Gary Kao, M.D., Ph.D.
Associate Professor of Radiation Oncology

University of Pennsylvania School of Medicine
Department of Radiation Oncology
John Morgan 180H
Philadelphia , PA 19104
Phone: 215-573-2285
Fax: 215-573-8769

Philadelphia VA Medical Center
University and Woodland Avenues
Philadelphia , PA 19104
Phone: 215-823-5855
Fax: 215-823-4117

Education

• 1980-84 B.A.   Johns Hopkins University (Philosophy)
• 1984-88 M.D.  Johns Hopkins School of Medicine
• 1993-98 Ph.D. University of Pennsylvania

Board Certifications

• American Board of Radiology, Radiation Oncology, 1994

Areas of Interest

Dr. Kao is Chief of the Prostate Brachytherapy Services of both the Hospital of the University of Pennsylanvia as well as the Philadelphia Veterans Affairs Medical Center (PVAMC). He consults on and treats patients with prostate cancer at the Department of Radiation Oncology at both institutions. Dr. Kao also provides cross coverage for the other Clinics of the Department.

Dr. Kao also maintains a translational and basic research laboratory that studies prostate, breast, and brain tumor cell biology. Specific interests within basic/translational research of the Kao also includes a focus on mechanisms of cancer cell death, cell cycle checkpoints, and DNA damage. For the Kao Laboratory website, please go to http://www.xrt.upenn.edu/GaryKao.shtml

Recent Publications

Blank K, Cascardi M and Kao G. The utility of serial CBC in patients with prostate cancer. Int J Rad Oncol Biol Phys. 44(2): 317-21, 1999.

Kao G and Devine P. Use of complementary health practices by prostate carcinoma patients undergoing radiation therapy. Cancer 88(3): 615-9, 2000.

Kao G, McKenna WG and Yen TJ.  Detection of repair activity during the DNA Damage-induced G2 Delay.  Oncogene, (27): 3486-96, 2001.

Kao GD, McKenna MG, Guenther MG, Muschel RJ, Lazar MA, Yen TJ.  Histone deacetylase 4 interacts with 53BP1 to mediate the DNA damage response.  J Cell Biol. Mar 31;160(7):1017-27, 2003.

Daniel R, Kao G, Taganov K, Greger JG, Favorova O, Merkel G, Yen TJ, Katz RA, Skalka AM.  Evidence that the retroviral DNA integration process triggers an ATR-dependent DNA damage response.  Proc Natl Acad Sci U S A. Apr 15;100(8):4778-83, 2003.

Lee EA, Keutmann MK, Dowling M, Harris E, Chan E, Kao GD.  Inactivation of the mitotic checkpoint targets human cancer cells to killing by microtubule-disrupting drugs.  Molec Cancer Ther, 3(6):661-9, 2004.

Liu F, Dowling M, Yang XJ, Kao GD. Caspase-mediated specific cleavage of human histone deacetylase 4 (HDAC4).  J Biol Chem, 279(33):34537-46, 2004.

Dowling M, Voong KR, Kim MJ, Keutmann M, Harris E, Kao GD.  Mitotic spindle checkpoint inactivation by Trichostatin A defines a mechanism for increasing cancer cell killing by microtubule-disrupting agents .  Cancer Biol Ther, 4:2. e86-e95, EPUB ahead of print, 2005.

Kim M, Murphy K, Liu F, Parker S, Dowling ML, Baff W, Kao GD. Caspase-mediated specific cleavage of BubR1 is a determinant of the mitotic spindle checkpoint. Molecular and Cellular Biology, 25(21):9232-48, 2005.

Liu F, Pore N, Kim M, Voong KR, Dowling M, Maity A, Kao GD. Regulation of histone deacetylase 4 expression by the SP family of transcription factors. Molecular Biology of the Cell. Feb; 17(2):585-97, 2006.

Kim IA, Shin JH, Kim IH, Kim JH, Kim JS, Wu HG, Chie EK, Ha SW, Park CI, Kao GD. Histone deacetylase inhibitor-mediated radiosensitization of human cancer cells: class differences and the potential influence of p53. Clin Cancer Res. Feb 1; 12(3 Pt 1): 940-9, 2006.

Pore N, Jiang Z, Gupta A, Cerniglia G, Kao GD, Maity A. EGFR tyrosine kinase inhibitors decrease VEGF expression by both hypoxia-inducible factor (HIF)-1-independent and HIF-1-dependent mechanisms. Cancer Research. Mar 15; 66(6): 3197-204, 2006.

Farkash EA, Kao GD, Horman SR, Prak ET. Gamma radiation increases endonuclease-dependent L1 retrotransposition in a cultured cell assay. Nucleic Acids Res. Feb 28; 34(4):1196-204, 2006.

Geiger G, Parker S, Beothy A, Tucker J, Mullins MC, Kao GD. Zebrafish as a ‘‘Biosensor’’? Effects of ionizing radiation and amifostine on embryonic viability and development. Cancer Research, 66: (16), August 15, 2006.

Li Y, Kao GD, Garcia BA, Shabanowitz J, Hunt DF, Qin J, Phelan C, Lazar MA. A novel histone deacetylase pathway regulates mitosis by modulating Aurora B kinase activity. Genes and Development, 20 (18): 2566-2579, 2006.

Yu J, Palmer C, Alenghat T, Li Y, Kao GD, Lazar MA. The Corepressor SMRT facilitates cellular recovery from DNA double-strand breaks. Cancer Research, in press, 2006.

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