Cameron J. Koch , Ph.D.
Professor
Radiation Oncology, University of Pennsylvania,
195 (main office) 108A (lab) John Morgan Bldgm.,
37th St. and Hamilton Walk,
Philadelphia, PA 19104-6702
Phone: 215-898-0073
Fax: 215-898-0090
Areas of Interest and Expertise
Measurment of radioresistant hypoxic tumor cells in vivo using:
immunohistochemistry and/or flow cytometry
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non-invasive imaging
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Quantification of tissue pO2
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Control and measurement of oxygen concentration and thiols
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Quantitative Fluorescence Microscopy
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Oxidative damage (primarily sulfydryl to disulfide) of DNA repair systems
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Effects of oxygen and oxygen radicals in biological or biochemical systems
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Development of fluorine-based PET imaging methods
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Automated chemical synthesis
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Mechanisms of action of radiation sensitizing and radiation protecting agents (survival or DNA damage)
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Models for competitive reactions of radiation modifying agents
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Metabolism of thiols and nitroheterocyclics (including cytotoxicity)
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Measurement of intracellular drug concentrations
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