John P. Plastaras, M.D., Ph.D.
Areas of Interest
Clinical Interests: I specialize in radiation for patients with gastrointestinal malignancies (esophagus, stomach, biliary tree, pancreas, colon, rectum, anus). Lymphoma, Myeloma, Leukemia.
I am especially interested in translational research. In GI cancer, I am interested in combining novel targeted agents with chemoradiation to improve cancer outcomes. I am also interested in using imaging techniques, such as PET, to better understand how much radiation dose tumors receive during radioimmunotherapy.
Education
2003 - 2007
Residency, Radiation Oncology
B. Leonard Holman Research Pathway Resident
Hospital of the University of Pennsylvania, Philadelphia, PA
2002 - 2003
Transitional Internship
Memorial Sloan-Kettering Cancer Center, New York, NY
1994 - 2002
Doctor of Medicine
Vanderbilt University, Nashville, TN
1994 - 2000
Doctor of Philosophy, Biochemistry
Vanderbilt University, Nashville, TN
Dissertation: DNA Adduct Formation by Malondialdehyde and Structurally Related Compounds
Committee Chair: Lawrence J. Marnett, PhD
1990 - 1994
Master of Science, Chemistry
Emory University, Atlanta, GA
Thesis: Molecular Modeling of Platinum Anti-Cancer Drugs Bound to N7 of Guanine
Research Advisor: Luigi G. Marzilli, PhD
1990 - 1994
Bachelor of Science with Highest Honors, Chemistry
Bachelor of Arts, Biology
Emory University, Atlanta
Faculty Appointment
July 2007
Clinical Instructor, Department of Radiation Oncology
University of Pennsylvania, Philadelphia
Peer-Reviewed Publications
Harris E.E.R., Hwang W.T., Urtishak S.L., Plastaras J.P., Kinosian B., Solin LJ. (2007) The impact of comorbidities on outcomes for elderly women treated with breast-conservation treatment for early-stage breast cancer. Int J Radiat Oncol Biol Phys Oct 30 Epub ahead of print.
Plastaras, J.P., Liu, Y., Kim, S-H., Dicker, D.T., McDonough, J., Dorsey, J.F., Flaherty, K., Smith, C., El-Deiry, W.S. (2007) Cell cycle and schedule dependent anti-tumor effects of sorafenib combined with radiation.” Cancer Research. 67:9443-9454.
Harris, E.E.R., Hwang, W.-T., Urtishak, S.L., Plastaras, J.P., Kinosian, B., Solin, L.J. “The impact of co-morbidities on ten-year outcomes for elderly women treated with breast-conserving therapy for early stage breast cancer.” Under review at Cancer.
Ricci, M.S., Kim, S-H., Ogi, K., Plastaras, J.P., Ling, J., Wang, W., Jin, Z., Liu, Y.Y., Dicker, D.T., Chiao, P.J., Flaherty, K., Smith, C., El-Deiry, W.S. (2007) “Repression of TRAIL-induced Mcl-1 and CIAP2 expression by c-Myc or BAY 43-9006 (Sorafenib) sensitizes resistant human cancer cells to TRAIL-induced death.” Cancer Cell 12:66-80.
Mayes, P.A., Campbell, L., Ricci, M.S., Plastaras, J.P., Dicker, D.T., El-Deiry, W.S. (2005) “Modulation of TRAIL-induced tumor cell apoptosis in a hypoxic environment.” Cancer Biol Ther 4:1068-74.
Plastaras, J.P., Harris, E.E.R., and Solin, L.J. (2005) “Paget’s disease of the nipple as local recurrence following breast conservation treatment for early stage breast cancer.” Clinical Breast Cancer 6:349-53.
Kadiiska, M.B., Gladen, B.C., Baird, D.D., Graham, L.B., Parker, C.E., Ames, B.N., Basu, S., Fitzgerald, G.A., Lawson, J.A., Marnett, L.J., Morrow, J.D., Murray, D.M., Plastaras, J.P., Roberts, L.J. 2nd, Rokach, J., Shigenaga, M.K., Sun, J., Walter, P.B., Tomer, K.B., Barrett, J.C., Mason, R.P. (2005) “Biomarkers of oxidative stress study III. Effects of the nonsteroidal anti-inflammatory agents indomethacin and meclofenamic acid on measurements of oxidative products of lipids in CCl(4) poisoning.” Free Radic Biol Med. 38:711-8.
Kadiiska, M.B., Gladen, B.C., Baird, D.D., Germolec, D., Graham, L.B., Parker, C.E., Nyska, A., Wachsman, J.T., Ames, B.N., Basu, S., Brot, N., Fitzgerald, G.A., Floyd, R.A., George, M., Heinecke, J.W., Hatch, G.E., Hensley, K., Lawson, J.A., Marnett, L.J., Morrow, J.D., Murray, D.M., Plastaras, J.P., Roberts, L.J. 2nd, Rokach, J., Shigenaga, M.K., Sohal, R.S., Sun, J., Tice, R.R., Van Thiel, D.H., Wellner, D., Walter, P.B., Tomer, K.B., Mason, R.P., Barrett, J.C. (2005) “Biomarkers of Oxidative Stress Study II: Are oxidation products of lipids, proteins, and DNA markers of CCl(4) poisoning?” Free Radic Biol Med. 38:698-710.
Plastaras, J.P., Dedon, P.C., and Marnett, L.J. (2002) “Effects of DNA structure on oxopropenylation by the endogenous mutagens, malondialdehyde and base propenal.” Biochemistry 41:5033-42.
Otteneder, M., Plastaras, J.P., and Marnett, L.J. (2002) “Reaction of malondialdehyde-DNA adducts with hydrazines – Development of a facile assay for quantification of malondialdehyde equivalents in DNA.” Chem. Res. Toxicol. 15:312-318.
Sharma, R.A., Gescher, A., Plastaras, J.P., Leuratti, C., Singh, R., Gallacher-Horley, B., Offord, E., Marnett, L.J., Steward, W.P., and Plummer, S.M. (2001) “Cyclooxygenase-2, malondialdehyde and pyrimidopurinone adducts of deoxyguanosine in human colon cells.” Carcinogenesis, 22:1557-1560.
Plastaras, J.P., Riggins, J.N., Otteneder, M., and Marnett, L.J. (2000) “Reactivity and mutagenicity of endogenous DNA oxopropenylating agents: base propenals, malondialdehyde, and Ne-oxopropenyllysine.” Chem. Res. Toxicol. 13:1235-1242.
Plastaras, J.P., Guengerich, F.P., Nebert, D.W., and Marnett, L.J. (2000) “Xenobiotic metabolizing cytochromes P450 convert prostaglandin endoperoxide to hydroxyheptadecatrienoic acid and the mutagen, malondialdehyde.” J.Biol.Chem. 275:11784-11790.
Dedon, P.C., Plastaras, J.P., Rouzer, C.A., and Marnett, L.J. (1998) “Indirect mutagenesis by oxidative DNA damage: Formation of the pyrimidopurinone adduct of dexoyguanosine by base propenal.” Proc. Natl. Acad. Sci. USA 95:11113-11116.
Leuratti, C., Singh, R., Lagneau, C., Farmer, P.B., Plastaras, J.P., Marnett, L.J., and Shuker, D.E.G. (1998) “Determination of malondialdehyde-induced DNA damage in human tissues using an immunoslot blot assay.” Carcinogenesis 19:1919-1924.
Kadlubar, F.F., Anderson, K.E., Lang, N.P., Thompson, P.A., MacLeod, S.L., Chou, M.W., Mikhailova, M., Plastaras, J.P., Marnett, L.J., Häussermann, S., Nair, J., Velic, I., and Bartsch, H. (1998) “Comparison of DNA adduct levels associated with oxidative stress in human pancreas.” Mutat. Res. 405:125-133.
Yao, S., Plastaras, J.P., and Marzilli, L.G. (1994) “A molecular mechanics AMBER-type force field for modeling platinum complexes of guanine derivatives.” Inorg. Chem. 33:6061-6077.
Reviews, Commentary and Book Chapters
Plastaras, J.P., Green, D.M., D’Angio, G.J. “Chapter 67. Second Malignant Neoplasms” In Abeloff, M., Armitage, J., Niederhuber, J., Kastan, M., McKenna, W.G., editors. Clinical Oncology, 4th Edition. Churchill Linvingstone. In press.
Plastaras, J.P. and Cengel, K.A. (2006) “Combination therapy with gemcitabine and 5-fluorouracil: unblocking the pathways to survivin?” Cancer Biol Ther 5(11)
Marnett, L.J. and Plastaras, J.P. (2001) “Endogenous DNA damage and mutation.” Trends Genet. 17:214-221.
Leuratti, C., Singh, R., Deag, E.J., Griech, E., Hughes, R., Bingham, S.A., Plastaras, J.P., Marnett, L.J., and Shuker, D.E.G. (1999) “A sensitive immunoslot-blot assay for the detection of malondialdehyde-deoxyguanosine in human DNA.” In Singer, B. and Bartsch, H., editors. IARC Scientific Publications: DNA Cyclic Adducts, International Agency for Research on Cancer, Lyon.
Plastaras, J.P. and Marnett, L.J. (1999) “Measurement of a malondialdehyde-DNA adduct.” In Maines, M. and Reed, D.J., editors. Current Protocols in Toxicology, John Wiley & Sons, Inc., New York.
Honors and Awards
2006
Roentgen Resident/Fellow Research Award
Radiological Society of North America
2004
Holman Pathway Research Resident Seed Grant
Radiological Society of North America
2002
John G. Coniglio Prize in Biochemistry
Vanderbilt University School of Medicine
1996
Alpha Omega Alpha Medical Honor Society
Vanderbilt University School of Medicine
Professional Activities
2007-Present
Member, Evaluation Subcommittee of the Emerging Technology Steering Committee
American Society of Therapeutic Radiation Oncology
2007-Present
Member, Institutional Review Board
University of Pennsylvania
2005-Present
Staff Writer for OncoLink
Abramson Cancer Center, University of Pennsylvania
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