Jay F. Dorsey, M.D., Ph.D.
Assistant Professor
University of Pennsylvania School of Medicine
Department of Radiation Oncology
180 I John Morgan Building
3620 Hamilton Walk
Philadelphia, PA 19104
(215) 898 -1080
JayD@xrt.upenn.edu
Research Interests
In a broad sense, my laboratory focuses on understanding the underlying
mechanisms whereby cancers demonstrate resistance to radiation and
chemotherapy and characterizing normal cell/tissue responses to
radiation therapy. This information will give us a framework to develop
ways to target oncogenic pathways that lead to therapeutic resistance
and identify potential molecular interventions that may reduce the
normal tissue complications of radiation therapy. One major focus
concerns the elucidation of mechanisms whereby the tumor suppressor p53
regulates transcriptional repression and more specifically how these
pathways influence response to radiation. Recently, we have identified
two transcriptional co-repressors which appear to be p53-regulated
targets. We hypothesize that the loss of this putative repression
mechanism in the context of neoplastic conversion may contribute to
tumor progression and/or therapeutic resistance. A second area of
interest is the application of in vivo imaging methods to preclinical
studies in relevant biological models of cancer with a focus on
high-grade brain tumor biology. This includes evaluation of the efficacy
of novel therapeutic combinations in preclinical animal models and
determination of timing, dosage, and in vivo mechanisms of anti-tumor
action.
Dorsey Lab
- Jay F. Dorsey, M.D., Ph.D.
- Xiaobing Tian, Ph.D.
- Wensheng Yang, Ph.D.
- Andrew Hollander, B.S., Master of Science in Translational Research/Doctor of Medicine Candidate, University of Pennsylvania School of Medicine
- Andrew Zheng, Undergraduate Student, University of Pennsylvania
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