Perelman School of Medicine at the University of Pennsylvania

Koch Lab

Cameron J. Koch , Ph.D.
Professor
Cameron J. Koch
Radiation Oncology, University of Pennsylvania,
185 John Morgan Bldg.,
3620 Hamilton Walk,
Philadelphia, PA 19104-6702
Phone: 215-898-0073
Fax: 215-898-0090
KOCHC@MAIL.MED.UPENN.EDU
 
Lab Members:
 
W. Tim Jenkins, M.S.
Position in Lab: Laboratory Manager
Education: Rutgers University, B.A.
University of Texas, M.S.
Email: wtj@mail.med.upenn.edu
 

Areas of Interest and Expertise

Measurement of radioresistant hypoxic tumor cells in vivo using:
  • immunohistochemistry and/or flow cytometry
  • non-invasive imaging
  • Quantification of tissue pO2
  • Control and measurement of oxygen concentration and thiols
  • Quantitative Fluorescence Microscopy
  • Oxidative damage (primarily sulfydryl to disulfide) of DNA repair systems
  • Effects of oxygen and oxygen radicals in biological or biochemical systems
  • Development of fluorine-based PET imaging methods
  • Automated chemical synthesis
  • Mechanisms of action of radiation sensitizing and radiation protecting agents (survival or DNA damage)
  • Models for competitive reactions of radiation modifying agents
  • Metabolism of thiols and nitroheterocyclics (including cytotoxicity)
  • Measurement of intracellular drug concentrations


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