lanitis E, Duraiswamy J, Tanyi JL, Benencia F, Conejo-Garcia J, Ramay HR, Montone KT, Powell DJ Jr, Gimotty PA, Facciabene A, Jackson DG, Weber JS, Rodig SJ, Hodi SF, Kandalaft LE, Irving M, Zhang L, Foukas P, Rusakiewicz S, Delorenzi M, Coukos G. Cancer Cell. 2019 Jun 10;35(6):885-900.e10. doi: 10.1016/j.ccell.2019.05.004.  PMID:31185212
• ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumour progression.  Tameire F, Verginadis II, Leli NM, Polte C, Conn CS, Ojha R, Salinas CS, Chinga F, Monroy AM, Fu W, Wang P, Kossenkov A, Ye J, Amaravadi RK, Ignatova Z, Fuchs SY, Diehl JA, Ruggero D, Koumenis C. Nat Cell Biol. 2019 Aug;21(8):1052. doi: 10.1038/s41556-019-0370-x. PMID:31316187
• Predicting radiation pneumonitis in locally advanced stage II-III non-small cell lung cancer using machine learning. Luna JM, Chao HH, Diffenderfer ES, Valdes G, Chinniah C, Ma G, Cengel KA, Solberg TD, Berman AT, Simone CB 2nd. Radiother Oncol. 2019 Apr;133:106-112. doi: 10.1016/j.radonc.2019.01.003. Epub 2019 Jan 23. PMID:30935565
• Important Technical Considerations for Implementing the ASTRO/ASCO/AUA Prostate Cancer Hypofractionated Radiation Guideline. LaRiviere MJ, Zhu TC, Christodouleas JP. Pract Radiat Oncol. 2019 Jul - Aug;9(4):197-199. doi: 10.1016/j.prro.2019.02.017. Epub 2019 Mar 2. No abstract available. PMID:30836189
• Validation of combined Monte Carlo and photokinetic simulations for the outcome correlation analysis of benzoporphyrin derivative-mediated photodynamic therapy on mice. Beeson KW, Parilov E, Potasek M, Kim MM, Zhu TC. J Biomed Opt. 2019 Mar;24(3):1-9. doi: 10.1117/1.JBO.24.3.035006. PMID:30873764
• The PKR-Like Endoplasmic Reticulum Kinase Promotes the Dissemination of Myc-Induced Leukemic Cells. Gui J, Katlinski KV, Koumenis C, Diehl JA, Fuchs SY. Mol Cancer Res. 2019 Jul;17(7):1450-1458. doi: 10.1158/1541-7786.MCR-19-0002. Epub 2019 Mar 22. PMID:30902831
• Genomic characterization of genes encoding histone acetylation modulator proteins identifies therapeutic targets for cancer treatment. Hu Z, Zhou J, Jiang J, Yuan J, Zhang Y, Wei X, Loo N, Wang Y, Pan Y, Zhang T, Zhong X, Long M, Montone KT, Tanyi JL, Fan Y, Wang TL, Shih IM, Hu X, Zhang L. Nat Commun. 2019 Feb 13;10(1):733. doi: 10.1038/s41467-019-08554-x. PMID:30760718
• Chlorin e6-Coated Superparamagnetic Iron Oxide Nanoparticle (SPION) Nanoclusters as a Theranostic Agent for Dual-Mode Imaging and Photodynamic Therapy. Amirshaghaghi A, Yan L, Miller J, Daniel Y, Stein JM, Busch TM, Cheng Z, Tsourkas A. Sci Rep. 2019 Feb 22;9(1):2613. doi: 10.1038/s41598-019-39036-1. PMID:30796251
• 5-aminolevulinic acid photodynamic therapy for the treatment of high-grade gliomas. Mahmoudi K, Garvey KL, Bouras A, Cramer G, Stepp H, Jesu Raj JG, Bozec D, Busch TM, Hadjipanayis CG. J Neurooncol. 2019 Feb;141(3):595-607. doi: 10.1007/s11060-019-03103-4. Epub 2019 Jan 18. Review. PMID:30659522
• Precision Cardio-Oncology. Dreyfuss AD, Bravo PE, Koumenis C, Ky B. J Nucl Med. 2019 Apr;60(4):443-450. doi: 10.2967/jnumed.118.220137. Epub 2019 Jan 17. PMID:30655328
• An Interferon-Driven Oxysterol-Based Defense against Tumor-Derived Extracellular Vesicles. Ortiz A, Gui J, Zahedi F, Yu P, Cho C, Bhattacharya S, Carbone CJ, Yu Q, Katlinski KV, Katlinskaya YV, Handa S, Haas V, Volk SW, Brice AK, Wals K, Matheson NJ, Antrobus R, Ludwig S, Whiteside TL, Sander C, Tarhini AA, Kirkwood JM, Lehner PJ, Guo W, Rui H, Minn AJ, Koumenis C, Diehl JA, Fuchs SY. Cancer Cell. 2019 Jan 14;35(1):33-45.e6. doi: 10.1016/j.ccell.2018.12.001. PMID:30645975
• An Integrated Stress Response Agent that Modulates DR5-Dependent TRAIL Synergy Reduces Patient-Derived Glioma Stem Cell Viability. Sheikh S, Saxena D, Tian X, Amirshaghaghi A, Tsourkas A, Brem S, Dorsey JF. Mol Cancer Res. 2019 May;17(5):1102-1114. doi: 10.1158/1541-7786.MCR-18-0276. Epub 2019 Jan 14. PMID:30642878
• LGM2605 Reduces Space Radiation-Induced NLRP3 Inflammasome Activation and Damage in In Vitro Lung Vascular Networks. Chatterjee S, Pietrofesa RA, Park K, Tao JQ, Carabe-Fernandez A, Berman AT, Koumenis C, Sielecki T, Christofidou-Solomidou M. Int J Mol Sci. 2019 Jan 5;20(1). pii: E176. doi: 10.3390/ijms20010176. PMID:30621290
• ER Translocation of the MAPK Pathway Drives Therapy Resistance in BRAF-Mutant Melanoma. Ojha R, Leli NM, Onorati A, Piao S, Verginadis II, Tameire F, Rebecca VW, Chude CI, Murugan S, Fennelly C, Noguera-Ortega E, Chu CT, Liu S, Xu X, Krepler C, Xiao M, Xu W, Wei Z, Frederick DT, Boland G, Mitchell TC, Karakousis GC, Schuchter LM, Flaherty KT, Zhang G, Herlyn M, Koumenis C, Amaravadi RK. Cancer Discov. 2019 Mar;9(3):396-415. doi: 10.1158/2159-8290.CD-18-0348. Epub 2018 Dec 18. Erratum in: Cancer Discov. 2019 Jul;9(7):981. PMID:30563872
• Modeling Epidermal Growth Factor Inhibitor-mediated Enhancement of Photodynamic Therapy Efficacy Using 3D Mesothelioma Cell Culture. Cramer G, Shin M, Hagan S, Katz SI, Simone CB 2nd, Busch TM, Cengel KA. Photochem Photobiol. 2019 Jan;95(1):397-405. doi: 10.1111/php.13067. Epub 2019 Jan 7. PMID:30499112
• A Novel Prospective Study Assessing the Combination of Photodynamic Therapy and Proton Radiation Therapy: Safety and Outcomes When Treating Malignant Pleural Mesothelioma. Rice SR, Li YR, Busch TM, Kim MM, McNulty S, Dimofte A, Zhu TC, Cengel KA, Simone CB 2nd. Photochem Photobiol. 2019 Jan;95(1):411-418. doi: 10.1111/php.13065. Epub 2018 Dec 28. PMID:30485442
• Early Changes in Cardiovascular Biomarkers with Contemporary Thoracic Radiation Therapy for Breast Cancer, Lung Cancer, and Lymphoma. Demissei BG, Freedman G, Feigenberg SJ, Plastaras JP, Maity A, Smith AM, McDonald C, Sheline K, Simone CB 2nd, Lin LL, Carver JR, Liu P, Zhang L, Bekelman JE, Ky B. Int J Radiat Oncol Biol Phys. 2019 Mar 15;103(4):851-860. doi: 10.1016/j.ijrobp.2018.11.013. Epub 2018 Nov 14. PMID:30445173
• YAP1 enhances NF-κB-dependent and independent effects on clock-mediated unfolded protein responses and autophagy in sarcoma.Rivera-Reyes A, Ye S, E Marino G, Egolf S, E Ciotti G, Chor S, Liu Y, Posimo JM, Park PMC, Pak K, Babichev Y, Sostre-Colón J, Tameire F, Leli NM, Koumenis C, C Brady D, Mancuso A, Weber K, Gladdy R, Qi J, Eisinger-Mathason TSK. Cell Death Dis. 2018 Oct 31;9(11):1108. doi: 10.1038/s41419-018-1142-4. PMID:30382078
• Luminol Chemiluminescence Reports Photodynamic Therapy-Generated Neutrophil Activity In Vivo and Serves as a Biomarker of Therapeutic Efficacy. Davis RW 4th, Snyder E, Miller J, Carter S, Houser C, Klampatsa A, Albelda SM, Cengel KA, Busch TM. Photochem Photobiol. 2019 Jan;95(1):430-438. doi: 10.1111/php.13040. Epub 2018 Nov 26. PMID:30357853
• Inhibiting Autophagy in Renal Cell Cancer and the Associated Tumor Endothelium. Russell KL, Gorgulho CM, Allen A, Vakaki M, Wang Y, Facciabene A, Lee D, Roy P, Buchser WJ, Appleman LJ, Maranchie J, Storkus WJ, Lotze MT. Cancer J. 2019 May/Jun;25(3):165-177. doi: 10.1097/PPO.0000000000000374. PMID:31135523
• Toward a comprehensive view of cancer immune responsiveness: a synopsis from the SITC workshop. Bedognetti D, Ceccarelli M, Galluzzi L, Lu R, Palucka K, Samayoa J, Spranger S, Warren S, Wong KK, Ziv E, Chowell D, Coussens LM, De Carvalho DD, DeNardo DG, Galon J, Kaufman HL, Kirchhoff T, Lotze MT, Luke JJ, Minn AJ, Politi K, Shultz LD, Simon R, Thórsson V, Weidhaas JB, Ascierto ML, Ascierto PA, Barnes JM, Barsan V, Bommareddy PK, Bot A, Church SE, Ciliberto G, De Maria A, Draganov D, Ho WS, McGee HM, Monette A, Murphy JF, Nisticò P, Park W, Patel M, Quigley M, Radvanyi L, Raftopoulos H, Rudqvist NP, Snyder A, Sweis RF, Valpione S, Zappasodi R, Butterfield LH, Disis ML, Fox BA, Cesano A, Marincola FM; Society for Immunotherapy of Cancer (SITC) Cancer Immune Responsiveness Task Force and Working Groups. J Immunother Cancer. 2019 May 22;7(1):131. doi: 10.1186/s40425-019-0602-4. Review. Erratum in: J Immunother Cancer. 2019 Jul 4;7(1):167. PMID:31113486
• A prospective clinical trial of proton therapy for chordoma and chondrosarcoma: Feasibility assessment. Baumann BC, Lustig RA, Mazzoni S, Grady SM, O'Malley BW, Lee JYK, Newman JG, Schuster JM, Both S, Lin A, Dorsey JF, Alonso-Basanta M. J Surg Oncol. 2019 Aug;120(2):200-205. doi: 10.1002/jso.25502. Epub 2019 May 20. PMID:31111502
• Lymphangitic carcinomatosis: A common radiographic manifestation of local failure following extended pleurectomy/decortication in patients with malignant pleural mesothelioma. Berger I, Cengel KA, Simone CB 2nd, Alley EW, Roshkovan L, Haas AR, Patel AM, Khalid U, Culligan MJ, McNulty S, Singhal S, Friedberg JS, Katz SI. Lung Cancer. 2019 Jun;132:94-98. doi: 10.1016/j.lungcan.2019.03.026. Epub 2019 Mar 26. PMID:31097101
• Design and commissioning of an image-guided small animal radiation platform and quality assurance protocol for integrated proton and x-ray radiobiology research. Kim MM, Irmen P, Shoniyozov K, Verginadis II, Cengel KA, Koumenis C, Metz JM, Dong L, Diffenderfer ES. Phys Med Biol. 2019 Jul 4;64(13):135013. doi: 10.1088/1361-6560/ab20d9. PMID:31075786
• 5-aminolevulinic acid photodynamic therapy for the treatment of high-grade gliomas. Mahmoudi K, Garvey KL, Bouras A, Cramer G, Stepp H, Jesu Raj JG, Bozec D, Busch TM, Hadjipanayis CG. J Neurooncol. 2019 Feb;141(3):595-607. doi: 10.1007/s11060-019-03103-4. Epub 2019 Jan 18. Review.  PMID:3065952
• Assessing the Validity of Clinician Advice That Patients Avoid Use of Topical Agents Before Daily Radiotherapy Treatments. Baumann BC, Verginadis II, Zeng C, Bell B, Koduri S, Vachani C, MacArthur KM, Solberg TD, Koumenis C, Metz JM. JAMA Oncol. 2018 Oct 18. doi: 10.1001/jamaoncol.2018.4292. PMID:30347008
• Five-year Long-term Outcomes of Stereotactic Body Radiation Therapy for Operable Versus Medically Inoperable Stage I Non-small-cell Lung Cancer: Analysis by Operability, Fractionation Regimen, Tumor Size, and Tumor Location. Schonewolf CA, Heskel M, Doucette A, Singhal S, Frick MA, Xanthopoulos EP, Corradetti MN, Friedberg JS, Pechet TT, Christodouleas JP, Levin W, Berman A, Cengel KA, Verma V, Hahn SM, Kucharczuk JC, Rengan R, Simone CB 2nd. Clin Lung Cancer. 2018 Sep 20. pii: S1525-7304(18)30237-7. doi: 10.1016/j.cllc.2018.09.004. PMID:30337269
• Interleukin-6 signaling blockade exacerbates acute and late injury from focal intestinal irradiation. Bell BI, Koduri S, Salinas CS, Monslow J, Puré E, Ben-Josef E, Koumenis C, Verginadis II. Int J Radiat Oncol Biol Phys. 2018 Oct 15. pii: S0360-3016(18)33858-6. doi: 10.1016/j.ijrobp.2018.10.007. PMID:30336264
• Circulating glioma cells exhibit stem cell-like properties. Liu T, Xu H, Huang M, Ma W, Saxena D, Lustig RA, Alonso-Basanta M, Zhang Z, O Rourke DM, Zhang L, Gong Y, Kao GD, Dorsey JF, Fan Y. Cancer Res. 2018 Oct 15. pii: canres.0650.2018. doi: 10.1158/0008-5472.CAN-18-0650. PMID:30322863
• A phase I trial of pembrolizumab with hypofractionated radiotherapy in patients with metastatic solid tumours. Maity A, Mick R, Huang AC, George SM, Farwell MD, Lukens JN, Berman AT, Mitchell TC, Bauml J, Schuchter LM, O'Hara M, Lin LL, Demichele A, Christodouleas JP, Haas NB, Patsch DM, Hahn SM, Minn AJ, Wherry EJ, Vonderheide RH. Br J Cancer. 2018 Oct 15.  PMID:30318516
• Integrated Analysis of Genetic Ancestry and Genomic Alterations across Cancers. Yuan J, Hu Z, Mahal BA, Zhao SD, Kensler KH, Pi J, Hu X, Zhang Y, Wang Y, Jiang J, Li C, Zhong X, Montone KT, Guan G, Tanyi JL, Fan Y, Xu X, Morgan MA, Long M, Zhang Y, Zhang R, Sood AK, Rebbeck TR, Dang CV, Zhang L. Cancer Cell. 2018 Oct 8;34(4):549-560.e9. doi: 10.1016/j.ccell.2018.08.019. PMID:30300578
• Circulating Tumor Cell Assessment in Presumed Early Stage Non-Small Cell Lung Cancer Patients Treated with Stereotactic Body Radiation Therapy: A Prospective Pilot Study. Frick MA, Kao GD, Aguarin L, Chinniah C, Swisher-McClure S, Berman AT, Levin WP, Cengel KA, DeCesaris C, Hahn SM, Dorsey JF, Simone CB 2nd. Int J Radiat Oncol Biol Phys. 2018 Nov 1;102(3):536-542. doi: 10.1016/j.ijrobp.2018.06.041. Epub 2018 Jul 2. PMID:30244877
• Adjuvant, neoadjuvant, and definitive radiation therapy for malignant pleural mesothelioma. Cramer G, Simone CB 2nd, Busch TM, Cengel KA. J Thorac Dis. 2018 Aug;10(Suppl 21):S2565-S2573. doi: 10.21037/jtd.2018.07.65. Review. PMID:30206500
• RNA-binding protein LIN28B inhibits apoptosis through regulation of the AKT2/FOXO3A/BIM axis in ovarian cancer cells. Lin X, Shen J, Dan Peng, He X, Xu C, Chen X, Tanyi JL, Montone K, Fan Y, Huang Q, Zhang L, Zhong X. Signal Transduct Target Ther. 2018 Aug 31;3:23. doi: 10.1038/s41392-018-0026-5. eCollection 2018. PMID:30174831
• PDGF-mediated mesenchymal transformation renders endothelial resistance to anti-VEGF treatment in glioblastoma. Liu T, Ma W, Xu H, Huang M, Zhang D, He Z, Zhang L, Brem S, O'Rourke DM, Gong Y, Mou Y, Zhang Z, Fan Y. Nat Commun. 2018 Aug 27;9(1):3439. doi: 10.1038/s41467-018-05982-z. PMID:30150753
• Targeting mitochondria in cancer: current concepts and immunotherapy approaches. Pustylnikov S, Costabile F, Beghi S, Facciabene A. Transl Res. 2018 Jul 31. pii: S1931-5244(18)30114-2. doi: 10.1016/j.trsl.2018.07.013.  Review. PMID:30144423
• A Clinical Trial of TumorGlow® to Identify Residual Disease during Pleurectomy and Decortication. Predina JD, Newton AD, Corbett C, Xia L, Shin M, Sulfyok LF, Okusanya OT, Cengel KA, Haas A, Litzky L, Kucharczuk JC, Singhal S. Ann Thorac Surg. 2018 Jul 17. pii: S0003-4975(18)30995-0. doi: 10.1016/j.athoracsur.2018.06.015. PMID:30028985
• Safety and Feasibility of Integrating Yttrium-90 Radioembolization With Capecitabine-Temozolomide for Grade 2 Liver-Dominant Metastatic Neuroendocrine Tumors. Soulen MC, van Houten D, Teitelbaum UR, Damjanov N, Cengel KA, Metz DC. Pancreas. 2018 Sep;47(8):980-984. doi: 10.1097/MPA.0000000000001115. PMID:30028446
• Radiosensitization by the PARP inhibitor olaparib in BRCA1-proficient and deficient high-grade serous ovarian carcinomas. Bi Y, Verginadis II, Dey S, Lin L, Guo L, Zheng Y, Koumenis C. Gynecol Oncol. 2018 Sep;150(3):534-544. doi: 10.1016/j.ygyno.2018.07.002. Epub 2018 Jul 17. PMID:30025822
• Pro-tumorigenic AMPK in glioblastoma. Leli NM, Koumenis C. Nat Cell Biol. 2018 Jul;20(7):736-737. doi: 10.1038/s41556-018-0129-9. PMID:29915356
• Protoporphyrin IX (PpIX)-Coated Superparamagnetic Iron Oxide Nanoparticle (SPION) Nanoclusters for Magnetic Resonance Imaging and Photodynamic Therapy. Yan L, Amirshaghaghi A, Huang D, Miller J, Stein JM, Busch TM, Cheng Z, Tsourkas A. Adv Funct Mater. 2018 Apr 17;28(16). pii: 1707030. doi: 10.1002/adfm.201707030. Epub 2018 Feb 15. PMID:29910700
• A quality assurance program for clinical PDT. Dimofte A, Finlay J, Ong YH, Zhu TC. Proc SPIE Int Soc Opt Eng. 2018 Mar;10476. pii: 104760L. doi: 10.1117/12.2288561. PMID:29861532
• Reactive Oxygen Species Explicit Dosimetry (ROSED) of a Type 1 Photosensitizer. Ong YH, Kim MM, Huang Z, Zhu TC. Proc SPIE Int Soc Opt Eng. 2018 Feb;10476. pii: 104760V. doi: 10.1117/12.2291385. PMID:29861531
• Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR. Walton ZE, Patel CH, Brooks RC, Yu Y, Ibrahim-Hashim A, Riddle M, Porcu A, Jiang T, Ecker BL, Tameire F, Koumenis C, Weeraratna AT, Welsh DK, Gillies R, Alwine JC, Zhang L, Powell JD, Dang CV. Cell. 2018 Jun 28;174(1):72-87.e32. doi: 10.1016/j.cell.2018.05.009. Epub 2018 May 31. PMID:29861175
• Monte Carlo modelling of fluorescence in semi-infinite turbid media. Ong YH, Finlay JC, Zhu TC. Proc SPIE Int Soc Opt Eng. 2018 Jan-Feb;10492. pii: 104920T. doi: 10.1117/12.2290137. Epub 2018 Feb 26. PMID:29853731
• Radiotherapy and CD40 Activation Separately Augment Immunity to Checkpoint Blockade in Cancer. Rech AJ, Dada H, Kotzin JJ, Henao-Mejia J, Minn AJ, Twyman-Saint Victor C, Vonderheide RH. Cancer Res. 2018 Aug 1;78(15):4282-4291. doi: 10.1158/0008-5472.CAN-17-3821. Epub 2018 May 29. PMID:29844122
• Determination of optical properties, drug concentration, and tissue oxygenation in human pleural tissue before and after Photofrin-mediated photodynamic therapy. Ong YH, Padawer-Curry J, Finlay JC, Kim MM, Dimofte A, Cengel K, Zhu TC. Proc SPIE Int Soc Opt Eng. 2018 Mar;10476. pii: 104760Y. doi: 10.1117/12.2290727. PMID:29805193
• A preclinical model to investigate the role of surgically-induced inflammation in tumor responses to intraoperative photodynamic therapy. Davis RW 4th, Papasavvas E, Klampatsa A, Putt M, Montaner LJ, Culligan MJ, McNulty S, Friedberg JS, Simone CB 2nd, Singhal S, Albelda SM, Cengel KA, Busch TM. Lasers Surg Med. 2018 Jul;50(5):440-450. doi: 10.1002/lsm.22934. Epub 2018 May 25. PMID:29799130
• Light Fluence Dosimetry in Lung-simulating Cavities. Zhu TC, Kim MM, Padawer J, Dimofte A, Potasek M, Beeson K, Parilov E. Proc SPIE Int Soc Opt Eng. 2018 Jan-Feb;10476. pii: 104760F. doi: 10.1117/12.2291355. Epub 2018 Mar 5. PMID:29780196
• A Two-Component Assay for Hypoxia Incorporating Long-Term Nitroreduction and Short-Term DNA-Damage Allows Differentiation of the Three Hypoxia Sub-types. Koch CJ. Radiat Res. 2018 Jul;190(1):72-87. doi: 10.1667/RR15029.1. Epub 2018 May 10. PMID:29746214
• Development of a stress response therapy targeting aggressive prostate cancer. Nguyen HG, Conn CS, Kye Y, Xue L, Forester CM, Cowan JE, Hsieh AC, Cunningham JT, Truillet C, Tameire F, Evans MJ, Evans CP, Yang JC, Hann B, Koumenis C, Walter P, Carroll PR, Ruggero D. Sci Transl Med. 2018 May 2;10(439). pii: eaar2036. doi: 10.1126/scitranslmed.aar2036. PMID:29720449
• Limitations in predicting the space radiation health risk for exploration astronauts. Chancellor JC, Blue RS, Cengel KA, Auñón-Chancellor SM, Rubins KH, Katzgraber HG, Kennedy AR. NPJ Microgravity. 2018 Apr 3;4:8. doi: 10.1038/s41526-018-0043-2. eCollection 2018. Review. PMID:29644336
• Fluorescence-guided surgery and intervention - An AAPM emerging technology blue paper. Pogue BW, Zhu TC, Ntziachristos V, Paulsen KD, Wilson BC, Pfefer J, Nordstrom RJ, Litorja M, Wabnitz H, Chen Y, Gioux S, Tromberg BJ, Yodh AG. Med Phys. 2018 Jun;45(6):2681-2688. doi: 10.1002/mp.12909. Epub 2018 Apr 25. PMID:29633297
• Combination Cancer Therapy with Immune Checkpoint Blockade: Mechanisms and Strategies. Patel SA, Minn AJ. Immunity. 2018 Mar 20;48(3):417-433. doi: 10.1016/j.immuni.2018.03.007. Review. PMID:29562193
• The dark side of tumor-associated endothelial cells. De Sanctis F, Ugel S, Facciponte J, Facciabene A. Semin Immunol. 2018 Feb;35:35-47. doi: 10.1016/j.smim.2018.02.002. Epub 2018 Feb 26. Review. PMID:29490888
• Image guidance doses delivered during radiotherapy: Quantification, management, and reduction: Report of the AAPM Therapy Physics Committee Task Group 180. Ding GX, Alaei P, Curran B, Flynn R, Gossman M, Mackie TR, Miften M, Morin R, Xu XG, Zhu TC. Med Phys. 2018 May;45(5):e84-e99. doi: 10.1002/mp.12824. Epub 2018 Mar 24. PMID:29468678
• Gut microbiota modulates adoptive cell therapy via CD8α dendritic cells and IL-12. Uribe-Herranz M, Bittinger K, Rafail S, Guedan S, Pierini S, Tanes C, Ganetsky A, Morgan MA, Gill S, Tanyi JL, Bushman FD, June CH, Facciabene A. JCI Insight. 2018 Feb 22;3(4). pii: 94952. doi: 10.1172/jci.insight.94952. PMID:29467322
• A Human Genome-Wide RNAi Screen Reveals Diverse Modulators that Mediate IRE1α-XBP1 Activation. Yang Z, Zhang J, Jiang D, Khatri P, Solow-Cordero DE, Toesca DAS, Koumenis C, Denko NC, Giaccia AJ, Le QT, Koong AC. Mol Cancer Res. 2018 May;16(5):745-753. doi: 10.1158/1541-7786.MCR-17-0307. Epub 2018 Feb 9. PMID:29440447
• Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2α. Wang Q, He Z, Huang M, Liu T, Wang Y, Xu H, Duan H, Ma P, Zhang L, Zamvil SS, Hidalgo J, Zhang Z, O'Rourke DM, Dahmane N, Brem S, Mou Y, Gong Y, Fan Y. Nat Commun. 2018 Feb 8;9(1):559. doi: 10.1038/s41467-018-03050-0. PMID:29422647
• Temporal DNA-PK activation drives genomic instability and therapy resistance in glioma stem cells. Wang Y, Xu H, Liu T, Huang M, Butter PP, Li C, Zhang L, Kao GD, Gong Y, Maity A, Koumenis C, Fan Y. JCI Insight. 2018 Feb 8;3(3). pii: 98096. doi: 10.1172/jci.insight.98096. PMID:29415883
• Tumour endothelial marker 1/endosialin-mediated targeting of human sarcoma. Guo Y, Hu J, Wang Y, Peng X, Min J, Wang J, Matthaiou E, Cheng Y, Sun K, Tong X, Fan Y, Zhang PJ, Kandalaft LE, Irving M, Coukos G, Li C. Eur J Cancer. 2018 Feb;90:111-121. doi: 10.1016/j.ejca.2017.10.035. Epub 2018 Jan 4. PMID:29304474
• A PERK-miR-211 axis suppresses circadian regulators and protein synthesis to promote cancer cell survival. Bu Y, Yoshida A, Chitnis N, Altman BJ, Tameire F, Oran A, Gennaro V, Armeson KE, McMahon SB, Wertheim GB, Dang CV, Ruggero D, Koumenis C, Fuchs SY, Diehl JA. Nat Cell Biol. 2018 Jan;20(1):104-115. doi: 10.1038/s41556-017-0006-y. Epub 2017 Dec 11. PMID:29230015
• Trial watch: DNA-based vaccines for oncological indications. Pierini S, Perales-Linares R, Uribe-Herranz M, Pol JG, Zitvogel L, Kroemer G, Facciabene A, Galluzzi L. Oncoimmunology. 2017 Nov 20;6(12):e1398878. doi: 10.1080/2162402X.2017.1398878. eCollection 2017. Review. PMID:29209575
• Maternal CD8+ T-cell depletion alleviates intrauterine inflammation-induced perinatal brain injury. Lei J, Xie L, Zhao H, Gard C, Clemens JL, McLane MW, Feller MC, Ozen M, Novak C, Alshehri W, Alhejaily N, Shabi Y, Rosenzweig JM, Facciabene A, Burd I. Am J Reprod Immunol. 2018 May;79(5):e12798. doi: 10.1111/aji.12798. Epub 2017 Dec 4. PMID:29205631
• Synthetic Secoisolariciresinol Diglucoside (LGM2605) Protects Human Lung in an Ex Vivo Model of Proton Radiation Damage. Velalopoulou A, Chatterjee S, Pietrofesa RA, Koziol-White C, Panettieri RA, Lin L, Tuttle S, Berman A, Koumenis C, Christofidou-Solomidou M. Int J Mol Sci. 2017 Nov 25;18(12). pii: E2525. doi: 10.3390/ijms18122525. PMID:29186841

• Shabason JE, Minn AJ. Radiation and Immune Checkpoint Blockade: From Bench to Clinic. Semin Radiat Oncol. 2017 Jul;27(3):289-98; PMID:28577836.
• Sattiraju A, Xiong X, Pandya DN, Wadas TJ, Xuan A, Sun Y, Jung Y, Solingapuram Sai KK, Dorsey JF, Li KC, Mintz A. Alpha particle enhanced Blood Brain/Tumor Barrier permeabilization in glioblastomas using integrin alpha-v beta-3 targeted liposomes. Mol Cancer Ther. 2017 Jun 15; PMID:28619756.
• Alley EW, Katz SI, Cengel KA, Simone CB, 2nd. Immunotherapy and radiation therapy for malignant pleural mesothelioma. Transl Lung Cancer Res. 2017 Apr;6(2):212-9; PMID:28529903; PMCID: PMC5420537.
• Das IJ, Andersen A, Chen ZJ, Dimofte A, Glatstein E, Hoisak J, Huang L, Langer MP, Lee C, Pacella M, Popple RA, Rice R, Smilowitz J, Sponseller P, Zhu T. State of dose prescription and compliance to international standard (ICRU-83) in intensity modulated radiation therapy among academic institutions. Pract Radiat Oncol. 2017 Mar - Apr;7(2):e145-e55; PMID:28274405.
• Nabet BY, Qiu Y, Shabason JE, Wu TJ, Yoon T, Kim BC, Benci JL, DeMichele AM, Tchou J, Marcotrigiano J, Minn AJ. Exosome RNA Unshielding Couples Stromal Activation to Pattern Recognition Receptor Signaling in Cancer. Cell. 2017;170(2):352-66 e13, PMID:28709002.
• Harding SM, Benci JL, Irianto J, Discher DE, Minn AJ, Greenberg RA. Mitotic progression following DNA damage enables pattern recognition within micronuclei. Nature. 2017; PMID: 28759889.
• Sivanand S, Rhoades S, Jiang Q, Lee JV, Benci J, Zhang J, Yuan S, Viney I, Zhao S, Carrer A, Bennett MJ, Minn AJ, Weljie AM, Greenberg RA, Wellen KE. Nuclear Acetyl-CoA Production by ACLY Promotes Homologous Recombination. Mol Cell. 2017;67(2):252-65 e6; PMID: 28689661.
• Baumann BC, Zeng C, Freedman GM, Verginadis, II, MacArthur KM, Lin LL, Vachani C, Koumenis C, Solberg TD, Metz JM. Avoiding antiperspirants during breast radiation therapy: Myth or sound advice? Radiother Oncol. 2017; PMID: 28733055.
• Mohapatra PP, Chiemezie CO, Kligman A, Kim MM, Busch TM, Zhu TC, Greer A. 31 P NMR Evidence for Peroxide Intermediates in Lipid Emulsion Photooxidations: Phosphine Substituent Effects in Trapping. Photochem Photobiol. 2017; PMID: 28722754.
• Lei J, Rosenzweig JM, Mishra MK, Alshehri W, Brancusi F, McLane M, Almalki A, Bahabry R, Arif H, Rozzah R, Alyousif G, Shabi Y, Alhehaily N, Zhong W, Facciabene A, Kannan S, Kannan RM, Burd I. Maternal dendrimer-based therapy for inflammation-induced preterm birth and perinatal brain injury. Sci Rep. 2017;7(1):6106. PMCID:28733619, PMC5522481.
• Yang L, Zhang Y, Shan W, Hu Z, Yuan J, Pi J, Wang Y, Fan L, Tang Z, Li C, Hu X, Tanyi JL, Fan Y, Huang Q, Montone K, Dang CV, Zhang L. Repression of BET activity sensitizes homologous recombination-proficient cancers to PARP inhibition. Sci Transl Med. 2017;9(400); PMID: 28747513.
• Chandra A, Wang L, Young T, Zhong L, Tseng WJ, Levine MA, Cengel K, Liu XS, Zhang Y, Pignolo RJ, Qin L. Proteasome inhibitor bortezomib is a novel therapeutic agent for focal radiation-induced osteoporosis. FASEB J. 2017; PMID: 28860152.
• Brady LK, Wang H, Radens CM, Bi Y, Radovich M, Maity A, Ivan C, Ivan M, Barash Y, Koumenis C. Transcriptome analysis of hypoxic cancer cells uncovers intron retention in EIF2B5 as a mechanism to inhibit translation. PLoS Biol. 2017;15(9):e2002623; PMID: 28961236; PMCID: PMC5636171.
• Christofidou-Solomidou M, Pietrofesa RA, Arguiri E, Koumenis C, Segal R. Radiation Mitigating Properties of Intranasally Administered Kl4 Surfactant in a Murine Model of Radiation-Induced Lung Damage. Radiat Res. 2017; PMID: 28877030; PMCID: PMC5704933
• Benci JL, Minn AJ, Vachani CC, Bach C, Arnold-Korzeniowski K, Hampshire MK, Metz JM, Hill-Kayser CE. Survivorship care planning in skin cancer: An unbiased statistical approach to identifying patterns of care-plan use. Cancer. 2017; PMID: 28885696. 
• Facciabene A, De Sanctis F, Pierini S, Reis ES, Balint K, Facciponte J, Rueter J, Kagabu M, Magotti P, Lanitis E, DeAngelis RA, Buckanovich RJ, Song WC, Lambris JD, Coukos G. Local endothelial complement activation reverses endothelial quiescence, enabling t-cell homing, and tumor control during t-cell immunotherapy. Oncoimmunology. 2017;6(9):e1326442. PMCID: 28932632, PMC5599081.
• Hoppe BS, Hill-Kayser CE, Tseng YD, Flampouri S, Elmongy HM, Cahlon O, Mendenhall NP, Maity A, McGee LA, Plastaras JP. Consolidative proton therapy after chemotherapy for patients with Hodgkin lymphoma. Ann Oncol. 2017;28(9):2179-84; PMID: 28911093. 
• Patel AM, Berger I, Wileyto EP, Khalid U, Torigian DA, Nachiappan AC, Barbosa EM, Jr., Gefter WB, Galperin-Aizenberg M, Gupta NK, Simone CB, 2nd, Haas AR, Alley EW, Singhal S, Cengel KA, Katz SI. The value of delayed phase enhanced imaging in malignant pleural mesothelioma. J Thorac Dis. 2017;9(8):2344-9. PMCID:28932538,  PMC5594138.
• Verginadis, II, Kanade R, Bell B, Koduri S, Ben-Josef E, Koumenis C. A Novel Mouse Model to Study Image-Guided, Radiation-Induced Intestinal Injury and Preclinical Screening of Radioprotectors. Cancer Res. 2017;77(4):908-17.
• Kim MM, Ghogare AA, Greer A, Zhu TC. On the in vivo photochemical rate parameters for PDT reactive oxygen species modeling. Phys Med Biol. 2017;62(5):R1-48.
• Qiu H, Kim MM, Penjweini R, Finlay JC, Busch TM, Wang T, Guo W, Cengel KA, Simone CB, 2nd, Glatstein E, Zhu TC. A Comparison of Dose Metrics to Predict Local Tumor Control for Photofrin-mediated Photodynamic Therapy. Photochem Photobiol. 2017.
• Friedberg JS, Simone CB, 2nd, Culligan MJ, Barsky AR, Doucette A, McNulty S, Hahn SM, Alley E, Sterman DH, Glatstein E, Cengel KA. Extended Pleurectomy-Decortication-Based Treatment for Advanced Stage Epithelial Mesothelioma Yielding a Median Survival of Nearly Three Years. Ann Thorac Surg. 2017;103(3):912-9.
• Katlinski KV, Gui J, Katlinskaya YV, Ortiz A, Chakraborty R, Bhattacharya S, Carbone CJ, Beiting DP, Girondo MA, Peck AR, Pure E, Chatterji P, Rustgi AK, Diehl JA, Koumenis C, Rui H, Fuchs SY. Inactivation of Interferon Receptor Promotes the Establishment of Immune Privileged Tumor Microenvironment. Cancer Cell. 2017;31(2):194-207. PMCID: PMC5313042.
• Chandra A, Lin T, Young T, Tong W, Ma X, Tseng WJ, Kramer I, Kneissel M, Levine MA, Zhang Y, Cengel K, Liu XS, Qin L. Suppression of Sclerostin Alleviates Radiation-Induced Bone Loss by Protecting Bone-Forming Cells and Their Progenitors Through Distinct Mechanisms. J Bone Miner Res. 2017;32(2):360-72.
• Gemmell NR, McCarthy A, Kim MM, Veilleux I, Zhu TC, Buller GS, Wilson BC, Hadfield RH. A compact fiber-optic probe-based singlet oxygen luminescence detection system. J Biophotonics. 2017;10(2):320-6. PMCID: PMC5266677.
• Benci JL, Xu B, Qiu Y, Wu TJ, Dada H, Twyman-Saint Victor C, Cucolo L, Lee DS, Pauken KE, Huang AC, Gangadhar TC, Amaravadi RK, Schuchter LM, Feldman MD, Ishwaran H, Vonderheide RH, Maity A, Wherry EJ, Minn AJ. Tumor Interferon Signaling Regulates a Multigenic Resistance Program to Immune Checkpoint Blockade. Cell. 2016;167(6):1540-54 e12.
• Kim MM, Penjweini R, Gemmell NR, Veilleux I, McCarthy A, Buller GS, Hadfield RH, Wilson BC, Zhu TC.A Comparison of Singlet Oxygen Explicit Dosimetry (SOED) and Singlet Oxygen Luminescence Dosimetry (SOLD) for Photofrin-Mediated Photodynamic Therapy. Cancers (Basel). 2016;8(12). PMCID: PMC5187507.
• Ong YH, Zhu TC.Analytic function for predicting light fluence rate of circular fields on a semi-infinite turbid medium. Opt Express. 2016;24(23):26261-81. PMCID: PMC5234503.
• Liu TR, Xiao ZW, Xu HN, Long Z, Wei FQ, Zhuang SM, Sun XM, Xie LE, Mu JS, Yang AK, Zhang GP, Fan Y. Treatment and Prognosis of Anaplastic Thyroid Carcinoma: A Clinical Study of 50 Cases. PLoS One. 2016;11(10):e0164840.
• Kim MM, Penjweini R, Liang X, Zhu TC. Explicit macroscopic singlet oxygen modeling for benzoporphyrin derivative monoacid ring A (BPD)-mediated photodynamic therapy. J Photochem Photobiol B. 2016;164:314-22. PMCID: PMC5079817.
• Penjweini R, Kim MM, Liu B, Zhu TC. Evaluation of the 2-(1-Hexyloxyethyl)-2-devinyl pyropheophorbide (HPPH) mediated photodynamic therapy by macroscopic singlet oxygen modeling. J Biophotonics. 2016.
• Qiu H, Kim MM, Penjweini R, Zhu TC. Macroscopic singlet oxygen modeling for dosimetry of Photofrin-mediated photodynamic therapy: an in-vivo study. J Biomed Opt. 2016;21(8):88002.
• Kennedy AR, Maity A, Sanzari JK. A Review of Radiation-Induced Coagulopathy and New Findings to Support Potential Prevention Strategies and Treatments. Radiat Res. 2016.
• Brady LK, Popov V, Koumenis C. In Vivo Interrogation of the Hypoxic Transcriptome of Solid Tumors: Optimizing Hypoxic Probe Labeling with Laser Capture Microdissection for Isolation of High-Quality RNA for Deep Sequencing Analysis. Adv Exp Med Biol. 2016;899:41-58.
• Sun L, Joh DY, Al-Zaki A, Stangl M, Murty S, Davis JJ, Baumann BC, Alonso-Basanta M, Kaol GD, Tsourkas A, Dorsey JF. Theranostic Application of Mixed Gold and Superparamagnetic Iron Oxide Nanoparticle Micelles in Glioblastoma Multiforme. J Biomed Nanotechnol. 2016;12(2):347-56. PMCID: PMC4942305.
• Cengel KA, Simone CB, 2nd, Glatstein E. PDT: What's Past Is Prologue. Cancer Res. 2016;76(9):2497-9.
• Gabriel PE, Woodhouse KD, Lin A, Finlay JC, Young RB, Volz E, Hahn SM, Metz JM, Maity A.An automated electronic system for managing radiation treatment plan peer review reduces missed reviews at a large, high-volume academic center. Pract Radiat Oncol. 2016.
• Minn AJ, Wherry EJ. Combination Cancer Therapies with Immune Checkpoint Blockade: Convergence on Interferon Signaling. Cell. 2016;165(2):272-5.
• Huang M, Liu T, Ma P, Mitteer RA, Jr., Zhang Z, Kim HJ, Yeo E, Zhang D, Cai P, Li C, Zhang L, Zhao B, Roccograndi L, O'Rourke DM, Dahmane N, Gong Y, Koumenis C, Fan Y. c-Met-mediated endothelial plasticity drives aberrant vascularization and chemoresistance in glioblastoma. J Clin Invest. 2016.
• Woodhouse KD, Volz E, Maity A, Gabriel PE, Solberg TD, Bergendahl HW, Hahn SM. Journey Toward High Reliability: A Comprehensive Safety Program to Improve Quality of Care and Safety Culture in a Large, Multisite Radiation Oncology Department. J Oncol Pract. 2016;12(5):e603-12.
• Daurio NA, Tuttle SW, Worth AJ, Song EY, Davis JM, Snyder NW, Blair IA, Koumenis C. AMPK Activation and Metabolic Reprogramming by Tamoxifen through Estrogen Receptor-Independent Mechanisms Suggests New Uses for This Therapeutic Modality in Cancer Treatment. Cancer Res. 2016.
• Ahn PH, Quon H, O'Malley BW, Weinstein G, Chalian A, Malloy K, Atkins JH, Sollecito T, Greenberg M, McNulty S, Lin A, Zhu TC, Finlay JC, Cengel K, Livolsi V, Feldman M, Mick R, Busch TM. Toxicities and early outcomes in a phase 1 trial of photodynamic therapy for premalignant and early stage head and neck tumors. 2016;55:37-42. PMCID: PMC4943020.
• Grossman CE, Carter SL, Czupryna J, Wang L, Putt ME, Busch TM. Fluence Rate Differences in Photodynamic Therapy Efficacy and Activation of Epidermal Growth Factor Receptor after Treatment of the Tumor-Involved Murine Thoracic Cavity. Int J Mol Sci. 2016;17(1). PMCID: PMC4730343.
• Evans SM, Putt M, Yang XY, Lustig RA, Martinez-Lage M, Williams D, Desai A, Wolf R, Brem S, Koch CJ. Initial evidence that blood-borne microvesicles are biomarkers for recurrence and survival in newly diagnosed glioblastoma patients. J Neurooncol. 2016;127(2):391-400. PMCID: PMC4783260.
• Xu MJ, Dorsey JF, Amaravadi R, Karakousis G, Simone CB, 2nd, Xu X, Xu W, Carpenter EL, Schuchter L, Kao GD. Circulating Tumor Cells, DNA, and mRNA: Potential for Clinical Utility in Patients With Melanoma. Oncologist. 2016;21(1):84-94. PMCID: PMC4709205.
• Milgrom SA, Jauhari S, Plastaras JP, Nieto Y, Dabaja BS, Pinnix CC, Smith GL, Allen PK, Lukens JN, Maity A, Oki Y, Fanale MA, Nasta SD. A multi-institutional analysis of peritransplantation radiotherapy in patients with relapsed/refractory Hodgkin lymphoma undergoing autologous stem cell transplantation. Cancer. 2016.
• Zhang B, Wong JW, Iordachita, II, Reyes J, Nugent K, Tran PT, Tuttle SW, Koumenis C, Wang KK. Evaluation of On- and Off-Line Bioluminescence Tomography System for Focal Irradiation Guidance. Radiat Res. 2016.
• Wang P, Cammin J, Bisello F, Solberg TD, McDonough JE, Zhu TC, Menichelli D, Teo BK. roton computed tomography using a 1D silicon diode array. Med Phys. 2016;43(10):5758.
• Jiang Y, Qiu Y, Minn AJ, Zhang NR. Assessing intratumor heterogeneity and tracking longitudinal and spatial clonal evolutionary history by next-generation sequencing. Proc Natl Acad Sci U S A. 2016;113(37):E5528-37. PMCID: PMC5027458.
• Pietrofesa RA, Velalopoulou A, Lehman SL, Arguiri E, Solomides P, Koch CJ, Mishra OP, Koumenis C, Goodwin TJ, Christofidou-Solomidou M. Novel Double-Hit Model of Radiation and Hyperoxia-Induced Oxidative Cell Damage Relevant to Space Travel. Int J Mol Sci. 2016;17(6). PMCID: PMC4926486.
• Shah S, Carriveau WJ, Li J, Campbell SL, Kopinski PK, Lim HW, Daurio N, Trefely S, Won KJ, Wallace DC, Koumenis C, Mancuso A, Wellen KE. Targeting ACLY sensitizes castration-resistant prostate cancer cells to AR antagonism by impinging on an ACLY-AMPK-AR feedback mechanism. Oncotarget. 2016.
• Xu Z, Bu Y, Chitnis N, Koumenis C, Fuchs SY, Diehl JA. miR-216b regulation of c-Jun mediates GADD153/CHOP-dependent apoptosis. Nat Commun. 2016;7:11422. PMCID: PMC4869177.
• Zhang Y, He Q, Hu Z, Feng Y, Fan L, Tang Z, Yuan J, Shan W, Li C, Hu X, Tanyi JL, Fan Y, Huang Q, Montone K, Dang CV, Zhang L. Long noncoding RNA LINP1 regulates repair of DNA double-strand breaks in triple-negative breast cancer. Nat Struct Mol Biol. 2016;23(6):522-30. PMCID: PMC4927085.
• Katlinskaya YV, Katlinski KV, Yu Q, Ortiz A, Beiting DP, Brice A, Davar D, Sanders C, Kirkwood JM, Rui H, Xu X, Koumenis C, Diehl JA, Fuchs SY. Suppression of Type I Interferon Signaling Overcomes Oncogene-Induced Senescence and Mediates Melanoma Development and Progression. Cell Rep. 2016;15(1):171-80. PMCID: PMC4826807.
• Wander SA, Zhao D, Besser AH, Hong F, Wei J, Ince TA, Milikowski C, Bishopric NH, Minn AJ, Creighton CJ, Slingerland JM. Erratum to: PI3K/mTOR inhibition can impair tumor invasion and metastasis in vivo despite a lack of antiproliferative action in vitro: implications for targeted therapy. Breast Cancer Res Treat. 2016;156(2):405-6.
• Sterman DH, Alley E, Stevenson JP, Friedberg J, Metzger S, Recio A, Moon EK, Haas AR, Vachani A, Katz SI, Sun J, Heitjan D, Hwang WT, Litzky L, Yearley JH, Tan KS, Papasavvas E, Kennedy P, Montaner L, Cengel KA, Simone CB, Culligan M, Langer C, Albelda SM. Pilot and Feasibility Trial Evaluating Immuno-Gene Therapy of Malignant Mesothelioma Using Intrapleural Delivery of Adenovirus-IFNα Combined with Chemotherapy. Clin Cancer Res. 2016.
• Rimner A, Simone CB, 2nd, Zauderer MG, Cengel KA, Rusch VW. Hemithoracic radiotherapy for mesothelioma: lack of benefit or lack of statistical power? Lancet Oncol. 2016;17(2):e43-4.
• Woodhouse KD, Volz E, Bellerive M, Bergendahl HW, Gabriel PE, Maity A, Hahn SM, Vapiwala N. The implementation and assessment of a quality and safety culture education program in a large radiation oncology department. Pract Radiat Oncol. 2016;6(4):e127-34.
• Klionsky DJ et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016;12(1):1-222.
• Zhang Y, Feng Y, Hu Z, Hu X, Yuan CX, Fan Y, Zhang L. Characterization of Long Noncoding RNA-Associated Proteins by RNA-Immunoprecipitation. Methods Mol Biol. 2016;1402:19-26. PMCID: PMC4773202.
• Ghogare AA, Miller JM, Mondal B, Lyons AM, Cengel KA, Busch TM, Greer A. Fluorinated Photodynamic Therapy Device Tips and their Resistance to Fouling for In Vivo Sensitizer Release. Photochem Photobiol. 2016;92(1):166-72. PMCID: PMC4839978.