Gary Kao, M.D., Ph.D.
Associate Professor of Radiation Oncology

University of Pennsylvania School of Medicine
Department of Radiation Oncology
John Morgan 180H
Philadelphia , PA 19104

Education

• 1980-84 B.A.   Johns Hopkins University (Philosophy)
• 1984-88 M.D.  Johns Hopkins School of Medicine
• 1993-98 Ph.D. University of Pennsylvania

Board Certifications

• American Board of Radiology, Radiation Oncology, 1994

Areas of Interest

Dr. Kao also maintains a translational and basic research laboratory that studies prostate, breast, and brain tumor cell biology. Specific interests within basic/translational research of the Kao also includes a focus on mechanisms of cancer cell death, cell cycle checkpoints, DNA damage, and novel vertebrate model systems for cancer research. For the Kao Laboratory website, please go to http://www.xrt.upenn.edu/GaryKao.shtml

Recent Publications

Blank K, Cascardi M and Kao G. The utility of serial CBC in patients with prostate cancer. Int J Rad Oncol Biol Phys. 44(2): 317-21, 1999.

Kao G and Devine P. Use of complementary health practices by prostate carcinoma patients undergoing radiation therapy. Cancer 88(3): 615-9, 2000.

Kao G, McKenna WG and Yen TJ.  Detection of repair activity during the DNA Damage-induced G2 Delay.  Oncogene, (27): 3486-96, 2001.

Kao GD, McKenna MG, Guenther MG, Muschel RJ, Lazar MA, Yen TJ.  Histone deacetylase 4 interacts with 53BP1 to mediate the DNA damage response.  J Cell Biol. Mar 31;160(7):1017-27, 2003.

Daniel R, Kao G, Taganov K, Greger JG, Favorova O, Merkel G, Yen TJ, Katz RA, Skalka AM.  Evidence that the retroviral DNA integration process triggers an ATR-dependent DNA damage response.  Proc Natl Acad Sci U S A. Apr 15;100(8):4778-83, 2003.

Lee EA, Keutmann MK, Dowling M, Harris E, Chan E, Kao GD.  Inactivation of the mitotic checkpoint targets human cancer cells to killing by microtubule-disrupting drugs.  Molec Cancer Ther, 3(6):661-9, 2004.

Liu F, Dowling M, Yang XJ, Kao GD. Caspase-mediated specific cleavage of human histone deacetylase 4 (HDAC4).  J Biol Chem, 279(33):34537-46, 2004.

Dowling M, Voong KR, Kim MJ, Keutmann M, Harris E, Kao GD.  Mitotic spindle checkpoint inactivation by Trichostatin A defines a mechanism for increasing cancer cell killing by microtubule-disrupting agents .  Cancer Biol Ther, 4:2. e86-e95, EPUB ahead of print, 2005.

Kim M, Murphy K, Liu F, Parker S, Dowling ML, Baff W, Kao GD. Caspase-mediated specific cleavage of BubR1 is a determinant of the mitotic spindle checkpoint. Molecular and Cellular Biology, 25(21):9232-48, 2005.

Liu F, Pore N, Kim M, Voong KR, Dowling M, Maity A, Kao GD. Regulation of histone deacetylase 4 expression by the SP family of transcription factors. Molecular Biology of the Cell. Feb; 17(2):585-97, 2006.

Kim IA, Shin JH, Kim IH, Kim JH, Kim JS, Wu HG, Chie EK, Ha SW, Park CI, Kao GD. Histone deacetylase inhibitor-mediated radiosensitization of human cancer cells: class differences and the potential influence of p53. Clin Cancer Res. Feb 1; 12(3 Pt 1): 940-9, 2006.

Pore N, Jiang Z, Gupta A, Cerniglia G, Kao GD, Maity A. EGFR tyrosine kinase inhibitors decrease VEGF expression by both hypoxia-inducible factor (HIF)-1-independent and HIF-1-dependent mechanisms. Cancer Research. Mar 15; 66(6): 3197-204, 2006.

Farkash EA, Kao GD, Horman SR, Prak ET. Gamma radiation increases endonuclease-dependent L1 retrotransposition in a cultured cell assay. Nucleic Acids Res. Feb 28; 34(4):1196-204, 2006.

Geiger G, Parker S, Beothy A, Tucker J, Mullins MC, Kao GD. Zebrafish as a ‘‘Biosensor’’? Effects of ionizing radiation and amifostine on embryonic viability and development. Cancer Research, 66: (16), August 15, 2006.

Li Y, Kao GD, Garcia BA, Shabanowitz J, Hunt DF, Qin J, Phelan C, Lazar MA. A novel histone deacetylase pathway regulates mitosis by modulating Aurora B kinase activity. Genes and Development, 20 (18): 2566-2579, 2006.

Yu J, Palmer C, Alenghat T, Li Y, Kao GD, Lazar MA. The Corepressor SMRT facilitates cellular recovery from DNA double-strand breaks. Cancer Research, in press, 2006.

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