Keith A. Cengel, M.D., Ph.D.
Assistant Professor of Radiation Oncology

University of Pennsylvania School of Medicine
Department of Radiation Oncology
John Morgan 180H
Philadelphia , PA 19104
Phone: 215-898-1035
Fax: 215-898-0090

Phoenixville Hospital
824 Main Street, Suite 101
Phoenixville, PA 19460
Phone: 610-983-1779
Fax: 610-983-1799

Education

• 1987-91 B.S.  University of Illinois at Urbana-Champaign
• 1991-93 M.S.  University of Illinois at Urbana-Champaign
• 1993-98 Ph.D. University of Illinois at Urbana-Champaign
• 1991-2001 M.D. University of Illinois College of Medicine

Areas of Interest

Dr. Cengel's areas of interest include treatment of patients with intra-peritoneal spread of gastrointestinal and ovarian cancers with intraoperative photodynamic therapy as well as treating patients with sarcoma with radiation therapy. He also consults on and treats patients in the Department of Radiation Oncology at Phoenixville Hospital and provides cross coverage for the other Clinics of the Department.

Dr. Cengel maintains a translational and basic research laboratory that studies gastrointestinal and ovarian tumor cell biology. Specific interests within basic/translational research of the Cengel Laboratory include a focus on the ability of growth factor signaling to modulate the sensitivity of cancer cells to radiation therapy and photodynamic therapy.

For the Cengel Laboratory website, please go to http://www.xrt.upenn.edu/Cengel_Lab.shtml

Recent Publications

Cengel, KA and Plastaras, JP (2006) Combination Therapy with Gemcitabine and 5-Fluorouracil: Unblocking the Pathways to Survivin? Cancer Biol Ther, In Press

Machtay, M, Scherpereel, A, Santiago, J, McDonough, J, Kinniry, P, Arguiri, E. Sun, J, Cengel, KA, Solomides, CC, Christofidou-Solomidou, M.  (2006)  Systemic Polyethelene Glycol-Modified (Pegylated)- Superoxide Dismutase and Catalase Mixture Attenuates Radiation Pulmonary Fibrosis in the C57BL/6 Mouse.  Radiother Oncol, In Press

Cengel, KA, Deutsch, E, Stephens, TC, Voong, KR, Kao, GD, Bernhard, EB.  (2006)  Radiosensitizing effects of the prenyltransferase inhibitor AZD3409 against -RAS mutated cell lines.  Cancer Biol Ther, 5: e1-e5.

Harris, EE, Hwang, WT, Feldman, M, Lee, E, Cengel, KA, Rembert, J. DeMichele, A, Kao, G, Solin, L. (2006) The Impact of Her2/neu Status on Local Recurrence in Women With Stage I-II Breast Cancer Treated With Breast Conservation Therapy. Breast J, J, 12: 431-436.

Cengel, KA, Glatstein, E and Hahn, SM (2005)  C225 and PDT combination therapy for ovarian cancer:  The play’s the thing. J Natl Cancer Inst 97: 488-489.

Cengel, KA, McKenna, WG (2005) Molecular targets for altering radiosensitivity: Lessons from Ras as a preclincal and clinical model. Crit Rev Hematol Oncol 55: 103-116.

Kaliski, A, Maggiorella, L, Cengel, KA, Mathe, D, Rouffiac, V, Opolon, P, Perroneau, P, Lassau, N, Bourhis , J, Deutsch, E (2005) Angiogenesis and tumour growth inhibition by an MMP-inhibitor targeting radiation-induced invasion. Submitted to Mol Cancer Ther., 4: 1717-1728.

Brunner, TB, Cengel, KA, Hahn, SM, Wu, J, Fraker, D, McKenna, WG and Bernhard, EJ. (2005) Prenyltransferase Inhibition of Pancreatic Cell Radiation Survival: The Role of K-Ras. Cancer Res, 65:8433-8441. 

Cengel, KA. (2004) Targeting Sonic Hedgehog: A New Way to Mow Down Pancreatic Cancer? Cancer Biol Ther 3: 165-166.

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