Perelman School of Medicine at the University of Pennsylvania
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The Department of Radiation Oncology is in the new Perelman Center. Occupying approximately 80,000 square feet on the Concourse Level, the new treatment facilities includes the most advanced proton and conventional radiation treatment modalities available as well as public spaces designed for the highest levels of patient comfort.


Dorsey Lab

Jay F. Dorsey, M.D., Ph.D.
Assistant Professor

Dorsey picture

University of Pennsylvania School of Medicine
Department of Radiation Oncology
Smilow Center for Translational Research
3400 Civic Center Blvd.
Philadelphia, PA 19104-5156
(215) 662-2428
JayD@uphs.upenn.edu
 
Publications
Dorsey CV
 

Research Interests

In a broad sense, my laboratory focuses on understanding the underlying mechanisms whereby cancers demonstrate resistance to radiation and chemotherapy and characterizing normal cell/tissue responses to radiation therapy. This information will give us a framework to develop ways to target oncogenic pathways that lead to therapeutic resistance and identify potential molecular interventions that may reduce the normal tissue complications of radiation therapy. One major focus concerns the elucidation of mechanisms whereby the tumor suppressor p53 regulates transcriptional repression and more specifically how these pathways influence response to radiation. Recently, we have identified two transcriptional co-repressors which appear to be p53-regulated targets. We hypothesize that the loss of this putative repression mechanism in the context of neoplastic conversion may contribute to tumor progression and/or therapeutic resistance. A second area of interest is the application of in vivo imaging methods to preclinical studies in relevant biological models of cancer with a focus on high-grade brain tumor biology. This includes evaluation of the efficacy of novel therapeutic combinations in preclinical animal models and determination of timing, dosage, and in vivo mechanisms of anti-tumor action.

Dorsey Lab

  • Jay F. Dorsey, M.D., Ph.D.
  • Mariana Cooke (Postdoctoral Fellow)
  • James J. Davis (Research Fellow)
  • Xiangsheng Xu, M.D. (Research Specialist)

Former Lab members

  • David Steinmetz (Penn undergratuate student)
  • Xiaobing Tian, Ph.D. (research specialist)
  • Wensheng Yang, Ph.D. (research specialist)
  • Emigdio Reyes, Ph.D. (Postdoctoral Fellow)
  • Melissa Stangl (Masters student)
  • Andrew Hollander, M.S., M.D., Resident, Department of Radiation Oncology, Hospital of the University of Pennsylvania
  • Brian Baumann, A.B., Medical Student, University of Pennsylvania
  • Joe Benci, Visiting Undergraduate Student, Cornell University

 



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