Amit Maity, M.D., Ph.D.
Associate Professor of Radiation Oncology

Education

• B.A. Boston University (Mathematics) summa cum laude, Boston, MA 1979-1985
• M.D. Boston University School of Medicine, cum laude, Boston, MA (Six-year combined B.A./M.D. program) 1981-1985
• Ph.D. Biomedical Graduate Studies, (Pathology) University of Pennsylvania, Philadelphia, PA 1992-1995
• Internship Department of Medicine, Mount Sinai Hospital, New York, NY 1985-1986
• Resident, Department of Radiation Oncology, Hosptial of the University of Pennsylvania, Philadelphia, PA 1988-1991
• Fellow, Department of Radiation Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA 1991-1992
• Postdoctoral Trainee, Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA 1992-1995
• Postdoctoral Researcher, Department of Medicine, John Hopkins University School of Medicine, Baltimore, MD 1995-1997

Board Certifications

• American Board of Internal Medicine (Internal Meddicine) 1988
• American Board of Radiology (Radiation Oncology) 1991

Areas of Interest

Research:

The primary research project in my laboratory is funded by an NIH R01 grant entitled "Regulation of VEGF by EGFR, PTEN and Ras". VEGF is an important regulator of blood vessel growth in cancer, and targeting it may be a means of inhibiting tumor growth. We have focused on a specific pathway that is often deregulated in human cancers, thePI3 kinase/Akt pathway. We have found that activation of this pathway leads to increased VEGF expression through two different mechanism, one that is hypoxia-inducible factor 1 (HIF-1) dependent and another that is mediated through the transcription factor Sp1. We are also investigating EGFR inhibitors such as Iressa and Tarceva, which downregulate VEGF and HIF-1 alpha expression. We are trying to understand the mechanism underlying this and the effects of this on tumor oxygenation, which could have important implications in the combined use of these drugs with radiation.

Clinical:

My clinical responsibility has recently changed from pediatric radiation oncology to coverage of the VA service two days a week where I will be supervising the lung service as well as some of the prostate and gastrointestinal tumors. As part of my clinical interest at the VA I am very interested in trying to introduce a protocol using a radioactive nitroimidazole compound (EF5) that will allow us to image hypoxia in tumors non-invasively. We will then be able to follow hypoxia in tumors in response to various biological agents such as EGF inhibitors as well as after radiation and correlate this with clinical outcome.

Publications

Maity, A, Pore, N, Lee, J, Solomon, D, O’Rourke, D. EGFR regulates VEGF

transcriptional activation in human glioblastoma cells by a hypoxia-independent pathway involving Ras and PI(3) kinase. Cancer Res. 60: 5879-5886, 2000.

Chen, C, Pore, N, Behrooz, A, Ismail-Beigi, F and Maity, A. Regulation of Glut1 by HIF1: Interaction between H-ras and hypoxia. J. Biol. Chem. 276: 9519, 2001.

Pore, N, Liu, S, Haas-Kogan, D A, O'Rourke, D M, Maity, A PTEN mutation and epidermal growth factor receptor activation regulate vascular endothelial growth factor (VEGF) mRNA expression in human glioblastoma cells by transactivating the proximal VEGF promoter. Cancer Res. 63: 236, 2003.

Chen, C, Shu, H-K G, Goldwein, JW, Womer, RB, Maity, A Volumetric considerations in radiotherapy for pediatric parameningeal rhabdomyosarcomas. Int J Radiat Oncol Biol Phys. 55:1294-9, 2003.

Maity, A, Shu, H-K G, Janss, A, Belasco, JB, Rorke, R, Phillips, PC, Sutton, LN, Goldwein, J.W. Craniospinal radiation in the treatment of biopsy-proven intracranial germinomas: twenty-five years experience in a single center Int. J. Radiat. Oncol. Biol Phys. 58:1165-1170, 2004.

Bucci, MK, Maity, A, Janss, AJ, Belasco, JB, Fisher, MJ, Tochner, ZA, Rorke, L, Sutton, LN, Phillips PC and Shu, H-KG: Near complete surgical resection predicts a favorable outcome in pediatric non-brainstem, malignant gliomas: results from a single center in the MRI era. Cancer 101: 817-824, 2004.

Maity, A, Shu, H-K, G, Tan, J E, Ruffer, J, Sutton, LN, Tochner, Z, Lustig, R Treatment of pediatric intracranial arteriovenous malformations with linear accelerator based-stereotactic radiosurgery: the University of Pennsylvania experience. Pediatric Neurosurgery 40: 207-14, 2004.

Pore, N, Liu, S, Shu, H-S, Li, B, Haas-Kogan, D, Stokoe, D, Milanini-Mongiat, J, Pages, G, O’Rourke,, DM, Bernhard, E, Maity, A Akt activation can upregulate VEGF expression independently of hypoxia inducible factor-1 via phosphorylation of Sp1 family members. Mol. Biol. Cell. 15: 4841, 2004.

Shi Y, Lee CS, Wu, J, Koch, CJ, Thom, SR, Maity, A, Bernhard, E. Effects of hyperbaric oxygen exposure on experimental head and neck tumor growth, oxygenation and vasculature, Head and Neck 27: 362, 2005.

Weiner DJ, Maity A, Carlson CA, Ginsberg JP. Pulmonary function abnormalitites in children treated with whole lung irradiation. Pediatric Blood and Cancer, 2005 May 30 (Epub ahead of print)

 

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